Baker Brothers Advisors Q2 2021 13F Holdings

Baker Brothers Advisors Q2 2021 holdings
TickerName Value Shares↓ Weighting
SGEN Seagen Inc.Add  $7,465,870
13.7%
47,288,259
0.0%
32.79%
15.2%
BGNE BeiGene, Ltd.sponsored adr  $4,004,649
-1.4%
11,668,8970.0%17.59%
-0.1%
INCY Incyte CorporationAdd  $2,693,988
3.6%
32,021,732
0.1%
11.83%
4.9%
KOD Kodiak Sciences Inc.Add  $1,314,823
-16.5%
14,137,881
1.9%
5.77%
-15.4%
ACAD ACADIA Pharmaceuticals...  $1,022,202
-5.5%
41,910,7040.0%4.49%
-4.2%
BMRN BioMarin Pharmaceutica...  $633,251
10.5%
7,589,2940.0%2.78%
11.9%
ASND Ascendis Pharma A/Ssponsored adr  $465,723
2.1%
3,540,2700.0%2.04%
3.4%
NVTA Invitae CorporationReduce  $345,684
-42.6%
10,248,575
-34.9%
1.52%
-41.8%
ARGX argenx SEsponsored adr  $337,065
9.3%
1,119,5570.0%1.48%
10.7%
PRLD Prelude Therapeutics I...  $289,845
-33.9%
10,123,8240.0%1.27%
-33.1%
IGMS IGM Biosciences, Inc.  $262,588
8.5%
3,156,1020.0%1.15%
9.9%
ABCL AbCellera Biologics Inc.  $229,904
-35.2%
10,450,1800.0%1.01%
-34.4%
MRTX Mirati Therapeutics, Inc.  $227,722
-5.7%
1,409,7840.0%1.00%
-4.5%
BCRX BioCryst Pharmaceutica...  $200,958
55.5%
12,710,8180.0%0.88%
57.7%
MDGL Madrigal Pharmaceutica...  $146,038
-16.7%
1,499,2130.0%0.64%
-15.7%
APLS Apellis Pharmaceutical...Add  $143,585
99.9%
2,271,917
35.7%
0.63%
102.9%
HRTX Heron Therapeutics, Inc.Add  $126,204
29.9%
8,131,678
35.6%
0.55%
31.6%
AMRN Amarin Corporation plcsponsored adr  $115,866
-29.5%
26,453,4220.0%0.51%
-28.5%
GBT Global Blood Therapeut...  $112,675
-14.1%
3,217,4410.0%0.50%
-12.9%
PACB Pacific Biosciences of...  $111,973
5.0%
3,201,9720.0%0.49%
6.5%
IMCR Immunocore Holdings plcads  $98,435
-8.3%
2,520,7300.0%0.43%
-7.1%
KYMR Kymera Therapeutics, Inc.  $95,022
24.8%
1,959,2110.0%0.42%
26.4%
VSTM Verastem, Inc.Add  $87,471
108.1%
21,491,630
26.3%
0.38%
111.0%
VERV Verve Therapeutics, Inc.New  $85,3461,416,5300.38%
TLIS Talis Biomedical Corpo...  $83,550
-14.2%
7,574,8350.0%0.37%
-13.0%
CERS Cerus Corporation  $81,045
-1.7%
13,713,1950.0%0.36%
-0.3%
DBVT DBV Technologies S.A.sponsored adr  $79,794
2.4%
14,614,2640.0%0.35%
3.6%
RYTM Rhythm Pharmaceuticals...Add  $75,642
2.2%
3,863,239
11.0%
0.33%
3.4%
TIL Instil Bio, Inc.  $75,226
-23.0%
3,893,7000.0%0.33%
-22.0%
LEGN Legend Biotech Corpora...sponsored adsAdd  $68,329
1936.6%
1,664,534
1339.6%
0.30%
1900.0%
NBIX Neurocrine Biosciences...  $65,883
0.1%
676,9750.0%0.29%
1.4%
NRIX Nurix Therapeutics, Inc.  $65,107
-14.7%
2,454,0820.0%0.29%
-13.6%
INSM Insmed Incorporated  $61,360
-16.4%
2,156,0010.0%0.27%
-15.4%
