| New Leaf Venture Partners, L.L.C. | 1,289,521 | $25,390,668 | 32.60% |
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| Aquilo Capital Management, LLC | 489,153 | $9,606,965 | 8.71% |
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| Finepoint Capital LP | 504,700 | $9,912,308 | 4.94% |
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| EcoR1 Capital, LLC | 5,467,063 | $107,373,117 | 3.62% |
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| Avidity Partners Management LP | 2,614,960 | $51,357,814 | 2.07% |
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| 5AM Venture Management, LLC | 320,000 | $6,284,800 | 1.81% |
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| Nextech Invest Ltd. | 287,251 | $5,641,610 | 1.71% |
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| Capital Impact Advisors, LLC | 30,531 | $599,629 | 1.00% |
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| Bellevue Group AG | 2,125,200 | $41,738,928 | 0.67% |
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| Yelin Lapidot Holdings Management Ltd. | 49,503 | $972,239 | 0.58% |
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| ArrowMark Colorado Holdings LLC | 2,087,292 | $40,994,415 | 0.50% |
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| Parkman Healthcare Partners LLC | 104,117 | $2,044,858 | 0.38% |
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| Frazier Life Sciences Management, L.P. | 285,331 | $5,603,901 | 0.37% |
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| Birchview Capital, LP | 15,000 | $294,600 | 0.25% |
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| TANG CAPITAL MANAGEMENT LLC | 80,000 | $1,571,200 | 0.22% |
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| Corton Capital Inc. | 21,750 | $427,170 | 0.22% |
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| Alpha DNA Investment Management LLC | 26,759 | $525,547 | 0.22% |
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| Mach-1 Financial Group, LLC | 23,577 | $463,052 | 0.19% |
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| Rhenman & Partners Asset Management AB | 85,000 | $1,669,400 | 0.18% |
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| PDT Partners, LLC | 65,116 | $1,278,878 | 0.16% |
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