Baker Brothers Advisors Q3 2021 13F Holdings

Baker Brothers Advisors Q3 2021 holdings
TickerName Value Shares↓ Weighting
SGEN Seagen Inc.  $8,029,546
7.6%
47,288,2590.0%35.26%
7.5%
BGNE BeiGene, Ltd.sponsored adr  $4,235,810
5.8%
11,668,8970.0%18.60%
5.8%
INCY Incyte CorporationAdd  $2,202,482
-18.2%
32,022,125
0.0%
9.67%
-18.2%
KOD Kodiak Sciences Inc.Add  $1,409,112
7.2%
14,681,304
3.8%
6.19%
7.2%
ASND Ascendis Pharma A/Ssponsored adrAdd  $723,886
55.4%
4,541,604
28.3%
3.18%
55.5%
ACAD ACADIA Pharmaceuticals...  $696,137
-31.9%
41,910,7040.0%3.06%
-31.9%
BMRN BioMarin Pharmaceutica...Add  $588,988
-7.0%
7,620,494
0.4%
2.59%
-7.0%
ARGX argenx SEsponsored adr  $338,106
0.3%
1,119,5570.0%1.48%
0.3%
PRLD Prelude Therapeutics Inc.  $316,370
9.2%
10,123,8240.0%1.39%
9.1%
NVTA Invitae CorporationReduce  $280,703
-18.8%
9,873,488
-3.7%
1.23%
-18.8%
MRTX Mirati Therapeutics, Inc.  $249,405
9.5%
1,409,7840.0%1.10%
9.5%
ABCL AbCellera Biologics Inc.  $209,422
-8.9%
10,450,1800.0%0.92%
-8.9%
IGMS IGM Biosciences, Inc.  $207,545
-21.0%
3,156,1020.0%0.91%
-21.0%
BCRX BioCryst Pharmaceutica...  $182,654
-9.1%
12,710,8180.0%0.80%
-9.2%
KYMR Kymera Therapeutics, Inc.Add  $140,080
47.4%
2,384,742
21.7%
0.62%
47.5%
PACB Pacific Biosciences of...Add  $139,119
24.2%
5,444,963
70.1%
0.61%
24.2%
MDGL Madrigal Pharmaceutica...  $119,622
-18.1%
1,499,2130.0%0.52%
-18.1%
LEGN Legend Biotech Corpora...sponsored adsAdd  $119,524
74.9%
2,364,003
42.0%
0.52%
75.0%
AMRN Amarin Corporation plcsponsored adrReduce  $111,466
-3.8%
21,856,032
-17.4%
0.49%
-3.9%
IMCR Immunocore Holdings plcads  $93,443
-5.1%
2,520,7300.0%0.41%
-5.1%
HRTX Heron Therapeutics, Inc.  $86,928
-31.1%
8,131,6780.0%0.38%
-31.0%
CERS Cerus Corporation  $83,513
3.0%
13,713,1950.0%0.37%
3.1%
GBT Global Blood Therapeut...  $81,980
-27.2%
3,217,4410.0%0.36%
-27.3%
ALLK Allakos Inc.  $74,432
24.0%
703,0500.0%0.33%
23.9%
NRIX Nurix Therapeutics, Inc.  $73,524
12.9%
2,454,0820.0%0.32%
12.9%
DBVT DBV Technologies S.A.sponsored adr  $71,610
-10.3%
14,614,2640.0%0.31%
-10.3%
TIL Instil Bio, Inc.  $69,600
-7.5%
3,893,7000.0%0.31%
-7.3%
VERV Verve Therapeutics, Inc.  $66,577
-22.0%
1,416,5300.0%0.29%
-22.1%
VSTM Verastem, Inc.  $66,194
-24.3%
21,491,6300.0%0.29%
-24.2%
HZNP Horizon Therapeutics P...  $65,627
17.0%
599,1100.0%0.29%
17.1%
