Name,Ticker,Title of class,Class,Change,CUSIP,Value,Shares or principal amount,Weighting ASCENDIS PHARMA A/S,ASND,sponsored adr, ,04351P101,781462000.0,7567900.0,16.671 BIOGEN INC,BIIB,,Buy,09062X103,250325000.0,937549.0,5.34 CYTEK BIOSCIENCES INC,,, ,23285D109,196969000.0,13381054.0,4.202 FORMA THERAPEUTICS HLDGS INC,FMTX,, ,34633R104,179782000.0,9011651.0,3.835 DAY ONE BIOPHARMACEUTICALS I,DAWN,, ,23954D109,141024000.0,7040622.0,3.008 AEROVATE THERAPEUTICS INC,AVTE,, ,008064107,137017000.0,8263982.0,2.923 RHYTHM PHARMACEUTICALS INC,RYTM,,Buy,76243J105,134041000.0,5471067.0,2.86 TRAVERE THERAPEUTICS INC,TVTX,, ,89422G107,121301000.0,4922941.0,2.588 BELLUS HEALTH INC NEW,BLU,,Buy,07987C204,120232000.0,11385574.0,2.565 JANUX THERAPEUTICS INC,JANX,, ,47103J105,117401000.0,8670644.0,2.505 VAXCYTE INC,PCVX,, ,92243G108,109949000.0,4581203.0,2.346 DICE THERAPEUTICS INC,,, ,23345J104,105637000.0,5208911.0,2.254 IMMUNOGEN INC,IMGN,, ,45253H101,103924000.0,21741458.0,2.217 NKARTA INC,NKTX,, ,65487U108,102716000.0,7805129.0,2.191 ACUMEN PHARMACEUTICALS INC,ABOS,, ,00509G209,98001000.0,9770773.0,2.091 LEGEND BIOTECH CORP,LEGN,sponsored ads,New,52490G102,95415000.0,2338610.0,2.036 ITEOS THERAPEUTICS INC,ITOS,, ,46565G104,84149000.0,4417259.0,1.795 RELMADA THERAPEUTICS INC,RLMD,, ,75955J402,74040000.0,2000000.0,1.58 PEPGEN INC,,, ,713317105,73838000.0,8131952.0,1.575 GERON CORP,GERN,, ,374163103,70496000.0,30126299.0,1.504 ACLARIS THERAPEUTICS INC,ACRS,, ,00461U105,69231000.0,4398453.0,1.477 THIRD HARMONIC BIO INC,,,New,88427A107,65934000.0,3475687.0,1.407 AN2 THERAPEUTICS INC,,,Buy,037326105,65584000.0,3773517.0,1.399 TYRA BIOSCIENCES INC,,, ,90240B106,63609000.0,7236454.0,1.357 WAVE LIFE SCIENCES LTD,WVE,, ,Y95308105,62099000.0,17202009.0,1.325 VERONA PHARMA PLC,VRNA,sponsored ads,Buy,925050106,61831000.0,6050000.0,1.319 COGENT COMMUNICATIONS HLDGS,COGT,,New,19240Q201,59881000.0,4013453.0,1.277 NANOSTRING TECHNOLOGIES,NSTG,,Buy,63009R109,58774000.0,4602478.0,1.254 CELLDEX THERAPEUTICS INC NEW,CLDX,, ,15117B202,58328000.0,2075000.0,1.244 GH RESEARCH PLC,GHRS,ordinary shares, ,G3855L106,56919000.0,4898373.0,1.214 FULCRUM THERAPEUTICS INC,FULC,,New,359616109,56630000.0,7000000.0,1.208 KINNATE BIOPHARMA INC,KNTE,, ,49705R105,50956000.0,4264144.0,1.087 ENANTA PHARMACEUTICALS INC,ENTA,, ,29251M106,46513000.0,896724.0,0.992 DESIGN THERAPEUTICS INC,DSGN,,Buy,25056L103,46368000.0,2773231.0,0.989 89BIO INC,ETNB,, ,282559103,45062000.0,7782669.0,0.961 VOR BIOPHARMA INC,VOR,, ,929033108,44261000.0,11120973.0,0.944 ELIEM THERAPEUTICS INC,,, ,28658R106,42477000.0,13150849.0,0.906 INSTIL BIO INC,TIL,, ,45783C101,37127000.0,7670793.0,0.792 RXSIGHT INC,,, ,78349D107,36633000.0,3052796.0,0.781 SATSUMA PHARMACEUTICALS INC,STSA,, ,80405P107,35486000.0,5914252.0,0.757 AVIDITY BIOSCIENCES INC,RNA,, ,05370A108,35393000.0,2167391.0,0.755 VERA THERAPEUTICS INC,VERA,cl a, ,92337R101,33645000.0,1578820.0,0.718 ROCKET PHARMACEUTICALS INC,RCKT,, ,77313F106,33630000.0,2107149.0,0.717 AKERO THERAPEUTICS INC,AKRO,,New,00973Y108,32653000.0,958980.0,0.697 ALPINE IMMUNE SCIENCES INC,ALPN,,New,02083G100,31368000.0,4356632.0,0.669 HILLEVAX INC,,, ,43157M102,30079000.0,1760019.0,0.642 ADICET BIO INC,ACET,,New,007002108,29284000.0,2059372.0,0.625 EYEPOINT PHARMACEUTICALS INC,EYPT,, ,30233G209,26660000.0,3370506.0,0.569 MILESTONE PHARMACEUTICALS IN,MIST,, ,59935V107,20645000.0,2246503.0,0.44 