| 72 Investment Holdings, LLC | 474,067 | $2,266,040 | 15.18% |
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| Elmwood Wealth Management, Inc. | 2,364,415 | $11,301,904 | 5.45% |
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| PFM Health Sciences, LP | 6,724,715 | $32,144,138 | 1.51% |
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| SILVERARC CAPITAL MANAGEMENT, LLC | 892,786 | $4,267,517 | 1.29% |
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| Avidity Partners Management LP | 6,050,212 | $28,920,013 | 1.16% |
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| Paradigm Biocapital Advisors LP | 2,944,513 | $14,074,772 | 0.96% |
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| Kynam Capital Management, LP | 1,068,527 | $5,107,559 | 0.84% |
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| Green Alpha Advisors, LLC | 110,524 | $528,305 | 0.41% |
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| DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) | 3,500,000 | $16,730,000 | 0.37% |
|---|
| Bruce & Co., Inc. | 200,000 | $956,000 | 0.33% |
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| SVB FINANCIAL GROUP | 20,714 | $99,013 | 0.19% |
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| Atom Investors LP | 123,427 | $589,981 | 0.14% |
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| Nelson Capital Management, LLC | 85,020 | $406,396 | 0.10% |
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| Rokos Capital Management LLP | 2,748,139 | $13,287,252 | 0.10% |
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| MAVERICK CAPITAL LTD | 652,542 | $3,119,151 | 0.07% |
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| STANSBERRY ASSET MANAGEMENT, LLC | 77,232 | $369,169 | 0.06% |
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| Virtus ETF Advisers LLC | 21,358 | $102,091 | 0.06% |
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| Aristides Capital LLC | 25,555 | $122,153 | 0.05% |
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| Point72 Asset Management, L.P. | 3,499,833 | $16,729,202 | 0.05% |
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| Assenagon Asset Management S.A. | 2,648,582 | $12,660,222 | 0.04% |
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