NBIX Neurocrine Biosciences...  $64,929
-1.4%
676,9750.0%0.28%
-1.4%
INSM Insmed Incorporated  $59,376
-3.2%
2,156,0010.0%0.26%
-3.0%
IMTX Immatics N.V.Add  $57,509
15.7%
4,423,731
3.3%
0.25%
16.1%
Apellis Pharmaceutical...note 3.5% 9/15/2026Add  $57,262
106.0%
46,754,000
211.7%
0.25%
105.7%
ADAP Adaptimmune Therapeuti...sponsored adr  $50,826
21.4%
9,830,8770.0%0.22%
21.2%
RYTM Rhythm Pharmaceuticals...  $50,454
-33.3%
3,863,2390.0%0.22%
-33.1%
ZYME Zymeworks Inc.  $49,614
-16.3%
1,708,4720.0%0.22%
-16.2%
TVTX Travere Therapeutics, ...Add  $49,464
1713.9%
2,039,772
991.3%
0.22%
1708.3%
BLUE bluebird bio, Inc.Add  $47,770
558.1%
2,499,715
1001.3%
0.21%
556.2%
TLIS Talis Biomedical Corpo...  $47,343
-43.3%
7,574,8350.0%0.21%
-43.3%
FMTX Forma Therapeutics Hol...  $46,957
-6.8%
2,024,8760.0%0.21%
-6.8%
MRUS Merus N.V.  $44,824
4.4%
2,037,4690.0%0.20%
4.2%
Insmed Incorporatednote 0.75% 6/1/2028  $43,839
-0.5%
40,000,0000.0%0.19%
-0.5%
Sarepta Therapeutics, ...dbcv 1.5% 11/15/2024  $43,167
12.2%
29,174,0000.0%0.19%
12.4%
RARE Ultragenyx Pharmaceuti...  $40,084
-5.4%
444,4440.0%0.18%
-5.4%
ALKS Alkermes plc  $37,877
25.8%
1,228,1700.0%0.17%
25.8%
FLGT Fulgent Genetics, Inc.  $36,071
-2.5%
401,0160.0%0.16%
-2.5%
AVTE Aerovate Therapeutics,...Add  $34,663
6.3%
1,652,171
15.7%
0.15%
6.3%
ALGS Aligos Therapeutics, Inc.Add  $32,205
-1.9%
2,076,400
29.0%
0.14%
-2.1%
KNSA Kiniksa Pharmaceutical...  $31,887
-18.2%
2,799,5770.0%0.14%
-18.1%
KRYS Krystal Biotech, Inc.  $31,730
-23.2%
607,7350.0%0.14%
-23.2%
Tricida, Inc.note 3.5% 5/15/2027  $31,375
14.8%
75,000,0000.0%0.14%
15.0%
NLTX Neoleukin Therapeutics...  $27,631
-21.7%
3,821,7400.0%0.12%
-21.9%
OPT Opthea Limitedsponsored adsReduce  $27,062
-0.1%
3,382,797
-0.9%
0.12%0.0%
AGLE Aeglea BioTherapeutics...  $27,110
14.2%
3,410,1060.0%0.12%
14.4%
KDNY Chinook Therapeutics, ...Add  $24,283
59.2%
1,903,069
76.1%
0.11%
59.7%
BCAB BioAtla, Inc.  $24,288
-30.5%
825,0000.0%0.11%
-30.5%
NVAX Novavax, Inc.Reduce  $22,546
-26.1%
108,756
-24.3%
0.10%
-26.1%
RETA Reata Pharmaceuticals,...cl a  $22,534
-28.9%
223,9760.0%0.10%
-28.8%
BCEL Atreca, Inc.  $22,009
-26.9%
3,532,7600.0%0.10%
-26.5%
DSGN Design Therapeutics, Inc.  $21,104
-26.1%
1,436,6360.0%0.09%
-25.6%
ACHL Achilles Therapeutics plcsponsored ads  $20,187
-20.4%
2,591,3660.0%0.09%
-19.8%
