$4.58 Billion is the total value of RA Capital Management's 96 reported holdings in Q1 2022. The portfolio turnover from Q4 2021 to Q1 2022 was 21.6% .
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| ASND | ASCENDIS PHARMA A/Ssponsored adr | $888,169,000 | -12.8% | 7,567,900 | 0.0% | 19.38% | +8.0% | |
| BIIB | New | BIOGEN INC | $153,111,000 | – | 727,024 | +100.0% | 3.34% | – |
| AVTE | AEROVATE THERAPEUTICS INC | $151,479,000 | +55.5% | 8,263,982 | 0.0% | 3.30% | +92.4% | |
| Buy | CYTEK BIOSCIENCES INC | $144,248,000 | -8.0% | 13,381,054 | +39.3% | 3.15% | +13.9% | |
| ITOS | ITEOS THERAPEUTICS INC | $142,147,000 | -30.9% | 4,417,259 | 0.0% | 3.10% | -14.5% | |
| TVTX | Sell | TRAVERE THERAPEUTICS INC | $126,864,000 | -27.2% | 4,922,941 | -12.3% | 2.77% | -9.9% |
| JANX | JANUX THERAPEUTICS INC | $124,337,000 | -27.3% | 8,670,644 | 0.0% | 2.71% | -10.0% | |
| PCVX | Buy | VAXCYTE INC | $110,636,000 | +9.7% | 4,581,203 | +8.0% | 2.41% | +35.7% |
| ELIEM THERAPEUTICS INC | $110,336,000 | -19.8% | 13,150,849 | 0.0% | 2.41% | -0.7% | ||
| IMGN | Buy | IMMUNOGEN INC | $103,489,000 | -31.1% | 21,741,458 | +7.4% | 2.26% | -14.7% |
| DICE THERAPEUTICS INC | $99,646,000 | -24.4% | 5,208,911 | 0.0% | 2.17% | -6.5% | ||
| GHRS | Buy | GH RESEARCH PLCordinary shares | $88,292,000 | +33.1% | 4,827,330 | +69.8% | 1.93% | +64.6% |
| FMTX | FORMA THERAPEUTICS HLDGS INC | $83,808,000 | -34.6% | 9,011,651 | 0.0% | 1.83% | -19.0% | |
| TYRA BIOSCIENCES INC | $77,430,000 | -24.0% | 7,236,454 | 0.0% | 1.69% | -5.9% | ||
| PNT | POINT BIOPHARMA GLOBAL INC | $71,754,000 | +42.3% | 9,003,018 | 0.0% | 1.57% | +76.2% | |
| CLDX | Buy | CELLDEX THERAPEUTICS INC NEW | $70,675,000 | +1.3% | 2,075,000 | +15.0% | 1.54% | +25.4% |
| BLU | BELLUS HEALTH INC NEW | $70,384,000 | -14.5% | 10,230,274 | 0.0% | 1.54% | +5.8% | |
| ENTA | New | ENANTA PHARMACEUTICALS INC | $68,633,000 | – | 964,212 | +100.0% | 1.50% | – |
| VOR | VOR BIOPHARMA INC | $67,171,000 | -48.0% | 11,120,973 | 0.0% | 1.47% | -35.6% | |
| NKTX | NKARTA INC | $63,786,000 | -25.9% | 5,605,129 | 0.0% | 1.39% | -8.2% | |
| MRTX | Buy | MIRATI THERAPEUTICS INC | $60,378,000 | +8.0% | 734,343 | +92.7% | 1.32% | +33.7% |
| DAWN | Buy | DAY ONE BIOPHARMACEUTICALS I | $60,116,000 | -28.2% | 6,060,090 | +22.0% | 1.31% | -11.1% |
| RYTM | RHYTHM PHARMACEUTICALS INC | $56,115,000 | +15.4% | 4,871,067 | 0.0% | 1.22% | +42.8% | |
| New | AN2 THERAPEUTICS INC | $55,257,000 | – | 3,666,663 | +100.0% | 1.21% | – | |
| RLMD | RELMADA THERAPEUTICS INC | $53,980,000 | +19.8% | 2,000,000 | 0.0% | 1.18% | +48.4% | |
| MGNX | MACROGENICS INC | $53,773,000 | -45.1% | 6,103,594 | 0.0% | 1.17% | -32.1% | |
