$3.75 Billion is the total value of RA Capital Management's 88 reported holdings in Q2 2022. The portfolio turnover from Q1 2022 to Q2 2022 was 37.5% .
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| ASND | ASCENDIS PHARMA A/Ssponsored adr | $703,512,000 | -20.8% | 7,567,900 | 0.0% | 18.76% | -3.2% | |
| BIIB | BIOGEN INC | $148,269,000 | -3.2% | 727,024 | 0.0% | 3.95% | +18.3% | |
| CYTEK BIOSCIENCES INC | $143,578,000 | -0.5% | 13,381,054 | 0.0% | 3.83% | +21.6% | ||
| AVTE | AEROVATE THERAPEUTICS INC | $129,166,000 | -14.7% | 8,263,982 | 0.0% | 3.44% | +4.2% | |
| DAWN | Buy | DAY ONE BIOPHARMACEUTICALS I | $126,027,000 | +109.6% | 7,040,622 | +16.2% | 3.36% | +156.1% |
| TVTX | TRAVERE THERAPEUTICS INC | $119,283,000 | -6.0% | 4,922,941 | 0.0% | 3.18% | +14.9% | |
| JANX | JANUX THERAPEUTICS INC | $105,869,000 | -14.9% | 8,670,644 | 0.0% | 2.82% | +4.1% | |
| PCVX | VAXCYTE INC | $99,687,000 | -9.9% | 4,581,203 | 0.0% | 2.66% | +10.1% | |
| IMGN | IMMUNOGEN INC | $97,837,000 | -5.5% | 21,741,458 | 0.0% | 2.61% | +15.5% | |
| NKTX | Buy | NKARTA INC | $96,159,000 | +50.8% | 7,805,129 | +39.2% | 2.56% | +84.2% |
| BLU | BELLUS HEALTH INC NEW | $94,528,000 | +34.3% | 10,230,274 | 0.0% | 2.52% | +64.1% | |
| ITOS | ITEOS THERAPEUTICS INC | $90,996,000 | -36.0% | 4,417,259 | 0.0% | 2.43% | -21.8% | |
| VERU | New | VERU INC | $89,270,000 | – | 7,900,000 | +100.0% | 2.38% | – |
| DICE THERAPEUTICS INC | $80,842,000 | -18.9% | 5,208,911 | 0.0% | 2.16% | -0.9% | ||
| New | PEPGEN INC | $80,750,000 | – | 8,131,952 | +100.0% | 2.15% | – | |
| FMTX | FORMA THERAPEUTICS HLDGS INC | $62,090,000 | -25.9% | 9,011,651 | 0.0% | 1.66% | -9.5% | |
| ACRS | Buy | ACLARIS THERAPEUTICS INC | $61,403,000 | +95.9% | 4,398,453 | +142.0% | 1.64% | +139.3% |
| PNT | POINT BIOPHARMA GLOBAL INC | $61,311,000 | -14.6% | 9,003,018 | 0.0% | 1.64% | +4.4% | |
| CLDX | CELLDEX THERAPEUTICS INC NEW | $55,942,000 | -20.8% | 2,075,000 | 0.0% | 1.49% | -3.2% | |
| WVE | Buy | WAVE LIFE SCIENCES LTD | $55,907,000 | +259.5% | 17,202,009 | +121.2% | 1.49% | +339.8% |
| VOR | VOR BIOPHARMA INC | $55,271,000 | -17.7% | 11,120,973 | 0.0% | 1.47% | +0.5% | |
| KNTE | KINNATE BIOPHARMA INC | $53,771,000 | +12.0% | 4,264,144 | 0.0% | 1.43% | +36.8% | |
| TYRA BIOSCIENCES INC | $51,741,000 | -33.2% | 7,236,454 | 0.0% | 1.38% | -18.3% | ||
| GHRS | Buy | GH RESEARCH PLCordinary shares | $48,886,000 | -44.6% | 4,898,373 | +1.5% | 1.30% | -32.3% |
| GERN | GERON CORP | $46,696,000 | +14.0% | 30,126,299 | 0.0% | 1.24% | +39.3% | |
| NTRA | NATERA INC | $46,437,000 | -12.9% | 1,310,289 | 0.0% | 1.24% | +6.4% | |
| ABOS | ACUMEN PHARMACEUTICALS INC | $45,923,000 | +20.2% | 9,770,773 | 0.0% | 1.22% | +46.8% | |
