| Stonepine Capital Management, LLC | 9,104,275 | $32,593,305 | 10.83% |
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| Altium Capital Management LP | 2,723,011 | $9,748,379 | 5.08% |
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| Velan Capital Investment Management LP | 1,736,100 | $6,215,238 | 5.01% |
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| AWM Investment Company, Inc. | 5,999,872 | $21,479,542 | 3.17% |
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| Mesirow Financial Investment Management, Inc. | 72,677 | $260,184 | 1.13% |
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| Caligan Partners LP | 597,513 | $2,139,097 | 0.98% |
|---|
| Perceptive Advisors | 6,984,319 | $25,003,862 | 0.83% |
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| OBERWEIS ASSET MANAGEMENT INC/ | 2,078,400 | $7,440,672 | 0.79% |
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| TANG CAPITAL MANAGEMENT LLC | 1,360,000 | $4,868,800 | 0.69% |
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| EAM Investors, LLC | 967,146 | $3,462,383 | 0.67% |
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| EAM Global Investors LLC | 632,352 | $2,263,820 | 0.61% |
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| Magnetar Financial LLC | 5,874,178 | $21,029,557 | 0.54% |
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| Virtus Fund Advisers, LLC | 12,228 | $43,776 | 0.31% |
|---|
| Virtus Investment Advisers, Inc. | 72,895 | $260,964 | 0.18% |
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| Virtus ETF Advisers LLC | 78,224 | $280,042 | 0.17% |
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| DRIEHAUS CAPITAL MANAGEMENT LLC | 3,499,616 | $12,528,625 | 0.16% |
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| GLOBEFLEX CAPITAL L P | 233,651 | $836,471 | 0.10% |
|---|
| BOOTHBAY FUND MANAGEMENT, LLC | 1,045,212 | $3,741,859 | 0.09% |
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| GSA CAPITAL PARTNERS LLP | 242,284 | $867 | 0.07% |
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| KENNEDY CAPITAL MANAGEMENT LLC | 791,047 | $2,831,948 | 0.07% |
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