$15.3 Billion is the total value of Baker Brothers Advisors's 115 reported holdings in Q3 2022. The portfolio turnover from Q2 2022 to Q3 2022 was 22.2% .
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| SGEN | Seagen Inc. | $6,419,005,000 | -22.7% | 46,912,266 | 0.0% | 42.04% | -10.7% | |
| INCY | Buy | Incyte Corporation | $2,409,341,000 | -12.3% | 36,154,574 | +0.0% | 15.78% | +1.3% |
| BGNE | BeiGene, Ltd.sponsored adr | $1,573,201,000 | -16.7% | 11,668,897 | 0.0% | 10.30% | -3.8% | |
| ACAD | ACADIA Pharmaceuticals Inc. | $685,868,000 | +16.1% | 41,923,486 | 0.0% | 4.49% | +34.0% | |
| BMRN | BioMarin Pharmaceutical Inc. | $645,989,000 | +2.3% | 7,620,494 | 0.0% | 4.23% | +18.1% | |
| ASND | Ascendis Pharma A/Ssponsored adr | $501,085,000 | +11.1% | 4,852,655 | 0.0% | 3.28% | +28.3% | |
| GBT | Global Blood Therapeutics, Inc. | $254,183,000 | +113.1% | 3,732,502 | 0.0% | 1.66% | +145.9% | |
| BCRX | BioCryst Pharmaceuticals, Inc. | $160,156,000 | +19.1% | 12,710,818 | 0.0% | 1.05% | +37.5% | |
| RYTM | Buy | Rhythm Pharmaceuticals, Inc. | $148,536,000 | +767.7% | 6,062,702 | +47.0% | 0.97% | +903.1% |
| KOD | Kodiak Sciences Inc. | $133,983,000 | +1.3% | 17,310,490 | 0.0% | 0.88% | +16.9% | |
| IMCR | Buy | Immunocore Holdings plcads | $118,323,000 | +25.8% | 2,520,731 | +0.0% | 0.78% | +45.1% |
| ABCL | AbCellera Biologics Inc. | $103,352,000 | -7.1% | 10,450,180 | 0.0% | 0.68% | +7.3% | |
| ARGX | Sell | argenx SEsponsored adr | $98,910,000 | -76.7% | 280,159 | -75.0% | 0.65% | -73.1% |
| MRTX | Mirati Therapeutics, Inc. | $98,459,000 | +4.0% | 1,409,784 | 0.0% | 0.64% | +20.1% | |
| MDGL | Madrigal Pharmaceuticals, Inc. | $97,434,000 | -9.2% | 1,499,213 | 0.0% | 0.64% | +4.8% | |
| CCXI | ChemoCentryx, Inc. | $92,609,000 | +108.5% | 1,792,657 | 0.0% | 0.61% | +140.5% | |
| TVTX | Travere Therapeutics, Inc. | $81,312,000 | +1.7% | 3,300,009 | 0.0% | 0.53% | +17.4% | |
| AKRO | Buy | Akero Therapeutics, Inc. | $80,643,000 | +7106.7% | 2,368,378 | +1900.7% | 0.53% | +8700.0% |
| Entrada Therapeutics, Inc. | $76,685,000 | +29.4% | 4,865,819 | 0.0% | 0.50% | +49.4% | ||
| IGMS | IGM Biosciences, Inc. | $71,770,000 | +26.1% | 3,156,102 | 0.0% | 0.47% | +45.5% | |
| REPL | Buy | Replimune Group, Inc. | $67,247,000 | +7.1% | 3,893,843 | +8.4% | 0.44% | +23.6% |
| PRLD | Prelude Therapeutics Inc. | $66,918,000 | +26.6% | 10,123,824 | 0.0% | 0.44% | +46.0% | |
| KYMR | Kymera Therapeutics, Inc. | $62,694,000 | +10.6% | 2,879,825 | 0.0% | 0.41% | +27.6% | |
| HZNP | Sell | Horizon Therapeutics Public Ltd Co | $60,016,000 | -34.5% | 969,727 | -15.6% | 0.39% | -24.4% |