ALLK Allakos Inc.  $60,019
-25.6%
703,0500.0%0.26%
-24.6%
ZYME Zymeworks Inc.  $59,267
9.8%
1,708,4720.0%0.26%
11.1%
HZNP Horizon Therapeutics P...  $56,101
1.7%
599,1100.0%0.25%
2.9%
FMTX Forma Therapeutics Hol...  $50,399
-11.2%
2,024,8760.0%0.22%
-10.2%
IMTX Immatics N.V.Add  $49,725
11.1%
4,282,938
7.3%
0.22%
12.4%
Insmed Incorporatednote 0.75% 6/1/2028New  $44,06340,000,0000.19%
MRUS Merus N.V.  $42,929
0.9%
2,037,4690.0%0.19%
2.2%
RARE Ultragenyx Pharmaceuti...  $42,378
-16.3%
444,4440.0%0.19%
-15.1%
ADAP Adaptimmune Therapeuti...sponsored adr  $41,880
-19.8%
9,830,8770.0%0.18%
-18.6%
KRYS Krystal Biotech, Inc.Reduce  $41,326
-29.5%
607,735
-20.1%
0.18%
-28.7%
KNSA Kiniksa Pharmaceutical...  $38,998
-24.7%
2,799,5770.0%0.17%
-24.0%
Sarepta Therapeutics, ...dbcv 1.5% 11/15/2024Add  $38,479
221.5%
29,174,000
218.0%
0.17%
225.0%
FLGT Fulgent Genetics, Inc.  $36,986
-4.5%
401,0160.0%0.16%
-3.6%
AXSM Axsome Therapeutics, Inc.Reduce  $36,365
2.2%
539,057
-14.2%
0.16%
3.9%
NLTX Neoleukin Therapeutics...  $35,275
-25.0%
3,821,7400.0%0.16%
-24.0%
BCAB BioAtla, Inc.  $34,964
-16.6%
825,0000.0%0.15%
-15.4%
ADCT ADC Therapeutics SA  $34,531
-0.2%
1,418,1070.0%0.15%
1.3%
ALGS Aligos Therapeutics, Inc.  $32,820
-10.4%
1,610,0000.0%0.14%
-9.4%
AVTE Aerovate Therapeutics,...New  $32,6141,428,5710.14%
RETA Reata Pharmaceuticals,...cl a  $31,699
42.0%
223,9760.0%0.14%
43.3%
NVAX Novavax, Inc.  $30,521
17.1%
143,7560.0%0.13%
18.6%
BCEL Atreca, Inc.  $30,099
-44.4%
3,532,7600.0%0.13%
-43.8%
ALKS Alkermes plc  $30,115
31.3%
1,228,1700.0%0.13%
33.3%
DSGN Design Therapeutics, Inc.  $28,575
-33.5%
1,436,6360.0%0.12%
-32.8%
Apellis Pharmaceutical...note 3.5% 9/15/2026New  $27,79315,000,0000.12%
Tricida, Inc.note 3.5% 5/15/2027New  $27,33275,000,0000.12%
OPT Opthea Limitedsponsored adsAdd  $27,092
-14.4%
3,412,062
3.1%
0.12%
-13.1%
ACHL Achilles Therapeutics plcsponsored ads  $25,369
-40.8%
2,591,3660.0%0.11%
-40.3%
AGLE Aeglea BioTherapeutics...  $23,734
-12.1%
3,410,1060.0%0.10%
-11.1%
PTGX Protagonist Therapeuti...Reduce  $20,433
-45.1%
455,276
-68.3%
0.09%
-44.1%
CYT Cyteir Therapeutics, Inc.New  $17,390812,6400.08%
CRNX Crinetics Pharmaceutic...Add  $17,354
84.2%
920,656
49.3%
0.08%
85.4%
OTIC Otonomy, Inc.Add  $16,106
-12.5%
7,222,474
0.0%
0.07%
-11.2%
BioMarin Pharmaceutica...note 0.599% 8/1/2024  $15,566
1.7%
15,000,0000.0%0.07%
3.0%
KDNY Chinook Therapeutics, ...Add  $15,255
31.1%
1,080,393
44.3%
0.07%
34.0%
AUPH Aurinia Pharmaceutical...Reduce  $14,515
-20.7%
1,119,962
-20.6%
0.06%
-19.0%
ALBO Albireo Pharma, Inc.  $14,511
