| Alerce Investment Management, L.P. | 7,056,024 | $16,652,217 | 28.46% |
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| Logos Global Management LP | 5,300,000 | $12,508,000 | 1.67% |
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| Bain Capital Life Sciences Investors, LLC | 5,701,926 | $13,456,545 | 1.50% |
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| Velan Capital Investment Management LP | 459,746 | $1,085,001 | 0.88% |
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| Octagon Capital Advisors LP | 2,050,000 | $4,838,000 | 0.74% |
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| SECTORAL ASSET MANAGEMENT INC | 898,785 | $2,121,133 | 0.41% |
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| Redmile Group, LLC | 3,503,190 | $8,267,528 | 0.39% |
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| SILVERARC CAPITAL MANAGEMENT, LLC | 399,716 | $943,330 | 0.29% |
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| GMT CAPITAL CORP | 2,810,471 | $6,632,712 | 0.25% |
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| Simplify Asset Management Inc. | 492,595 | $1,162,524 | 0.13% |
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| Soleus Capital Management, L.P. | 515,400 | $1,216,344 | 0.11% |
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| Board of Trustees of The Leland Stanford Junior University | 494,169 | $1,166,239 | 0.09% |
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| KENNEDY CAPITAL MANAGEMENT LLC | 976,987 | $2,305,689 | 0.06% |
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| Forefront Analytics, LLC | 31,680 | $74,766 | 0.04% |
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| Woodline Partners LP | 1,464,365 | $3,455,901 | 0.04% |
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| UBS OCONNOR LLC | 549,246 | $1,296,221 | 0.03% |
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| DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) | 583,913 | $1,378,035 | 0.03% |
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| CORNERCAP INVESTMENT COUNSEL INC | 46,698 | $110,207 | 0.02% |
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| Allegheny Financial Group LTD | 21,700 | $51,212 | 0.02% |
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| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,349,975 | $5,545,941 | 0.01% |
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