| CERS | Cerus Corporation | $57,843,000 | -31.9% | 16,067,558 | 0.0% | 0.38% | -21.4% | |
| NRIX | Nurix Therapeutics, Inc. | $50,584,000 | +2.8% | 3,882,125 | 0.0% | 0.33% | +18.6% | |
| KDNY | Chinook Therapeutics, Inc. | $49,820,000 | +12.4% | 2,534,102 | 0.0% | 0.33% | +29.9% | |
| VERV | Verve Therapeutics, Inc. | $48,658,000 | +124.8% | 1,416,530 | 0.0% | 0.32% | +159.3% | |
| IMTX | Immatics N.V. | $44,237,000 | +14.8% | 4,423,731 | 0.0% | 0.29% | +32.4% | |
| FMTX | Sell | Forma Therapeutics Holdings, Inc. | $37,641,000 | +169.8% | 1,886,760 | -6.8% | 0.25% | +212.7% |
| Insmed Incorporatednote 0.75% 6/1/2028 | $36,296,000 | +9.1% | 40,000,000 | 0.0% | 0.24% | +25.9% | ||
| KNSA | Kiniksa Pharmaceuticals, Ltd. | $35,947,000 | +32.5% | 2,799,577 | 0.0% | 0.24% | +52.6% | |
| HRTX | Heron Therapeutics, Inc. | $34,316,000 | +51.3% | 8,131,678 | 0.0% | 0.22% | +74.4% | |
| AVTE | Sell | Aerovate Therapeutics, Inc. | $32,821,000 | +1.4% | 1,979,568 | -4.4% | 0.22% | +16.8% |
| 2seventy bio, Inc. | $30,013,000 | +10.2% | 2,062,744 | 0.0% | 0.20% | +27.9% | ||
| KRYS | Sell | Krystal Biotech, Inc. | $29,426,000 | -44.5% | 422,185 | -47.7% | 0.19% | -35.9% |
| XENE | Xenon Pharmaceuticals Inc. | $27,134,000 | +18.7% | 751,639 | 0.0% | 0.18% | +36.9% | |
| New | CinCor Pharma, Inc. | $26,493,000 | – | 807,212 | +100.0% | 0.17% | – | |
| DBVT | DBV Technologies S.A.sponsored adr | $25,867,000 | -30.6% | 14,614,264 | 0.0% | 0.17% | -19.9% | |
| IDYA | New | IDEAYA Biosciences, Inc. | $24,892,000 | – | 1,668,355 | +100.0% | 0.16% | – |
| DSGN | Design Therapeutics, Inc. | $24,021,000 | +19.4% | 1,436,636 | 0.0% | 0.16% | +37.7% | |
| VSTM | Verastem, Inc. | $22,941,000 | -26.7% | 26,988,898 | 0.0% | 0.15% | -15.7% | |
| ALT | Sell | Altimmune, Inc. | $22,599,000 | -6.9% | 1,769,681 | -14.7% | 0.15% | +7.2% |
| BMEA | Biomea Fusion, Inc. | $20,583,000 | -18.4% | 2,104,559 | 0.0% | 0.14% | -5.6% | |
| NVTA | Sell | Invitae Corporation | $20,669,000 | -14.2% | 8,402,035 | -14.9% | 0.14% | -1.5% |
| BCYC | New | Bicycle Therapeutics plcsponsored ads | $19,627,000 | – | 843,814 | +100.0% | 0.13% | – |
| RARE | Ultragenyx Pharmaceutical Inc. | $19,503,000 | -30.6% | 470,974 | 0.0% | 0.13% | -19.5% | |
| TIL | Instil Bio, Inc. | $18,846,000 | +4.8% | 3,893,700 | 0.0% | 0.12% | +20.6% | |
| VERU | New | Veru Inc. | $18,542,000 | – | 1,609,579 | +100.0% | 0.12% | – |
| RLMD | Relmada Therapeutics, Inc. | $18,329,000 | +94.9% | 495,113 | 0.0% | 0.12% | +126.4% | |
