Name,Ticker,Title of class,Class,Change,CUSIP,Value,Shares or principal amount,Weighting ASCENDIS PHARMA A/S,ASND,, ,04351P101,745948732.0,6957179.0,16.887 VAXCYTE INC,PCVX,,Buy,92243G108,273276200.0,7291254.0,6.186 DICE THERAPEUTICS INC,,,Buy,23345J104,225091934.0,7856612.0,5.096 89BIO INC,ETNB,,Buy,282559103,173880118.0,11416948.0,3.936 AEROVATE THERAPEUTICS INC,AVTE,, ,008064107,166684517.0,8263982.0,3.773 BIOGEN INC,BIIB,, ,09062X103,148159963.0,532892.0,3.354 VERONA PHARMA PLC,VRNA,, ,925050106,126865239.0,6317990.0,2.872 CYTEK BIOSCIENCES INC,,sponsored adr, ,23285D109,122971886.0,13381054.0,2.784 VOR BIOPHARMA INC,VOR,, ,929033108,122388974.0,22748880.0,2.771 LEGEND BIOTECH CORP,LEGN,, ,52490G102,117474673.0,2436223.0,2.659 TYRA BIOSCIENCES INC,,, ,90240B106,116289816.0,7236454.0,2.633 JANUX THERAPEUTICS INC,JANX,, ,47103J105,104914792.0,8670644.0,2.375 PEPGEN INC,,, ,713317105,99453773.0,8131952.0,2.251 AVIDITY BIOSCIENCES INC,RNA,,Buy,05370A108,98500919.0,6416998.0,2.23 RHYTHM PHARMACEUTICALS INC,RYTM,, ,76243J105,98406635.0,5516067.0,2.228 DAY ONE BIOPHARMACEUTICALS I,DAWN,, ,23954D109,94133116.0,7040622.0,2.131 BELLUS HEALTH INC NEW,BLU,,Buy,07987C204,91033733.0,12643574.0,2.061 CUREVAC N V,CVAC,sponsored ads,New,N2451R105,85354306.0,12245955.0,1.932 IMMUNOGEN INC,IMGN,, ,45253H101,83919199.0,21853958.0,1.9 WAVE LIFE SCIENCES LTD,WVE,, ,Y95308105,74484699.0,17202009.0,1.686 INHIBRX INC,INBX,, ,45720L107,72722470.0,3853867.0,1.646 GERON CORP,GERN,ads,Buy,374163103,68452229.0,31544806.0,1.55 COGENT COMMUNICATIONS HLDGS,COGT,, ,19240Q201,64734400.0,5999481.0,1.465 CELLDEX THERAPEUTICS INC NEW,CLDX,,Sell,15117B202,62424293.0,1734972.0,1.413 ACRIVON THERAPEUTICS INC,,, ,004890109,61045347.0,4810508.0,1.382 ITEOS THERAPEUTICS INC,ITOS,sponsored adr, ,46565G104,60118895.0,4417259.0,1.361 NEWAMSTERDAM PHARMA COMPANY,,, ,N62509109,53040000.0,4000000.0,1.201 VIRIDIAN THERAPEUTICS INC,VRDN,,Buy,92790C104,51082146.0,2007946.0,1.156 RXSIGHT INC,,ordinary shares, ,78349D107,50920637.0,3052796.0,1.153 MINERALYS THERAPEUTICS INC,,,New,603170101,49774934.0,3178476.0,1.127 PLIANT THERAPEUTICS INC,PLRX,,New,729139105,46869200.0,1762000.0,1.061 ENLIVEN THERAPEUTICS INC,,,New,29337E102,46481984.0,2122465.0,1.052 GH RESEARCH PLC,GHRS,,Buy,G3855L106,44593476.0,5581161.0,1.009 ACUMEN PHARMACEUTICALS INC,ABOS,sponsored ads, ,00509G209,39669338.0,9770773.0,0.898 ELIEM THERAPEUTICS INC,,, ,28658R106,38137462.0,13150849.0,0.863 AN2 THERAPEUTICS INC,,, ,037326105,37244613.0,3773517.0,0.843 