DICE Therapeutics, Inc.New  $19,265588,2350.08%
CRNX Crinetics Pharmaceutic...  $19,380
11.7%
920,6560.0%0.08%
11.8%
CNTA Centessa Pharmaceutica...sponsored adsAdd  $18,825
111.9%
1,127,273
181.8%
0.08%
112.8%
Surrozen, Inc.New  $17,7002,500,0000.08%
AXSM Axsome Therapeutics, Inc.  $17,767
-51.1%
539,0570.0%0.08%
-51.2%
OTIC Otonomy, Inc.Add  $14,773
-8.3%
7,694,038
6.5%
0.06%
-8.5%
CYT Cyteir Therapeutics, Inc.  $14,262
-18.0%
812,6400.0%0.06%
-17.1%
ALBO Albireo Pharma, Inc.  $12,869
-11.3%
412,4660.0%0.06%
-10.9%
MIRM Mirum Pharmaceuticals,...  $12,894
15.2%
647,3130.0%0.06%
16.3%
Invitae Corporationnote 2.0% 9/1/2024  $12,570
-9.5%
10,300,0000.0%0.06%
-9.8%
ALT Altimmune, Inc.  $12,125
14.8%
1,072,0380.0%0.05%
15.2%
Tscan Therapeutics, Inc.New  $11,8851,425,0000.05%
AUPH Aurinia Pharmaceutical...Reduce  $11,519
-20.6%
520,523
-53.5%
0.05%
-20.3%
ANAB AnaptysBio, Inc.  $11,585
4.6%
427,1790.0%0.05%
4.1%
XENE Xenon Pharmaceuticals ...  $11,485
-17.9%
751,6390.0%0.05%
-18.0%
Tango Therapeutics, Inc.New  $9,698750,0000.04%
MGNX MacroGenics, Inc.Add  $9,268
71.9%
442,579
120.5%
0.04%
70.8%
KRTX Karuna Therapeutics, Inc.  $8,559
7.3%
69,9660.0%0.04%
8.6%
EWTX Edgewise Therapeutics,...  $8,300
-22.2%
500,0000.0%0.04%
-23.4%
CABA Cabaletta Bio, Inc.Add  $8,051
47.1%
662,063
4.0%
0.04%
45.8%
CBAY Cymabay Therapeutics, ...  $7,922
-16.3%
2,170,4640.0%0.04%
-16.7%
ATHA Athira Pharma, Inc.  $7,564
-8.4%
806,3670.0%0.03%
-8.3%
BMEA Biomea Fusion, Inc.Add  $6,280
36.8%
524,617
78.4%
0.03%
40.0%
GTH Genetron Holdings Limitedads  $6,306
-31.2%
455,3060.0%0.03%
-30.0%
AMYT Amryt Pharma plcsponsored adrNew  $6,244518,3800.03%
NGM NGM Biopharmaceuticals...  $6,134
6.6%
291,8010.0%0.03%
8.0%
RVMD Revolution Medicines, ...  $6,113
-13.3%
222,2220.0%0.03%
-12.9%
LIFE aTyr Pharma, Inc.New  $5,675625,0000.02%
KURA Kura Oncology, Inc.New  $5,697304,1580.02%
ALEC Alector, Inc.  $5,459
9.6%
239,2280.0%0.02%
9.1%
CCXI ChemoCentryx, Inc.New  $5,150301,1950.02%
RLMD Relmada Therapeutics, ...Add  $5,268
114.8%
200,996
162.4%
0.02%
109.1%
TCDA Tricida, Inc.Add  $4,814
52.8%
1,037,432
42.3%
0.02%
50.0%
HRMY Harmony Biosciences Ho...  $4,738
35.8%
123,6000.0%0.02%
40.0%
BioMarin Pharmaceutica...note 0.599% 8/1/2024Reduce  $4,611
-70.4%
4,500,000
-70.0%
0.02%
-70.6%
DNLI Denali Therapeutics Inc.  $4,477
-35.7%