| NSTG | New | NANOSTRING TECHNOLOGIES | $45,523,000 | – | 3,584,478 | +100.0% | 1.21% | – |
| RXSIGHT INC | $42,983,000 | +13.7% | 3,052,796 | 0.0% | 1.15% | +38.9% | ||
| ENTA | Sell | ENANTA PHARMACEUTICALS INC | $42,389,000 | -38.2% | 896,724 | -7.0% | 1.13% | -24.6% |
| ELIEM THERAPEUTICS INC | $39,716,000 | -64.0% | 13,150,849 | 0.0% | 1.06% | -56.0% | ||
| RLMD | RELMADA THERAPEUTICS INC | $37,980,000 | -29.6% | 2,000,000 | 0.0% | 1.01% | -14.0% | |
| TIL | Buy | INSTIL BIO INC | $35,439,000 | -32.3% | 7,670,793 | +57.5% | 0.94% | -17.3% |
| ICOSAVAX INC | $34,172,000 | -18.6% | 5,963,565 | 0.0% | 0.91% | -0.5% | ||
| RNA | AVIDITY BIOSCIENCES INC | $31,492,000 | -21.3% | 2,167,391 | 0.0% | 0.84% | -3.8% | |
| DSGN | DESIGN THERAPEUTICS INC | $30,613,000 | -13.3% | 2,186,636 | 0.0% | 0.82% | +5.8% | |
| Buy | AN2 THERAPEUTICS INC | $29,050,000 | -47.4% | 3,748,389 | +2.2% | 0.78% | -35.7% | |
| RCKT | ROCKET PHARMACEUTICALS INC | $28,994,000 | -13.2% | 2,107,149 | 0.0% | 0.77% | +6.0% | |
| EYPT | EYEPOINT PHARMACEUTICALS INC | $26,526,000 | -35.2% | 3,370,506 | 0.0% | 0.71% | -20.9% | |
| ETNB | Buy | 89BIO INC | $25,060,000 | +33.9% | 7,782,669 | +56.7% | 0.67% | +63.7% |
| STSA | SATSUMA PHARMACEUTICALS INC | $24,485,000 | +8.9% | 5,914,252 | 0.0% | 0.65% | +33.3% | |
| PMVP | PMV PHARMACEUTICALS INC | $24,371,000 | -31.6% | 1,710,265 | 0.0% | 0.65% | -16.3% | |
| VERA | Sell | VERA THERAPEUTICS INCcl a | $21,488,000 | -53.5% | 1,578,820 | -19.7% | 0.57% | -43.2% |
| VRNA | VERONA PHARMA PLCsponsored ads | $21,369,000 | -16.0% | 5,100,000 | 0.0% | 0.57% | +2.7% | |
| RYTM | RHYTHM PHARMACEUTICALS INC | $20,215,000 | -64.0% | 4,871,067 | 0.0% | 0.54% | -56.0% | |
| TENAYA THERAPEUTICS INC | $19,995,000 | -52.2% | 3,551,508 | 0.0% | 0.53% | -41.6% | ||
| DYN | DYNE THERAPEUTICS INC | $19,271,000 | -28.7% | 2,805,045 | 0.0% | 0.51% | -12.9% | |
| New | HILLEVAX INC | $19,237,000 | – | 1,760,019 | +100.0% | 0.51% | – | |
| GH | GUARDANT HEALTH INC | $19,217,000 | -39.1% | 476,380 | 0.0% | 0.51% | -25.7% | |
| PARDES BIOSCIENCES INC | $18,957,000 | -57.5% | 6,175,038 | 0.0% | 0.50% | -48.1% | ||
| HOWL | WEREWOLF THERAPEUTICS INC | $17,554,000 | -7.0% | 4,291,881 | 0.0% | 0.47% | +13.6% | |
| DA32 LIFE SCNCE | $14,535,000 | -0.3% | 1,500,000 | 0.0% | 0.39% | +22.0% | ||
| CNCE | Buy | CONCERT PHARMACEUTICALS INC | $13,923,000 | +36.2% | 3,307,203 | +9.0% | 0.37% | +66.4% |
| MIST | MILESTONE PHARMACEUTICALS IN | $13,816,000 | -4.2% | 2,246,503 | 0.0% | 0.37% | +16.8% | |
| ACHL | ACHILLES THERAPEUTICS PLCsponsored ads | $12,637,000 | -14.3% | 5,014,687 | 0.0% | 0.34% | +4.7% | |