| ALKS | Sell | Alkermes plc | $18,199,000 | -59.3% | 815,016 | -45.7% | 0.12% | -53.1% |
| DNLI | Denali Therapeutics Inc. | $18,068,000 | +4.3% | 588,738 | 0.0% | 0.12% | +20.4% | |
| OPT | Sell | Opthea Limitedsponsored ads | $16,687,000 | -1.8% | 2,691,391 | -0.2% | 0.11% | +13.5% |
| BLUE | bluebird bio, Inc. | $15,823,000 | +52.9% | 2,499,715 | 0.0% | 0.10% | +76.3% | |
| CRNX | Sell | Crinetics Pharmaceuticals, Inc. | $14,449,000 | -6.4% | 735,716 | -11.1% | 0.10% | +8.0% |
| New | Aadi Bioscience, Inc. | $13,988,000 | – | 989,928 | +100.0% | 0.09% | – | |
| TCDA | Sell | Tricida, Inc. | $13,837,000 | -4.9% | 1,320,290 | -12.2% | 0.09% | +9.6% |
| AFMD | Affimed N.V. | $13,589,000 | -25.6% | 6,596,830 | 0.0% | 0.09% | -14.4% | |
| DICE Therapeutics, Inc. | $11,929,000 | +30.7% | 588,235 | 0.0% | 0.08% | +50.0% | ||
| ANAB | AnaptysBio, Inc. | $10,897,000 | +25.7% | 427,179 | 0.0% | 0.07% | +44.9% | |
| FGEN | FibroGen, Inc. | $10,612,000 | +23.2% | 815,718 | 0.0% | 0.07% | +40.8% | |
| ZYME | Zymeworks Inc. | $10,507,000 | +16.0% | 1,708,472 | 0.0% | 0.07% | +35.3% | |
| ADAP | Adaptimmune Therapeutics plcsponsored adr | $10,568,000 | -36.8% | 9,830,877 | 0.0% | 0.07% | -27.4% | |
| PNT | New | POINT Biopharma Global Inc. | $9,037,000 | – | 1,169,103 | +100.0% | 0.06% | – |
| TScan Therapeutics, Inc. | $8,494,000 | -3.0% | 2,784,792 | 0.0% | 0.06% | +12.0% | ||
| Invitae Corporationnote 2.0% 9/1/2024 | $8,148,000 | +0.8% | 10,300,000 | 0.0% | 0.05% | +15.2% | ||
| CBAY | CymaBay Therapeutics, Inc. | $7,597,000 | +18.6% | 2,170,464 | 0.0% | 0.05% | +38.9% | |
| VERA | Vera Therapeutics, Inc.cl a | $7,103,000 | +56.6% | 333,333 | 0.0% | 0.05% | +80.8% | |
| PACB | Sell | Pacific Biosciences of California, Inc. | $6,547,000 | -72.8% | 1,127,782 | -79.3% | 0.04% | -68.6% |
| FLGT | Sell | Fulgent Genetics, Inc. | $6,352,000 | -42.2% | 166,619 | -17.3% | 0.04% | -32.3% |
| AMRN | Sell | Amarin Corporation plcsponsored adr | $5,861,000 | -81.4% | 5,377,113 | -74.6% | 0.04% | -78.8% |
| ACHL | Achilles Therapeutics plcsponsored ads | $5,856,000 | -10.3% | 2,591,366 | 0.0% | 0.04% | +2.7% | |
| VOR | Buy | Vor Biopharma Inc. | $5,834,000 | +3.1% | 1,465,925 | +28.7% | 0.04% | +18.8% |
| RETA | Reata Pharmaceuticals, Inc.cl a | $5,629,000 | -17.3% | 223,976 | 0.0% | 0.04% | -5.1% | |
| BCEL | Atreca, Inc. | $5,546,000 | -12.3% | 3,532,760 | 0.0% | 0.04% | 0.0% | |
| KRON | New | Kronos Bio, Inc. | $5,158,000 | – | 1,539,616 | +100.0% | 0.03% | – |
| NKTX | Nkarta, Inc. | $5,264,000 | +6.8% | 400,000 | 0.0% | 0.03% | +21.4% | |