88,7380.0%0.02%
-35.5%
REPL Replimune Group, Inc.  $4,550
-22.9%
153,5120.0%0.02%
-23.1%
NEXI NexImmune, Inc.  $4,453
-7.2%
294,1170.0%0.02%
-4.8%
ITOS Iteos Therapeutics, Inc.  $4,059
5.3%
150,3460.0%0.02%
5.9%
HOOK HOOKIPA Pharma Inc.  $4,126
-35.7%
700,4810.0%0.02%
-35.7%
XLRN Acceleron Pharma Inc.  $3,860
37.1%
22,4300.0%0.02%
41.7%
VINC Vincerx Pharma, Inc.New  $3,903241,3790.02%
BNR Burning Rock Biotech L...sponsored ads  $3,739
-39.3%
209,1310.0%0.02%
-40.7%
AKRO Akero Therapeutics, Inc.  $2,646
-9.9%
118,3780.0%0.01%
-7.7%
GMDA Gamida Cell Ltd.  $2,394
-38.8%
610,6260.0%0.01%
-35.3%
Sera Prognostics, Inc.New  $2,239201,5620.01%
LPTX Leap Therapeutics, Inc.  $2,244
144.4%
559,7050.0%0.01%
150.0%
EVFM Evofem Biosciences, Inc.  $1,992
-34.6%
2,697,1100.0%0.01%
-30.8%
SNDX Syndax Pharmaceuticals...New  $2,116110,7290.01%
LOGC LogicBio Therapeutics,...  $2,068
3.1%
451,4780.0%0.01%0.0%
TCRR TCR2 Therapeutics Inc.  $1,502
-48.1%
176,4610.0%0.01%
-46.2%
TARA Protara Therapeutics, ...  $1,382
-28.9%
199,6710.0%0.01%
-33.3%
KZR Kezar Life Sciences, Inc.  $1,207
59.2%
139,6760.0%0.01%
66.7%
INZY Inozyme Pharma, Inc.  $1,240
-32.0%
106,9990.0%0.01%
-37.5%
PASG Passage Bio, Inc.  $1,167
-24.8%
117,1610.0%0.01%
-28.6%
Surrozen, Inc.w exp 8/11/2026New  $950833,3330.00%
AFMD Affimed N.V.  $1,017
-27.3%
164,6050.0%0.00%
-33.3%
Bellicum Pharmaceutica...  $727
-11.6%
249,1230.0%0.00%
-25.0%
OYST Oyster Point Pharma, Inc.  $728
-31.1%
61,4240.0%0.00%
-40.0%
MREO Mereo BioPharma Group plcadsReduce  $708
-90.9%
292,692
-88.1%
0.00%
-91.2%
SYRS Syros Pharmaceuticals,...Sold out  $0-65,497-0.00%
FREQ Frequency Therapeutics...Sold out  $0-55,555-0.00%
ORTX Orchard Therapeutics plcadsSold out  $0-1,192,003-0.02%
CHMA Chiasma, Inc.Sold out  $0-1,420,740-0.03%
SBTX Silverback Therapeutic...Sold out  $0-238,095-0.03%
ASMB Assembly Biosciences, ...Sold out  $0-2,108,621-0.04%
ISEE IVERIC bio, Inc.Sold out  $0-1,406,037-0.04%
PTGX Protagonist Therapeuti...Sold out  $0-455,276-0.09%
ADCT ADC Therapeutics SASold out  $0-1,418,107-0.15%
APLS Apellis Pharmaceutical...Sold out  $0-2,271,917-0.63%
  • Baker Brothers Advisors Q3 2021 Portfolio
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  • Quarter
    Q3 2021
  • Total value
    $22.8 Billion
  • Holdings
    122
  • Turnover
    18.3%
  • EDGAR