| NTRA | New | NATERA INC | $53,303,000 | – | 1,310,289 | +100.0% | 1.16% | – |
| TIL | INSTIL BIO INC | $52,361,000 | -37.2% | 4,870,793 | 0.0% | 1.14% | -22.3% | |
| NVAX | Sell | NOVAVAX INC | $51,024,000 | -83.0% | 692,794 | -67.0% | 1.11% | -79.0% |
| KNTE | Buy | KINNATE BIOPHARMA INC | $48,014,000 | -24.6% | 4,264,144 | +18.7% | 1.05% | -6.7% |
| VERA | New | VERA THERAPEUTICS INCcl a | $46,183,000 | – | 1,966,084 | +100.0% | 1.01% | – |
| Buy | PARDES BIOSCIENCES INC | $44,584,000 | -12.9% | 6,175,038 | +97.5% | 0.97% | +7.8% | |
| Buy | ICOSAVAX INC | $41,983,000 | -68.3% | 5,963,565 | +3.2% | 0.92% | -60.7% | |
| TENAYA THERAPEUTICS INC | $41,837,000 | -37.8% | 3,551,508 | 0.0% | 0.91% | -23.1% | ||
| EYPT | EYEPOINT PHARMACEUTICALS INC | $40,952,000 | -0.7% | 3,370,506 | 0.0% | 0.89% | +23.0% | |
| GERN | GERON CORP | $40,972,000 | +11.5% | 30,126,299 | 0.0% | 0.89% | +38.0% | |
| RNA | Buy | AVIDITY BIOSCIENCES INC | $40,032,000 | +297.6% | 2,167,391 | +411.6% | 0.87% | +390.4% |
| ABOS | ACUMEN PHARMACEUTICALS INC | $38,204,000 | -42.2% | 9,770,773 | 0.0% | 0.83% | -28.4% | |
| RXSIGHT INC | $37,794,000 | +10.0% | 3,052,796 | 0.0% | 0.82% | +36.1% | ||
| PMVP | PMV PHARMACEUTICALS INC | $35,608,000 | -9.9% | 1,710,265 | 0.0% | 0.78% | +11.5% | |
| DSGN | DESIGN THERAPEUTICS INC | $35,314,000 | -24.6% | 2,186,636 | 0.0% | 0.77% | -6.5% | |
| RCKT | ROCKET PHARMACEUTICALS INC | $33,419,000 | -27.3% | 2,107,149 | 0.0% | 0.73% | -10.1% | |
| CNTA | CENTESSA PHARMACEUTICALS PLCsponsored ads | $32,087,000 | -20.3% | 3,577,094 | 0.0% | 0.70% | -1.4% | |
| GH | New | GUARDANT HEALTH INC | $31,555,000 | – | 476,380 | +100.0% | 0.69% | – |
| ACRS | New | ACLARIS THERAPEUTICS INC | $31,339,000 | – | 1,817,808 | +100.0% | 0.68% | – |
| CCXI | New | CHEMOCENTRYX INC | $28,980,000 | – | 1,155,964 | +100.0% | 0.63% | – |
| KALV | KALVISTA PHARMACEUTICALS INC | $28,453,000 | +11.4% | 1,930,322 | 0.0% | 0.62% | +38.0% | |
| LIANBIOsponsored ads | $28,400,000 | -39.8% | 7,655,015 | 0.0% | 0.62% | -25.4% | ||
| DYN | DYNE THERAPEUTICS INC | $27,041,000 | -18.9% | 2,805,045 | 0.0% | 0.59% | +0.3% | |
| VRNA | VERONA PHARMA PLCsponsored ads | $25,449,000 | -25.7% | 5,100,000 | 0.0% | 0.56% | -8.1% | |
| EWTX | EDGEWISE THERAPEUTICS INC | $25,352,000 | -36.5% | 2,613,623 | 0.0% | 0.55% | -21.4% | |
| STSA | SATSUMA PHARMACEUTICALS INC | $22,474,000 | -15.6% | 5,914,252 | 0.0% | 0.49% | +4.5% | |
| CNTB | CONNECT BIOPHARMA HLDGS LTDads | $21,113,000 | -41.4% | 6,991,003 | 0.0% | 0.46% | -27.4% | |
| HOWL | WEREWOLF THERAPEUTICS INC | $18,884,000 | -63.1% | 4,291,881 | 0.0% | 0.41% | -54.3% | |
