| Darwin Global Management, Ltd. | 1,661,684 | $110,236 | 100.00% |
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| SPHERA FUNDS MANAGEMENT LTD. | 836,817 | $55,514 | 7.85% |
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| Eagle Health Investments LP | 445,665 | $29,565 | 7.28% |
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| Avidity Partners Management LP | 3,700,000 | $245,458 | 5.11% |
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| OAK FAMILY ADVISORS, LLC | 127,524 | $8,460 | 3.31% |
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| Senator Investment Group LP | 1,500,000 | $99,510 | 3.08% |
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| Iron Triangle Partners LP | 380,000 | $25,209 | 3.00% |
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| Heirloom Wealth Management | 59,460 | $3,754 | 2.61% |
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| Ruffer LLP | 1,604,629 | $106,443 | 2.49% |
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| ZWJ INVESTMENT COUNSEL INC | 663,355 | $44,007 | 2.33% |
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| PRIMECAP MANAGEMENT CO/CA/ | 46,317,880 | $3,072,728 | 2.32% |
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| Tekla Capital Management LLC | 990,675 | $65,721 | 2.31% |
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| CRAWFORD INVESTMENT COUNSEL INC | 1,742,060 | $115,568 | 2.24% |
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| Vigilant Capital Management, LLC | 440,903 | $29,250 | 2.23% |
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| Hardman Johnston Global Advisors LLC | 1,041,889 | $69,119 | 2.22% |
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| SCHARF INVESTMENTS, LLC | 1,124,916 | $74,641 | 2.21% |
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| Private Harbour Investment Management & Counsel, LLC | 38,743 | $2,570 | 2.15% |
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| Timber Creek Capital Management LLC | 101,975 | $6,765 | 2.05% |
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| ARDSLEY ADVISORY PARTNERS LP | 181,000 | $12,008 | 2.00% |
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| SECTOR GAMMA AS | 124,000 | $8,226 | 1.79% |
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