| Q Global Advisors, LLC | 320,000 | $23,366 | 15.02% |
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| DAFNA Capital Management LLC | 565,000 | $41,256,300 | 12.83% |
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| CHIRON CAPITAL MANAGEMENT, LLC | 148,706 | $10,858,512 | 9.34% |
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| Investure, LLC | 561,600 | $41,008,032 | 8.75% |
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| Soleus Capital Management, L.P. | 1,250,000 | $91,275,000 | 8.42% |
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| Ghost Tree Capital, LLC | 300,000 | $21,906,000 | 7.20% |
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| SILVERARC CAPITAL MANAGEMENT, LLC | 300,000 | $21,906,000 | 6.64% |
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| Main Management Fund Advisors LLC | 281,000 | $20,519 | 5.97% |
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| Nantahala Capital Management | 950,000 | $69,369,000 | 5.93% |
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| Yelin Lapidot Holdings Management Ltd. | 105,972 | $7,738,075 | 4.60% |
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| Ikarian Capital, LLC | 5,000 | $36,510,000 | 4.39% |
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| Sivik Global Healthcare LLC | 100,000 | $7,302 | 3.69% |
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| Phoenix Holdings Ltd. | 2,151,359 | $157,092,234 | 2.88% |
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| McGuire Investment Group, LLC | 192,030 | $14,022,060 | 2.70% |
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| Financial Advantage, Inc. | 22,737 | $1,660,256 | 2.55% |
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| United Capital Management of KS, Inc. | 102,217 | $7,463,907 | 2.54% |
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| MBB PUBLIC MARKETS I LLC | 514,411 | $37,562,286 | 2.27% |
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| Vanderbilt University | 118,968 | $8,687,043 | 2.24% |
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| Ameraudi Asset Management, Inc. | 63,570 | $4,641,882 | 2.21% |
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| Migdal Insurance & Financial Holdings Ltd. | 1,409,200 | $102,900 | 2.20% |
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