PMV PHARMACEUTICALS INC,PMVP,, ,69353Y103,20352000.0,1710265.0,0.434 WEREWOLF THERAPEUTICS INC,HOWL,, ,95075A107,19356000.0,4291881.0,0.413 ICOSAVAX INC,,, ,45114M109,18845000.0,5963565.0,0.402 VIRIDIAN THERAPEUTICS INC,VRDN,sponsored ads,New,92790C104,18049000.0,880000.0,0.385 RELAY THERAPEUTICS INC,RLAY,,Buy,75943R102,16053000.0,717618.0,0.342 DA32 LIFE SCNCE,,, ,23312M106,14595000.0,1500000.0,0.311 BCLS ACQUISITION CORP,BLSA,, ,G0904B105,12525000.0,1250000.0,0.267 PARDES BIOSCIENCES INC,,, ,69945Q105,11424000.0,6175038.0,0.244 ACHILLES THERAPEUTICS PLC,ACHL,sponsored ads, ,00449L102,11333000.0,5014687.0,0.242 FRAZIER LIFESCIENCES ACQU CO,FLACU,, ,G3710A121,9980000.0,1000000.0,0.213 ARYA SCIENCES ACQUISITN CORP,,, ,G31658100,9800000.0,1000000.0,0.209 CONNECT BIOPHARMA HLDGS LTD,CNTB,ads, ,207523101,9018000.0,6991003.0,0.192 AADI BIOSCIENCE INC,,,Buy,00032Q104,8340000.0,590218.0,0.178 5 01 ACQUISITION CORP,FVAM,, ,33836P105,7500000.0,750000.0,0.16 CONCERT PHARMACEUTICALS INC,CNCE,,Sell,206022105,7292000.0,1088296.0,0.156 DBV TECHNOLOGIES S A,DBVT,sponsored adr,New,23306J101,6593000.0,3724740.0,0.141 HEALTH SCIENCES ACQ CORP 2,HSAQ,,Sell,G4411D109,6042000.0,610283.0,0.129 SOLID BIOSCIENCES INC,SLDB,, ,83422E105,5771000.0,12367873.0,0.123 ATHIRA PHARMA INC,ATHA,, ,04746L104,5578000.0,1878000.0,0.119 MAGENTA THERAPEUTICS INC,MGTA,,New,55910K108,5059000.0,3588081.0,0.108 IO BIOTECH INC,,, ,449778109,5035000.0,1857755.0,0.107 TENAYA THERAPEUTICS INC,,,Sell,87990A106,4646000.0,1602009.0,0.099 SYNLOGIC INC,SYBX,,Sell,87166L100,4387000.0,4618415.0,0.094 BLACK DIAMOND THERAPEUTICS I,BDTX,, ,09203E105,4377000.0,2589904.0,0.093 CVRX INC,CVRX,, ,126638105,2566000.0,275000.0,0.055 ENTERA BIO LTD,ENTX,,Sell,M40527109,2166000.0,2082372.0,0.046 FUSION PHARMACEUTICALS INC,FUSN,,New,36118A100,1987000.0,659992.0,0.042 PYXIS ONCOLOGY INC,,,Sell,747324101,1506000.0,764653.0,0.032 SENSEI BIOTHERAPEUTICS,SNSE,,Sell,81728A108,1059000.0,683529.0,0.023 BOLT BIOTHERAPEUTICS INC,BOLT,,Buy,097702104,789000.0,533432.0,0.017 APTINYX INC,APTX,,New,03836N103,720000.0,1954698.0,0.015 AEGLEA BIOTHERAPEUTICS INC,AGLE,,New,00773J103,5000.0,10439.0,0.0 CALADRIUS BIOSCIENCES,CLBS,,Exit,128058203,0.0,-752500.0,-0.011 AVROBIO INC,AVRO,,Exit,05455M100,0.0,-559600.0,-0.014 OLEMA PHARMACEUTICALS INC,OLMA,,Exit,68062P106,0.0,-233793.0,-0.025 ORCHARD THERAPEUTICS PLC,ORTX,ads,Exit,68570P101,0.0,-3040885.0,-0.047 LARIMAR THERAPEUTICS INC,LRMR,,Exit,517125100,0.0,-1031482.0,-0.054 ADVERUM BIOTECHNOLOGIES INC,ADVM,,Exit,00773U108,0.0,-1726019.0,-0.055 ASTRIA THERAPEUTICS INC,,,Exit,04635X102,0.0,-760857.0,-0.061 BIOATLA INC,BCAB,,Exit,09077B104,0.0,-1031805.0,-0.078 TERNS PHARMACEUTICALS INC,TERN,,Exit,880881107,0.0,-1261435.0,-0.083 STANDARD BIOTOOLS INC,FLDM,,Exit,34385P108,0.0,-1987589.0,-0.085 XILIO THERAPEUTICS INC,,,Exit,98422T100,0.0,-1649711.0,-0.128 BIOMEA FUSION INC,BMEA,,Exit,09077A106,0.0,-500000.0,-0.16 CENTURY THERAPEUTICS INC,IPSC,,Exit,15673T100,0.0,-756821.0,-0.169 LIANBIO,,sponsored ads,Exit,53000N108,0.0,-4622574.0,-0.266 OTONOMY INC,OTIC,,Exit,68906L105,0.0,-5600000.0,-0.311 GUARDANT HEALTH INC,GH,,Exit,40131M109,0.0,-476380.0,-0.512 DYNE THERAPEUTICS INC,DYN,,Exit,26818M108,0.0,-2805045.0,-0.514 NATERA INC,NTRA,,Exit,632307104,0.0,-1310289.0,-1.238 POINT BIOPHARMA GLOBAL INC,PNT,,Exit,730541109,0.0,-9003018.0,-1.635 VERU INC,VERU,,Exit,92536C103,0.0,-7900000.0,-2.38