| Sarissa Capital Management LP | 7,042,200 | $197,252,022 | 26.57% |
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| Krensavage Asset Management, LLC | 906,060 | $25,379 | 9.34% |
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| Hardman Johnston Global Advisors LLC | 5,608,064 | $157,081,873 | 5.27% |
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| GREAT POINT PARTNERS LLC | 875,044 | $24,509,982 | 4.46% |
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| Deep Track Capital, LP | 3,800,000 | $106,438,000 | 4.11% |
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| ACUTA CAPITAL PARTNERS, LLC | 126,500 | $3,543,265 | 2.38% |
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| Cannon Global Investment Management, LLC | 11,500 | $322,115 | 2.25% |
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| Price Jennifer C. | 124,089 | $3,475,733 | 2.01% |
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| Hudson Portfolio Management LLC | 53,295 | $1,492,793 | 1.70% |
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| Redwood Investments, LLC | 435,588 | $12,200,820 | 1.65% |
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| Palo Alto Investors LP | 603,400 | $16,901,234 | 1.60% |
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| Affinity Asset Advisors, LLC | 200,000 | $5,602,000 | 1.58% |
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| PFM Health Sciences, LP | 1,162,030 | $32,548,460 | 1.53% |
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| SECTORAL ASSET MANAGEMENT INC | 244,260 | $6,841,723 | 1.33% |
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| Birchview Capital, LP | 50,000 | $1,400,500 | 1.19% |
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| Rhenman & Partners Asset Management AB | 370,000 | $10,363,700 | 1.12% |
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| Integral Health Asset Management, LLC | 275,000 | $7,702,750 | 1.07% |
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| Sofinnova Investments, Inc. | 537,464 | $15,054,367 | 0.95% |
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| ARMISTICE CAPITAL, LLC | 1,896,775 | $53,128,668 | 0.81% |
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| Affinity Asset Advisors, LLC | 100,000 | $2,801,000 | 0.79% |
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