| Redmile Group, LLC | 2,003,367 | $232,390,572 | 11.06% |
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| Frazier Life Sciences Management, L.P. | 988,460 | $114,661,360 | 7.62% |
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| S Squared Technology, LLC | 108,215 | $12,552,940 | 6.77% |
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| Avoro Capital Advisors LLC | 2,565,555 | $297,604,380 | 4.64% |
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| APIS CAPITAL ADVISORS, LLC | 24,000 | $2,784,000 | 3.61% |
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| Nicholas Investment Partners, LP | 355,611 | $41,250,876 | 3.08% |
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| Ghost Tree Capital, LLC | 80,000 | $9,280,000 | 3.05% |
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| SILVERARC CAPITAL MANAGEMENT, LLC | 71,531 | $8,297,596 | 2.52% |
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| Affinity Asset Advisors, LLC | 57,500 | $6,670,000 | 1.88% |
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| INTERNATIONAL BIOTECHNOLOGY TRUST PLC | 46,092 | $5,344,828 | 1.80% |
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| Hood River Capital Management LLC | 460,489 | $53,416,724 | 1.72% |
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| Soleus Capital Management, L.P. | 117,892 | $13,675,472 | 1.26% |
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| Ikarian Capital, LLC | 845 | $9,802,000 | 1.18% |
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| Integral Health Asset Management, LLC | 70,000 | $8,120,000 | 1.12% |
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| Capital Impact Advisors, LLC | 5,726 | $664,216 | 1.11% |
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| Eversept Partners, LP | 108,771 | $12,617,436 | 1.07% |
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| EAM Global Investors LLC | 29,517 | $3,423,972 | 0.93% |
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| JACOB ASSET MANAGEMENT OF NEW YORK LLC | 4,247 | $492,652 | 0.70% |
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| EFG Asset Management (North America) Corp. | 16,234 | $1,883,875 | 0.45% |
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| Woodline Partners LP | 321,944 | $37,345,504 | 0.44% |
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