| BLSA | BCLS ACQUISITION CORP | $12,375,000 | +0.3% | 1,250,000 | 0.0% | 0.33% | +22.7% | |
| OTIC | OTONOMY INC | $11,648,000 | -13.3% | 5,600,000 | 0.0% | 0.31% | +6.1% | |
| Sell | LIANBIOsponsored ads | $9,985,000 | -64.8% | 4,622,574 | -39.6% | 0.27% | -57.1% | |
| FLACU | FRAZIER LIFESCIENCES ACQU CO | $9,870,000 | -1.2% | 1,000,000 | 0.0% | 0.26% | +20.6% | |
| ARYA SCIENCES ACQUISITN | $9,720,000 | +0.1% | 1,000,000 | 0.0% | 0.26% | +22.2% | ||
| RLAY | RELAY THERAPEUTICS INC | $9,197,000 | -44.0% | 549,055 | 0.0% | 0.24% | -31.8% | |
| IO BIOTECH INC | $8,676,000 | -11.9% | 1,857,755 | 0.0% | 0.23% | +7.4% | ||
| SLDB | SOLID BIOSCIENCES INC | $7,614,000 | -48.7% | 12,367,873 | 0.0% | 0.20% | -37.3% | |
| FVAM | 5 01 ACQUISITION CORP | $7,425,000 | +0.5% | 750,000 | 0.0% | 0.20% | +23.0% | |
| SYBX | Sell | SYNLOGIC INC | $6,700,000 | -58.1% | 5,825,858 | -12.6% | 0.18% | -48.7% |
| BDTX | BLACK DIAMOND THERAPEUTICS I | $6,371,000 | -11.2% | 2,589,904 | 0.0% | 0.17% | +8.3% | |
| IPSC | Sell | CENTURY THERAPEUTICS INC | $6,357,000 | -44.8% | 756,821 | -17.2% | 0.17% | -32.7% |
| HSAQ | HEALTH SCIENCES ACQ CORP 2 | $6,225,000 | +0.5% | 625,000 | 0.0% | 0.17% | +23.0% | |
| CNTB | CONNECT BIOPHARMA HLDGS LTDads | $6,082,000 | -71.2% | 6,991,003 | 0.0% | 0.16% | -64.9% | |
| BMEA | BIOMEA FUSION INC | $5,990,000 | +168.6% | 500,000 | 0.0% | 0.16% | +226.5% | |
| ATHA | New | ATHIRA PHARMA INC | $5,728,000 | – | 1,878,000 | +100.0% | 0.15% | – |
| Sell | XILIO THERAPEUTICS INC | $4,817,000 | -66.0% | 1,649,711 | -17.6% | 0.13% | -58.6% | |
| New | AADI BIOSCIENCE INC | $4,719,000 | – | 383,028 | +100.0% | 0.13% | – | |
| FLDM | New | STANDARD BIOTOOLS INC | $3,180,000 | – | 1,987,589 | +100.0% | 0.08% | – |
| TERN | New | TERNS PHARMACEUTICALS INC | $3,128,000 | – | 1,261,435 | +100.0% | 0.08% | – |
| ENTX | ENTERA BIO LTD | $3,129,000 | -53.7% | 2,353,000 | 0.0% | 0.08% | -43.5% | |
| BCAB | New | BIOATLA INC | $2,941,000 | – | 1,031,805 | +100.0% | 0.08% | – |
| Sell | ASTRIA THERAPEUTICS INC | $2,283,000 | -73.0% | 760,857 | -39.7% | 0.06% | -67.0% | |
| Sell | PYXIS ONCOLOGY INC | $2,269,000 | -75.4% | 953,393 | -58.2% | 0.06% | -70.1% | |
| ADVM | New | ADVERUM BIOTECHNOLOGIES INC | $2,071,000 | – | 1,726,019 | +100.0% | 0.06% | – |
| LRMR | Sell | LARIMAR THERAPEUTICS INC | $2,022,000 | -61.1% | 1,031,482 | -19.5% | 0.05% | -52.2% |
| ORTX | Sell | ORCHARD THERAPEUTICS PLCads | $1,776,000 | -74.3% | 3,040,885 | -68.6% | 0.05% | -68.9% |
| SNSE | New | SENSEI BIOTHERAPEUTICS | $1,642,000 | – | 723,549 | +100.0% | 0.04% | – |
| CVRX | CVRX INC | $1,653,000 | +0.4% | 275,000 | 0.0% | 0.04% | +22.2% | |