| ETNB | 89BIO INC | $18,721,000 | -71.2% | 4,965,769 | 0.0% | 0.41% | -64.3% | |
| TANGO THERAPEUTICS INC | $17,055,000 | -30.7% | 2,250,000 | 0.0% | 0.37% | -14.3% | ||
| RLAY | RELAY THERAPEUTICS INC | $16,433,000 | -2.5% | 549,055 | 0.0% | 0.36% | +20.9% | |
| KDNY | CHINOOK THERAPEUTICS INC | $16,360,000 | +0.3% | 1,000,000 | 0.0% | 0.36% | +24.0% | |
| SYBX | SYNLOGIC INC | $16,000,000 | -0.8% | 6,666,666 | 0.0% | 0.35% | +22.9% | |
| WVE | WAVE LIFE SCIENCES LTD | $15,550,000 | -36.3% | 7,775,207 | 0.0% | 0.34% | -21.2% | |
| SCPH | Sell | SCPHARMACEUTICALS INC | $15,101,000 | +11.8% | 2,658,583 | -1.2% | 0.33% | +38.2% |
| KALA | KALA PHARMACEUTICALS INC | $15,007,000 | +14.1% | 10,874,613 | 0.0% | 0.33% | +40.9% | |
| SLDB | SOLID BIOSCIENCES INC | $14,841,000 | -31.4% | 12,367,873 | 0.0% | 0.32% | -15.2% | |
| ACHL | ACHILLES THERAPEUTICS PLCsponsored ads | $14,743,000 | -41.3% | 5,014,687 | 0.0% | 0.32% | -27.3% | |
| DA32 LIFE SCNCE TEC ACQSTN C | $14,573,000 | -1.0% | 1,500,000 | 0.0% | 0.32% | +22.8% | ||
| MIST | MILESTONE PHARMACEUTICALS IN | $14,423,000 | -2.0% | 2,246,503 | 0.0% | 0.32% | +21.6% | |
| XILIO THERAPEUTICS INC | $14,156,000 | -55.8% | 2,002,217 | 0.0% | 0.31% | -45.3% | ||
| GRPH | GRAPHITE BIO INC | $13,762,000 | -59.0% | 2,698,369 | 0.0% | 0.30% | -49.2% | |
| OTIC | OTONOMY INC | $13,440,000 | +15.4% | 5,600,000 | 0.0% | 0.29% | +42.9% | |
| CYT | CYTEIR THERAPEUTICS INC | $12,631,000 | -66.8% | 3,350,506 | 0.0% | 0.28% | -58.9% | |
| BLSA | BCLS ACQUISITION CORP | $12,338,000 | +0.7% | 1,250,000 | 0.0% | 0.27% | +24.5% | |
| IPSC | CENTURY THERAPEUTICS INC | $11,508,000 | -20.6% | 914,094 | 0.0% | 0.25% | -2.0% | |
| MORF | New | MORPHIC HLDG INC | $11,197,000 | – | 278,874 | +100.0% | 0.24% | – |
| AKUS | AKOUOS INC | $10,836,000 | -44.1% | 2,281,249 | 0.0% | 0.24% | -31.0% | |
| CNCE | CONCERT PHARMACEUTICALS INC | $10,223,000 | +7.0% | 3,033,603 | 0.0% | 0.22% | +32.7% | |
| FLACU | FRAZIER LIFESCIENCES ACQU CO | $9,990,000 | +0.7% | 1,000,000 | 0.0% | 0.22% | +24.6% | |
| IO BIOTECH INC | $9,846,000 | -17.2% | 1,857,755 | 0.0% | 0.22% | +2.4% | ||
| ARYA SCIENCES ACQUISITN | $9,710,000 | +0.1% | 1,000,000 | 0.0% | 0.21% | +24.0% | ||
| ALVR | New | ALLOVIR INC | $9,724,000 | – | 1,440,525 | +100.0% | 0.21% | – |
| PYXIS ONCOLOGY INC | $9,220,000 | -63.2% | 2,282,173 | 0.0% | 0.20% | -54.4% | ||
| ASTRIA THERAPEUTICS INC | $8,469,000 | +24.5% | 1,262,193 | 0.0% | 0.18% | +54.2% | ||
| FVAM | 5 01 ACQUISITION CORP | $7,388,000 | 0.0% | 750,000 | 0.0% | 0.16% | +23.8% | |
| BDTX | BLACK DIAMOND THERAPEUTICS I | $7,174,000 | -48.0% | 2,589,904 | 0.0% | 0.16% | -35.4% | |