ALPINE IMMUNE SCIENCES INC,ALPN,,Buy,02083G100,36192248.0,4688115.0,0.819 ACLARIS THERAPEUTICS INC,ACRS,, ,00461U105,35583485.0,4398453.0,0.806 ICOSAVAX INC,,, ,45114M109,34588677.0,5963565.0,0.783 FULCRUM THERAPEUTICS INC,FULC,,Buy,359616109,33087656.0,11609704.0,0.749 HILLEVAX INC,,, ,43157M102,29093114.0,1760019.0,0.659 NKARTA INC,NKTX,, ,65487U108,27708208.0,7805129.0,0.627 KINNATE BIOPHARMA INC,KNTE,, ,49705R105,26650900.0,4264144.0,0.603 NANOSTRING TECHNOLOGIES,NSTG,,Buy,63009R109,24327003.0,2457273.0,0.551 ARS PHARMACEUTICALS INC,SBTX,, ,82835W108,19593004.0,3009678.0,0.444 ROCKET PHARMACEUTICALS INC,RCKT,,Sell,77313F106,19387306.0,1131775.0,0.439 TENAYA THERAPEUTICS INC,,, ,87990A106,17292327.0,6067483.0,0.391 DESIGN THERAPEUTICS INC,DSGN,, ,25056L103,17144003.0,2971231.0,0.388 SOLID BIOSCIENCES INC,,, ,83422E204,16240596.0,3426286.0,0.368 WEREWOLF THERAPEUTICS INC,HOWL,,Buy,95075A107,15976691.0,6144881.0,0.362 CELCUITY INC,CELC,, ,15102K100,14350010.0,1400001.0,0.325 EYEPOINT PHARMACEUTICALS INC,EYPT,, ,30233G209,9909288.0,3370506.0,0.224 CONNECT BIOPHARMA HLDGS LTD,CNTB,, ,207523101,6990304.0,6991003.0,0.158 BLACK DIAMOND THERAPEUTICS I,BDTX,, ,09203E105,4894919.0,2589904.0,0.111 AADI BIOSCIENCE INC,,, ,00032Q104,4273178.0,590218.0,0.097 SATSUMA PHARMACEUTICALS INC,STSA,, ,80405P107,4131105.0,5914252.0,0.094 FUSION PHARMACEUTICALS INC,FUSN,, ,36118A100,2488170.0,659992.0,0.056 NEWAMSTERDAM PHARMA COMPANY,,*w exp 11/22/202, ,N62509117,613333.0,333333.0,0.014 ENTERA BIO LTD,ENTX,, ,M40527109,343321.0,295966.0,0.008 IMMUNIC INC,IMUX,,Exit,4525EP101,0.0,-632184.0,-0.018 ACHILLES THERAPEUTICS PLC,ACHL,sponsored ads,Exit,00449L102,0.0,-1607834.0,-0.029 THIRD HARMONIC BIO INC,,,Exit,88427A107,0.0,-534687.0,-0.047 IO BIOTECH INC,,,Exit,449778109,0.0,-1127260.0,-0.053 DBV TECHNOLOGIES S A,DBVT,sponsored adr,Exit,23306J101,0.0,-1958957.0,-0.061 CVRX INC,CVRX,,Exit,126638105,0.0,-275000.0,-0.102 ATHIRA PHARMA INC,ATHA,,Exit,04746L104,0.0,-1881300.0,-0.121 HEALTH SCIENCES ACQ CORP 2,HSAQ,,Exit,G4411D109,0.0,-610283.0,-0.124 CONCERT PHARMACEUTICALS INC,CNCE,,Exit,206022105,0.0,-1088296.0,-0.129 ARYA SCIENCES ACQUISITN CORP,,,Exit,G31658100,0.0,-1000000.0,-0.205 IMARA INC,IMRA,,Exit,45249V107,0.0,-3250724.0,-0.27 SCPHARMACEUTICALS INC,SCPH,,Exit,810648105,0.0,-1856904.0,-0.27 DA32 LIFE SCNCE,,,Exit,23312M106,0.0,-1500000.0,-0.304 AKERO THERAPEUTICS INC,AKRO,,Exit,00973Y108,0.0,-958980.0,-1.066 TRAVERE THERAPEUTICS INC,TVTX,,Exit,89422G107,0.0,-3984681.0,-1.7