| TLIS | Talis Biomedical Corporation | $5,197,000 | -16.1% | 7,624,835 | 0.0% | 0.03% | -2.9% | |
| CYT | Cyteir Therapeutics, Inc. | $5,076,000 | -35.8% | 2,643,640 | 0.0% | 0.03% | -26.7% | |
| Surrozen, Inc. | $5,050,000 | -32.7% | 2,500,000 | 0.0% | 0.03% | -23.3% | ||
| EWTX | Edgewise Therapeutics, Inc. | $4,920,000 | +23.6% | 500,000 | 0.0% | 0.03% | +39.1% | |
| FATE | New | Fate Therapeutics, Inc. | $4,834,000 | – | 215,695 | +100.0% | 0.03% | – |
| STOK | New | Stoke Therapeutics, Inc. | $4,742,000 | – | 369,327 | +100.0% | 0.03% | – |
| NTRA | Natera, Inc. | $4,382,000 | +23.6% | 100,000 | 0.0% | 0.03% | +45.0% | |
| RVMD | Revolution Medicines, Inc. | $4,382,000 | +1.2% | 222,222 | 0.0% | 0.03% | +16.0% | |
| ALLK | Allakos Inc. | $4,303,000 | +95.5% | 703,050 | 0.0% | 0.03% | +133.3% | |
| EIGR | New | Eiger BioPharmaceuticals, Inc. | $4,065,000 | – | 539,851 | +100.0% | 0.03% | – |
| PMVP | New | PMV Pharmaceuticals, Inc. | $3,832,000 | – | 322,024 | +100.0% | 0.02% | – |
| IPSC | New | Century Therapeutics, Inc. | $3,665,000 | – | 370,587 | +100.0% | 0.02% | – |
| HOOK | HOOKIPA Pharma Inc. | $3,217,000 | -17.8% | 2,400,481 | 0.0% | 0.02% | -4.5% | |
| ATHA | Athira Pharma, Inc. | $3,091,000 | -2.6% | 1,040,834 | 0.0% | 0.02% | +11.1% | |
| MGNX | MacroGenics, Inc. | $3,088,000 | +17.3% | 892,579 | 0.0% | 0.02% | +33.3% | |
| ITOS | iTeos Therapeutics, Inc. | $2,864,000 | -7.5% | 150,346 | 0.0% | 0.02% | +5.6% | |
| ATRA | Atara Biotherapeutics, Inc. | $2,813,000 | -51.5% | 744,186 | 0.0% | 0.02% | -45.5% | |
| Tango Therapeutics, Inc. | $2,715,000 | -20.1% | 750,000 | 0.0% | 0.02% | -5.3% | ||
| SNDX | Syndax Pharmaceuticals, Inc. | $2,661,000 | +24.9% | 110,729 | 0.0% | 0.02% | +41.7% | |
| OTIC | Buy | Otonomy, Inc. | $2,491,000 | -85.8% | 8,443,134 | +0.4% | 0.02% | -83.8% |
| NLTX | Neoleukin Therapeutics, Inc. | $2,446,000 | -37.9% | 3,821,740 | 0.0% | 0.02% | -27.3% | |
| ALGS | Aligos Therapeutics, Inc. | $2,284,000 | -9.1% | 2,076,400 | 0.0% | 0.02% | +7.1% | |
| ALEC | Alector, Inc. | $2,263,000 | -6.9% | 239,228 | 0.0% | 0.02% | +7.1% | |
| AGLE | Aeglea BioTherapeutics, Inc. | $1,794,000 | +4.2% | 3,410,106 | 0.0% | 0.01% | +20.0% | |
| TCRR | TCR2 Therapeutics Inc. | $1,356,000 | -37.9% | 753,064 | 0.0% | 0.01% | -25.0% | |
| LIFE | Sell | aTyr Pharma, Inc. | $604,000 | -43.0% | 201,361 | -46.2% | 0.00% | -33.3% |
| TARA | Protara Therapeutics, Inc. | $591,000 | +1.0% | 199,671 | 0.0% | 0.00% | +33.3% | |
| FHTX | Foghorn Therapeutics Inc. | $386,000 | -36.9% | 45,027 | 0.0% | 0.00% | 0.0% | |