| VERV | VERVE THERAPEUTICS INC | $7,081,000 | -38.1% | 310,284 | 0.0% | 0.16% | -23.3% | |
| ORTX | ORCHARD THERAPEUTICS PLCads | $6,903,000 | -46.1% | 9,694,789 | 0.0% | 0.15% | -33.2% | |
| ENTX | ENTERA BIO LTD | $6,753,000 | +1.9% | 2,353,000 | 0.0% | 0.15% | +25.6% | |
| HSAQ | HEALTH SCIENCES ACQ CORP 2 | $6,194,000 | -1.7% | 625,000 | 0.0% | 0.14% | +21.6% | |
| LRMR | Sell | LARIMAR THERAPEUTICS INC | $5,192,000 | -63.9% | 1,281,860 | -4.0% | 0.11% | -55.5% |
| CUE HEALTH INC | $4,838,000 | -51.9% | 750,000 | 0.0% | 0.11% | -40.1% | ||
| PHAS | PHASEBIO PHARMACEUTICALS INC | $3,762,000 | -49.4% | 2,850,000 | 0.0% | 0.08% | -37.4% | |
| CGEM | CULLINAN ONCOLOGY INC | $3,665,000 | -32.1% | 350,000 | 0.0% | 0.08% | -15.8% | |
| Sell | TSCAN THERAPEUTICS INC | $2,861,000 | -49.4% | 1,021,764 | -18.6% | 0.06% | -38.0% | |
| BMEA | BIOMEA FUSION INC | $2,230,000 | -40.1% | 500,000 | 0.0% | 0.05% | -25.8% | |
| OLMA | Sell | OLEMA PHARMACEUTICALS INC | $2,149,000 | -89.3% | 504,505 | -76.5% | 0.05% | -86.8% |
| CVRX | CVRX INC | $1,647,000 | -51.0% | 275,000 | 0.0% | 0.04% | -39.0% | |
| CMPX | Sell | COMPASS THERAPEUTICS INC | $730,000 | -87.5% | 532,958 | -71.2% | 0.02% | -84.5% |
| SYRS | Exit | SYROS PHARMACEUTICALS INC | $0 | – | -900,000 | -100.0% | -0.05% | – |
| COGT | Exit | COGENT BIOSCIENCES INC | $0 | – | -1,025,641 | -100.0% | -0.16% | – |
| IKNA | Exit | IKENA ONCOLOGY INC | $0 | – | -750,000 | -100.0% | -0.17% | – |
| SBTX | Exit | SILVERBACK THERAPEUTICS INC | $0 | – | -1,742,186 | -100.0% | -0.20% | – |
| BOLT | Exit | BOLT BIOTHERAPEUTICS INC | $0 | – | -2,378,325 | -100.0% | -0.20% | – |
| NAUT | Exit | NAUTILUS | $0 | – | -2,436,430 | -100.0% | -0.22% | – |
| Exit | ADAGIO THERAPEUTICS INC | $0 | – | -4,995,807 | -100.0% | -0.64% | – | |
| TGTX | Exit | TG THERAPEUTICS INC | $0 | – | -2,210,145 | -100.0% | -0.74% | – |
| CCCC | Exit | C4 THERAPEUTICS INC | $0 | – | -1,377,569 | -100.0% | -0.78% | – |
| ZGNX | Exit | ZOGENIX INC | $0 | – | -3,333,700 | -100.0% | -0.96% | – |
| PHAT | Exit | PHATHOM PHARMACEUTICALS INC | $0 | – | -3,115,008 | -100.0% | -1.08% | – |
Original filings
The following EDGAR filing(s) were analyzed to create this report:
- View 13F-HR filed 2022-05-16
About RA Capital Management
RA Capital Management is a Boston-based investment management firm that specializes in the healthcare sector. The firm was founded in 2001 by Peter Kolchinsky, a former biotech analyst at Lehman Brothers. Since then, RA Capital has grown to become one of the most respected healthcare investment firms in the world, with over $5 billion in assets under management.