| OLMA | Sell | OLEMA PHARMACEUTICALS INC | $952,000 | -55.7% | 233,793 | -53.7% | 0.02% | -46.8% |
| BOLT | New | BOLT BIOTHERAPEUTICS INC | $918,000 | – | 450,141 | +100.0% | 0.02% | – |
| AVRO | New | AVROBIO INC | $515,000 | – | 559,600 | +100.0% | 0.01% | – |
| CLBS | New | CALADRIUS BIOSCIENCES | $399,000 | – | 752,500 | +100.0% | 0.01% | – |
| CMPX | Exit | COMPASS THERAPEUTICS INC | $0 | – | -532,958 | -100.0% | -0.02% | – |
| Exit | TSCAN THERAPEUTICS INC | $0 | – | -1,021,764 | -100.0% | -0.06% | – | |
| CGEM | Exit | CULLINAN ONCOLOGY INC | $0 | – | -350,000 | -100.0% | -0.08% | – |
| PHAS | Exit | PHASEBIO PHARMACEUTICALS INC | $0 | – | -2,850,000 | -100.0% | -0.08% | – |
| Exit | CUE HEALTH INC | $0 | – | -750,000 | -100.0% | -0.11% | – | |
| VERV | Exit | VERVE THERAPEUTICS INC | $0 | – | -310,284 | -100.0% | -0.16% | – |
| ALVR | Exit | ALLOVIR INC | $0 | – | -1,440,525 | -100.0% | -0.21% | – |
| AKUS | Exit | AKOUOS INC | $0 | – | -2,281,249 | -100.0% | -0.24% | – |
| MORF | Exit | MORPHIC HLDG INC | $0 | – | -278,874 | -100.0% | -0.24% | – |
| CYT | Exit | CYTEIR THERAPEUTICS INC | $0 | – | -3,350,506 | -100.0% | -0.28% | – |
| GRPH | Exit | GRAPHITE BIO INC | $0 | – | -2,698,369 | -100.0% | -0.30% | – |
| KALA | Exit | KALA PHARMACEUTICALS INC | $0 | – | -10,874,613 | -100.0% | -0.33% | – |
| SCPH | Exit | SCPHARMACEUTICALS INC | $0 | – | -2,658,583 | -100.0% | -0.33% | – |
| KDNY | Exit | CHINOOK THERAPEUTICS INC | $0 | – | -1,000,000 | -100.0% | -0.36% | – |
| Exit | TANGO THERAPEUTICS INC | $0 | – | -2,250,000 | -100.0% | -0.37% | – | |
| EWTX | Exit | EDGEWISE THERAPEUTICS INC | $0 | – | -2,613,623 | -100.0% | -0.55% | – |
| KALV | Exit | KALVISTA PHARMACEUTICALS INC | $0 | – | -1,930,322 | -100.0% | -0.62% | – |
| CCXI | Exit | CHEMOCENTRYX INC | $0 | – | -1,155,964 | -100.0% | -0.63% | – |
| CNTA | Exit | CENTESSA PHARMACEUTICALS PLCsponsored ads | $0 | – | -3,577,094 | -100.0% | -0.70% | – |
| NVAX | Exit | NOVAVAX INC | $0 | – | -692,794 | -100.0% | -1.11% | – |
| MGNX | Exit | MACROGENICS INC | $0 | – | -6,103,594 | -100.0% | -1.17% | – |
| MRTX | Exit | MIRATI THERAPEUTICS INC | $0 | – | -734,343 | -100.0% | -1.32% | – |
Original filings
The following EDGAR filing(s) were analyzed to create this report:
- View 13F-HR filed 2022-08-15
About RA Capital Management
RA Capital Management is a Boston-based investment management firm that specializes in the healthcare sector. The firm was founded in 2001 by Peter Kolchinsky, a former biotech analyst at Lehman Brothers. Since then, RA Capital has grown to become one of the most respected healthcare investment firms in the world, with over $5 billion in assets under management.