| CABA | Cabaletta Bio, Inc. | $430,000 | -38.7% | 662,063 | 0.0% | 0.00% | -25.0% | |
| INSM | Sell | Insmed Incorporated | $430,000 | -99.0% | 19,950 | -99.1% | 0.00% | -98.8% |
| LPTX | Leap Therapeutics, Inc. | $493,000 | -23.4% | 559,705 | 0.0% | 0.00% | -25.0% | |
| KZR | Kezar Life Sciences, Inc. | $533,000 | +4.1% | 61,946 | 0.0% | 0.00% | 0.0% | |
| GTH | Genetron Holdings Limitedads | $356,000 | -54.0% | 455,306 | 0.0% | 0.00% | -50.0% | |
| Sera Prognostics, Inc. | $322,000 | -2.7% | 201,562 | 0.0% | 0.00% | 0.0% | ||
| VINC | Vincerx Pharma, Inc. | $333,000 | +4.4% | 241,379 | 0.0% | 0.00% | 0.0% | |
| Bellicum Pharmaceuticals, Inc. | $299,000 | +1.0% | 249,123 | 0.0% | 0.00% | 0.0% | ||
| Surrozen, Inc.w exp 8/11/2026 | $154,000 | -3.1% | 833,333 | 0.0% | 0.00% | 0.0% | ||
| LOGC | Sell | LogicBio Therapeutics, Inc. | $38,000 | -75.9% | 139,105 | -69.2% | 0.00% | -100.0% |
| NEXI | Exit | NexImmune, Inc. | $0 | – | -20,000 | -100.0% | 0.00% | – |
| PASG | Exit | Passage Bio, Inc. | $0 | – | -117,161 | -100.0% | -0.00% | – |
| BNR | Exit | Burning Rock Biotech Limitedsponsored ads | $0 | – | -209,131 | -100.0% | -0.00% | – |
| INZY | Exit | Inozyme Pharma, Inc. | $0 | – | -106,999 | -100.0% | -0.00% | – |
| NGM | Exit | NGM Biopharmaceuticals, Inc. | $0 | – | -55,294 | -100.0% | -0.00% | – |
| EPZM | Exit | Epizyme, Inc. | $0 | – | -1,000,000 | -100.0% | -0.01% | – |
| BCAB | Exit | BioAtla, Inc. | $0 | – | -825,000 | -100.0% | -0.01% | – |
| Exit | Evofem Biosciences, Inc. | $0 | – | -2,583,616 | -100.0% | -0.02% | – | |
| CNTA | Exit | Centessa Pharmaceuticals plcsponsored ads | $0 | – | -1,127,273 | -100.0% | -0.03% | – |
| HRMY | Exit | Harmony Biosciences Holdings, Inc. | $0 | – | -123,600 | -100.0% | -0.03% | – |
| KRTX | Exit | Karuna Therapeutics, Inc. | $0 | – | -69,966 | -100.0% | -0.05% | – |
| MRUS | Exit | Merus N.V. | $0 | – | -995,397 | -100.0% | -0.13% | – |
| Exit | Sarepta Therapeutics, Inc.dbcv 1.5% 11/15/2024 | $0 | – | -29,174,000 | -100.0% | -0.21% | – | |
| LEGN | Exit | Legend Biotech Corporationsponsored ads | $0 | – | -856,658 | -100.0% | -0.27% | – |
Original filings
The following EDGAR filing(s) were analyzed to create this report:
- View 13F-HR filed 2022-11-14
About Baker Brothers Advisors
Baker Brothers Advisors is a well-known investment management firm that specializes in the healthcare sector. The firm was founded in 2000 by brothers Julian and Felix Baker, who are both highly respected in the industry. Julian Baker is the CEO of the firm, while Felix Baker serves as a managing partner.
