| Opaleye Management Inc. | 1,890,000 | $15,800,400 | 5.14% |
|---|
| Ghost Tree Capital, LLC | 1,000,000 | $8,360,000 | 2.75% |
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| Soleus Capital Management, L.P. | 2,884,382 | $24,113,434 | 2.22% |
|---|
| M28 Capital Management LP | 216,600 | $1,810,776 | 2.08% |
|---|
| Paradigm Biocapital Advisors LP | 3,619,015 | $30,254,965 | 2.05% |
|---|
| 683 Capital Management, LLC | 1,350,000 | $11,286,000 | 0.88% |
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| Parkwood LLC | 165,414 | $6,081 | 0.66% |
|---|
| Spotlight Asset Group, Inc. | 79,000 | $660,440 | 0.60% |
|---|
| Pier Capital, LLC | 392,709 | $3,283,047 | 0.53% |
|---|
| Quantum Private Wealth, LLC | 91,081 | $761,438 | 0.36% |
|---|
| Parkman Healthcare Partners LLC | 209,319 | $1,749,907 | 0.32% |
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| Blueshift Asset Management, LLC | 61,075 | $510,587 | 0.30% |
|---|
| AVAII WEALTH MANAGEMENT, LLC | 34,022 | $284,420 | 0.22% |
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| Capital CS Group, LLC | 17,525 | $146,509 | 0.17% |
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| Nebula Research & Development LLC | 39,146 | $327,261 | 0.17% |
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| CLARK FINANCIAL SERVICES GROUP INC /BD | 14,195 | $118,670 | 0.16% |
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| Jump Financial, LLC | 472,972 | $3,954,045 | 0.15% |
|---|
| AIGEN INVESTMENT MANAGEMENT, LP | 94,748 | $792,093 | 0.15% |
|---|
| Rhenman & Partners Asset Management AB | 160,000 | $1,337,600 | 0.14% |
|---|
| INNOVIS ASSET MANAGEMENT LLC | 37,049 | $309,730 | 0.12% |
|---|