The firm's investment strategy is focused on identifying and investing in companies that are developing innovative therapies and technologies that have the potential to transform the healthcare industry. RA Capital's team of experienced analysts and portfolio managers conduct extensive research and due diligence to identify the most promising investment opportunities in the healthcare sector.
RA Capital's portfolio includes a diverse range of companies, from early-stage startups to established biotech and pharmaceutical companies. Some of the notable companies in RA Capital's portfolio include Moderna, a biotech company that is developing a COVID-19 vaccine, and Intellia Therapeutics, a gene editing company that is developing therapies for genetic diseases.
Peter Kolchinsky, the founder and CEO of RA Capital, is a well-respected figure in the healthcare investment community. He is a frequent speaker at industry conferences and has authored several books on biotech investing. Other key members of RA Capital's management team include Rajeev Shah, the firm's COO, and Derek DiRocco, the Chief Investment Officer.
Overall, RA Capital Management is a highly respected investment firm that has a proven track record of identifying and investing in innovative healthcare companies. Investors who are interested in the healthcare sector may want to consider RA Capital as a potential investment opportunity.
It's important to note that this information is for educational purposes only and has not been fact-checked. As with any investment, it's important to do your own research and consult with a financial advisor before making any investment decisions.
Top long-term holdings
| Name | Quarters owned | Latest quarter owned | Max weighting |
|---|---|---|---|
| ASCENDIS PHARMA A/S - ADR | 35 | Q3 2023 | 25.5% |
| WAVE LIFE SCIENCES PTE LTD | 32 | Q3 2023 | 26.3% |
| TG THERAPEUTICS INC | 30 | Q4 2021 | 6.3% |
| ZOGENIX INC | 26 | Q4 2021 | 9.5% |
| BIOCRYST PHARMACEUTICALS | 23 | Q1 2019 | 9.2% |
| DICERNA PHARMACEUTICALS INC | 23 | Q3 2019 | 5.8% |
| RHYTHM PHARMACEUTICALS INC | 22 | Q3 2023 | 4.4% |
| ACHILLION PHARMACEUTICALS INC | 19 | Q4 2017 | 17.2% |
| KALA PHARMACEUTICALS INC | 19 | Q1 2022 | 4.4% |
| SOLID BIOSCIENCES INC | 19 | Q3 2022 | 6.8% |
View RA Capital Management's complete holdings history.
Latest significant ownerships (13-D/G)
| Filed | Shares | Percentage | |
|---|---|---|---|
| CymaBay Therapeutics, Inc. | September 22, 2023 | 6,940,000 | 6.2% |
| BELLUS Health Inc.Sold out | August 14, 2023 | 0 | 0.0% |
| Kinnate Biopharma Inc.Sold out | August 14, 2023 | 0 | 0.0% |
| Vor Biopharma Inc. | August 11, 2023 | 22,780,343 | 33.7% |
| DICE Therapeutics, Inc.Sold out | August 09, 2023 | 0 | 0.0% |
| Acumen Pharmaceuticals, Inc. | July 25, 2023 | 14,981,618 | 25.9% |
| Talaris Therapeutics, Inc. | July 06, 2023 | 2,333,175 | 5.5% |
| Aerovate Therapeutics, Inc. | June 27, 2023 | 8,293,148 | 30.0% |
| Satsuma Pharmaceuticals, Inc.Sold out | June 12, 2023 | 0 | 0.0% |
| ARYA Sciences Acquisition Corp VSold out | May 15, 2023 | 0 | 0.0% |
View RA Capital Management's complete significant-ownership history.
Latest filings
| Type | Filed |
|---|---|
| 4 | 2024-04-15 |
| 4 | 2024-04-15 |
| SC 13G | 2024-04-15 |
| SC 13D/A | 2024-04-12 |
| SC 13G | 2024-04-12 |
| SC 13D/A | 2024-04-11 |
| SC 13G | 2024-04-11 |
| 4 | 2024-04-04 |
| SC 13G | 2024-04-04 |
| SC 13G | 2024-04-01 |
View RA Capital Management's complete filings history.
All filings
- Holdings (13F-HR)
- Significant ownership (13-D/G)
- Insider transactions (4, 5, 6)
- Events (8-K)
- Shareholder votes (proxy)
View complete filings history.