The firm's investment strategy is focused on identifying and investing in companies that are developing innovative therapies and technologies that have the potential to transform the healthcare industry. RA Capital's team of experienced analysts and portfolio managers conduct extensive research and due diligence to identify the most promising investment opportunities in the healthcare sector.
RA Capital's portfolio includes a diverse range of companies, from early-stage startups to established biotech and pharmaceutical companies. Some of the notable companies in RA Capital's portfolio include Moderna, a biotech company that is developing a COVID-19 vaccine, and Intellia Therapeutics, a gene editing company that is developing therapies for genetic diseases.
Peter Kolchinsky, the founder and CEO of RA Capital, is a well-respected figure in the healthcare investment community. He is a frequent speaker at industry conferences and has authored several books on biotech investing. Other key members of RA Capital's management team include Rajeev Shah, the firm's COO, and Derek DiRocco, the Chief Investment Officer.
Overall, RA Capital Management is a highly respected investment firm that has a proven track record of identifying and investing in innovative healthcare companies. Investors who are interested in the healthcare sector may want to consider RA Capital as a potential investment opportunity.
It's important to note that this information is for educational purposes only and has not been fact-checked. As with any investment, it's important to do your own research and consult with a financial advisor before making any investment decisions.
Top long-term holdings
| Name | Quarters owned | Latest quarter owned | Max weighting |
|---|---|---|---|
| ASCENDIS PHARMA A/S - ADR | 35 | Q3 2023 | 25.5% |
| WAVE LIFE SCIENCES PTE LTD | 32 | Q3 2023 | 26.3% |
| TG THERAPEUTICS INC | 30 | Q4 2021 | 6.3% |
| ZOGENIX INC | 26 | Q4 2021 | 9.5% |
| BIOCRYST PHARMACEUTICALS | 23 | Q1 2019 | 9.2% |
| DICERNA PHARMACEUTICALS INC | 23 | Q3 2019 | 5.8% |
| RHYTHM PHARMACEUTICALS INC | 22 | Q3 2023 | 4.4% |
| ACHILLION PHARMACEUTICALS INC | 19 | Q4 2017 | 17.2% |
| KALA PHARMACEUTICALS INC | 19 | Q1 2022 | 4.4% |
| SOLID BIOSCIENCES INC | 19 | Q3 2022 | 6.8% |
View RA Capital Management's complete holdings history.
Latest significant ownerships (13-D/G)
| Filed | Shares | Percentage | |
|---|---|---|---|
| CymaBay Therapeutics, Inc. | September 22, 2023 | 6,940,000 | 6.2% |
| BELLUS Health Inc.Sold out | August 14, 2023 | 0 | 0.0% |
| Kinnate Biopharma Inc.Sold out | August 14, 2023 | 0 | 0.0% |
| Vor Biopharma Inc. | August 11, 2023 | 22,780,343 | 33.7% |
| DICE Therapeutics, Inc.Sold out | August 09, 2023 | 0 | 0.0% |
| Acumen Pharmaceuticals, Inc. | July 25, 2023 | 14,981,618 | 25.9% |
| Talaris Therapeutics, Inc. | July 06, 2023 | 2,333,175 | 5.5% |
| Aerovate Therapeutics, Inc. | June 27, 2023 | 8,293,148 | 30.0% |
| Satsuma Pharmaceuticals, Inc.Sold out | June 12, 2023 | 0 | 0.0% |
| ARYA Sciences Acquisition Corp VSold out | May 15, 2023 | 0 | 0.0% |
View RA Capital Management's complete significant-ownership history.
Latest filings
| Type | Filed |
|---|---|
| 4 | 2024-04-15 |
| 4 | 2024-04-15 |
| SC 13G | 2024-04-15 |
| SC 13D/A | 2024-04-12 |
| SC 13G | 2024-04-12 |
| SC 13D/A | 2024-04-11 |
| SC 13G | 2024-04-11 |
| 4 | 2024-04-04 |
| SC 13G | 2024-04-04 |
| SC 13G | 2024-04-01 |
View RA Capital Management's complete filings history.
All filings
- Holdings (13F-HR)
- Significant ownership (13-D/G)
- Insider transactions (4, 5, 6)
- Events (8-K)
- Shareholder votes (proxy)
View complete filings history.