Baker Brothers Advisors has a reputation for investing in innovative healthcare companies that have the potential to make a significant impact on the industry. The firm has a long-term investment approach and is known for taking large positions in companies that it believes in. Some of the firm's most successful investments include companies such as Pharmacyclics, which was acquired by AbbVie for $21 billion, and Ariad Pharmaceuticals, which was acquired by Takeda for $5.2 billion.
The firm's investment strategy is led by its Chief Investment Officer, Dr. Robert Duggan, who has a background in both medicine and finance. Dr. Duggan is known for his ability to identify promising healthcare companies and for his willingness to take risks on early-stage companies.
Overall, Baker Brothers Advisors is a highly respected investment management firm that has a proven track record of success in the healthcare sector. While the firm's investment approach may not be suitable for all investors, those who are interested in the healthcare sector may want to consider Baker Brothers Advisors as a potential investment opportunity.
It's important to note that this information is for educational purposes only and has not been fact-checked. As with any investment, it's important to do your own research and consult with a financial advisor before making any investment decisions.
Top long-term holdings
| Name | Quarters owned | Latest quarter owned | Max weighting |
|---|---|---|---|
| Incyte Corporation | 42 | Q3 2023 | 37.6% |
| ACADIA Pharmaceuticals Inc. | 42 | Q3 2023 | 10.9% |
| Biomarin Pharmaceuticals Inc. | 42 | Q3 2023 | 5.9% |
| BioCryst Pharmaceuticals, Inc. | 42 | Q3 2023 | 1.7% |
| Cerus Corporation | 42 | Q3 2023 | 0.9% |
| Insmed Incorporated | 42 | Q3 2023 | 0.4% |
| Mirati Therapeutics, Inc. | 41 | Q3 2023 | 1.8% |
| Bluebird Bio Inc. | 41 | Q3 2023 | 0.3% |
| Heron Therapeutics, Inc. | 39 | Q3 2023 | 1.5% |
| ChemoCentryx, Inc. | 37 | Q3 2022 | 0.6% |
View Baker Brothers Advisors's complete holdings history.
Latest significant ownerships (13-D/G)
| Filed | Shares | Percentage | |
|---|---|---|---|
| Neoleukin Therapeutics, Inc. | August 17, 2023 | 9,469,838 | 20.0% |
| Mereo Biopharma Group plc | August 10, 2023 | 14,604,391 | 2.2% |
| Verastem, Inc. | August 10, 2023 | ? | ? |
| TScan Therapeutics, Inc. | June 02, 2023 | 2,793,938 | 6.5% |
| ACADIA PHARMACEUTICALS INC | May 24, 2023 | 43,084,280 | 26.5% |
| INCYTE CORP | March 15, 2023 | 36,280,967 | 16.3% |
| Seagen Inc. | March 13, 2023 | 46,985,656 | 25.1% |
| Talis Biomedical Corp | March 10, 2023 | 37,569,140 | 66.2% |
| Aeglea BioTherapeutics, Inc. | February 14, 2023 | 6,384,013 | 9.9% |
| Merus N.V. | February 14, 2023 | ? | ? |
View Baker Brothers Advisors's complete significant-ownership history.
Latest filings
| Type | Filed |
|---|---|
| 4 | 2024-04-23 |
| SC 13D/A | 2024-04-23 |
| 4 | 2024-04-22 |
| 3 | 2024-04-18 |
| SC 13D | 2024-04-18 |
| 3 | 2024-04-01 |
| 4 | 2024-04-01 |
| 4 | 2024-04-01 |
| 4 | 2024-04-01 |
| SC 13D | 2024-04-01 |
View Baker Brothers Advisors's complete filings history.
All filings
- Holdings (13F-HR)
- Significant ownership (13-D/G)
- Insider transactions (4, 5, 6)
- Events (8-K)
- Shareholder votes (proxy)
View complete filings history.