| BML Capital Management, LLC | 12,988,134 | $14,286,947 | 10.20% |
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| Stonepine Capital Management, LLC | 1,927,446 | $2,120,191 | 1.95% |
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| Aldebaran Capital, LLC | 858,152 | $943,967 | 0.88% |
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| Acuitas Investments, LLC | 464,120 | $510,532 | 0.27% |
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| Trium Capital LLP | 1,892,050 | $2,081 | 0.26% |
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| Aisling Capital Management LP | 434,455 | $477,901 | 0.21% |
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| Samsara BioCapital, LLC | 696,171 | $765,788 | 0.16% |
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| Deuterium Capital Management, LLC | 72,091 | $79,300 | 0.13% |
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| Bain Capital Life Sciences Investors, LLC | 1,000,000 | $1,100,000 | 0.12% |
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| Rock Springs Capital Management LP | 2,753,495 | $3,028,845 | 0.09% |
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| Palo Alto Investors LP | 569,832 | $626,815 | 0.07% |
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| Alpine Global Management, LLC | 177,909 | $195,700 | 0.03% |
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| GSA CAPITAL PARTNERS LLP | 336,677 | $370 | 0.03% |
|---|
| Point72 Asia (Singapore) Pte. Ltd. | 107,929 | $118,722 | 0.02% |
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| Marquette Asset Management, LLC | 83,979 | $92,377 | 0.02% |
|---|
| Frazier Life Sciences Management, L.P. | 264,377 | $290,815 | 0.01% |
|---|
| Y-Intercept (Hong Kong) Ltd | 114,806 | $126,287 | 0.01% |
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| ACADIAN ASSET MANAGEMENT LLC | 1,913,449 | $2,103 | 0.01% |
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| BBR PARTNERS, LLC | 60,000 | $66,000 | 0.01% |
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| TWO SIGMA ADVISERS, LP | 1,436,900 | $1,580,590 | 0.00% |
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