| Novo Holdings A/S | 3,463,577 | $153,402 | 6.51% |
|---|
| HealthCor Management, L.P. | 1,850,450 | $81,956 | 5.47% |
|---|
| VONTOBEL ASSET MANAGEMENT INC | 13,013,297 | $603,780 | 4.00% |
|---|
| SECTOR GAMMA AS | 395,335 | $17,509 | 3.80% |
|---|
| FARALLON CAPITAL MANAGEMENT LLC | 15,740,257 | $697,136 | 3.70% |
|---|
| Crystal Rock Capital Management | 102,575 | $4,543 | 3.01% |
|---|
| DSM CAPITAL PARTNERS LLC | 5,029,139 | $222,740 | 2.98% |
|---|
| VIKING GLOBAL INVESTORS LP | 12,839,142 | $568,646 | 2.30% |
|---|
| INVERNESS COUNSEL LLC /NY/ | 1,046,717 | $46,359 | 2.08% |
|---|
| OMERS ADMINISTRATION Corp | 3,487,160 | $154,446 | 1.98% |
|---|
| HOMESTEAD ADVISERS CORP | 1,821,526 | $80,675 | 1.98% |
|---|
| SIRIOS CAPITAL MANAGEMENT L P | 326,593 | $14,465 | 1.92% |
|---|
| TANDEM CAPITAL MANAGEMENT CORP /ADV | 62,254 | $2,733 | 1.89% |
|---|
| PREMIER ASSET MANAGEMENT LLC | 135,715 | $6,011 | 1.87% |
|---|
| Nexus Investment Management ULC | 400,534 | $17,740 | 1.86% |
|---|
| Steadfast Capital Management (UK) Ltd. | 28,008 | $1,240 | 1.74% |
|---|
| Ellsworth Advisors, LLC | 92,425 | $4,353 | 1.54% |
|---|
| ANCHOR CAPITAL ADVISORS LLC | 1,571,490 | $69,601 | 1.47% |
|---|
| NBW CAPITAL LLC | 137,105 | $6,072 | 1.44% |
|---|
| ZWJ INVESTMENT COUNSEL INC | 602,995 | $26,707 | 1.41% |
|---|