| Foresight Global Investors, Inc. | 267,730 | $18,130,676 | 10.09% |
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| Endurant Capital Management LP | 96,444 | $6,531,188 | 5.87% |
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| Sofinnova Investments, Inc. | 1,362,836 | $92,291,254 | 5.82% |
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| Artia Global Partners LP | 190,752 | $12,917,725 | 5.37% |
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| OAK FAMILY ADVISORS, LLC | 134,767 | $9,126,421 | 4.31% |
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| SPHERA FUNDS MANAGEMENT LTD. | 285,060 | $19,304,263 | 3.52% |
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| Harvest Portfolios Group Inc. | 794,033 | $53,771,915 | 2.54% |
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| PRIMECAP MANAGEMENT CO/CA/ | 43,889,365 | $2,972,187,798 | 2.51% |
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| ZWJ INVESTMENT COUNSEL INC | 618,011 | $41,851,730 | 2.32% |
|---|
| CRAWFORD INVESTMENT COUNSEL INC | 1,523,730 | $103,187,003 | 2.24% |
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| GQG Partners LLC | 14,045,872 | $951,186,452 | 2.20% |
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| Buckingham Capital Management, Inc. | 199,607 | $13,517,386 | 2.06% |
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| FARALLON CAPITAL MANAGEMENT LLC | 6,059,553 | $410,352,929 | 2.06% |
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| Altrius Capital Management Inc | 98,084 | $6,642,258 | 1.97% |
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| Timber Creek Capital Management LLC | 79,682 | $5,396,104 | 1.95% |
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| CIDEL ASSET MANAGEMENT INC | 553,617 | $37,490,940 | 1.87% |
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| AIMZ Investment Advisors, LLC | 61,115 | $4,138,741 | 1.84% |
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| Hilton Capital Management, LLC | 203,174 | $13,758,973 | 1.83% |
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| SAL Trading, LLC | 18,800 | $1,273,136 | 1.78% |
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| ZEVIN ASSET MANAGEMENT LLC | 126,549 | $8,570 | 1.72% |
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