| Invus Financial Advisors, LLC | 1,612,077 | $28,936,782 | 18.14% |
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| Octagon Capital Advisors LP | 1,968,000 | $35,325,600 | 5.43% |
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| Decheng Capital Management III (Cayman), LLC | 869,790 | $15,612,731 | 5.21% |
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| Boxer Capital, LLC | 1,602,200 | $28,759,490 | 1.53% |
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| SECTORAL ASSET MANAGEMENT INC | 375,456 | $6,739,435 | 1.31% |
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| DAFNA Capital Management LLC | 222,717 | $3,997,770 | 1.24% |
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| PFM Health Sciences, LP | 1,405,056 | $25,220,755 | 1.19% |
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| Ikarian Capital, LLC | 4,000 | $7,180,000 | 0.86% |
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| Capital Impact Advisors, LLC | 24,280 | $435,826 | 0.73% |
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| Parkman Healthcare Partners LLC | 205,109 | $3,681,707 | 0.68% |
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| SUVRETTA CAPITAL MANAGEMENT, LLC | 597,099 | $10,717,927 | 0.58% |
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| Ikarian Capital, LLC | 254,876 | $4,575,025 | 0.55% |
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| Ghost Tree Capital, LLC | 75,000 | $1,346,250 | 0.44% |
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| Woodline Partners LP | 1,037,282 | $18,619,212 | 0.22% |
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| Alpha DNA Investment Management LLC | 25,716 | $461,603 | 0.19% |
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| Mach-1 Financial Group, LLC | 22,774 | $408,793 | 0.17% |
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| PLATINUM INVESTMENT MANAGEMENT LTD | 204,398 | $3,668,944 | 0.14% |
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| Granahan Investment Management | 195,599 | $3,511,002 | 0.12% |
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| FOX RUN MANAGEMENT, L.L.C. | 19,826 | $355,877 | 0.10% |
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| Eventide Asset Management | 240,000 | $4,308,000 | 0.08% |
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