-0.2%
412,4660.0%0.06%
1.6%
Invitae Corporationnote 2.0% 9/1/2024  $13,890
-10.7%
10,300,0000.0%0.06%
-9.0%
XENE Xenon Pharmaceuticals ...  $13,996
4.0%
751,6390.0%0.06%
5.2%
ANAB AnaptysBio, Inc.  $11,077
20.3%
427,1790.0%0.05%
22.5%
MIRM Mirum Pharmaceuticals,...  $11,192
-12.8%
647,3130.0%0.05%
-12.5%
EWTX Edgewise Therapeutics,...  $10,665
-34.4%
500,0000.0%0.05%
-32.9%
ALT Altimmune, Inc.Reduce  $10,560
-72.9%
1,072,038
-61.1%
0.05%
-72.8%
CBAY Cymabay Therapeutics, ...  $9,463
-4.0%
2,170,4640.0%0.04%
-2.3%
GTH Genetron Holdings Limitedads  $9,170
-6.2%
455,3060.0%0.04%
-4.8%
ISEE IVERIC bio, Inc.  $8,872
2.1%
1,406,0370.0%0.04%
2.6%
CNTA Centessa Pharmaceutica...sponsored adsNew  $8,884400,0000.04%
ATHA Athira Pharma, Inc.  $8,257
-44.3%
806,3670.0%0.04%
-43.8%
ASMB Assembly Biosciences, ...Add  $8,181
15.4%
2,108,621
36.8%
0.04%
16.1%
KRTX Karuna Therapeutics, Inc.  $7,975
-5.2%
69,9660.0%0.04%
-2.8%
MREO Mereo BioPharma Group plcadsReduce  $7,796
-65.6%
2,459,399
-63.4%
0.03%
-65.3%
BLUE bluebird bio, Inc.  $7,259
6.1%
226,9880.0%0.03%
6.7%
SBTX Silverback Therapeutic...  $7,355
-29.2%
238,0950.0%0.03%
-28.9%
DNLI Denali Therapeutics Inc.  $6,961
37.4%
88,7380.0%0.03%
40.9%
RVMD Revolution Medicines, ...  $7,053
-30.8%
222,2220.0%0.03%
-29.5%
CHMA Chiasma, Inc.Add  $6,720
189.3%
1,420,740
91.4%
0.03%
200.0%
HOOK HOOKIPA Pharma Inc.  $6,416
-31.9%
700,4810.0%0.03%
-31.7%
BNR Burning Rock Biotech L...sponsored ads  $6,161
9.4%
209,1310.0%0.03%
12.5%
REPL Replimune Group, Inc.  $5,898
25.9%
153,5120.0%0.03%
30.0%
NGM NGM Biopharmaceuticals...  $5,754
-32.2%
291,8010.0%0.02%
-32.4%
CABA Cabaletta Bio, Inc.  $5,473
-22.5%
636,3630.0%0.02%
-22.6%
MGNX MacroGenics, Inc.  $5,390
-15.7%
200,6790.0%0.02%
-14.3%
ORTX Orchard Therapeutics plcadsAdd  $5,233
-1.9%
1,192,003
62.3%
0.02%0.0%
ALEC Alector, Inc.  $4,983
3.4%
239,2280.0%0.02%
4.8%
NEXI NexImmune, Inc.  $4,800
-14.5%
294,1170.0%0.02%
-12.5%
BMEA Biomea Fusion, Inc.New  $4,591294,1170.02%
ITOS Iteos Therapeutics, Inc.  $3,856
-25.0%
150,3460.0%0.02%
-22.7%
GMDA Gamida Cell Ltd.Reduce  $3,914
-53.4%
610,626
-41.1%
0.02%
-52.8%
HRMY Harmony Biosciences Ho...  $3,489
-14.6%
123,6000.0%0.02%
-16.7%
TCDA Tricida, Inc.  $3,151
-18.3%
729,3000.0%0.01%
-17.6%
AKRO Akero Therapeutics, Inc.  $2,937
-14.5%
118,3780.0%0.01%
-13.3%
TCRR TCR2 Therapeutics Inc.  $2,896
-25.7%
176,4610.0%0.01%
-23.5%
EVFM Evofem Biosciences, Inc.  $3,048
-35.4%
2,697,1100.0%0.01%
-35.0%
TVTX Travere Therapeutics, ...  $2,727
-41.6%
186,9150.0%0.01%
-40.0%
XLRN Acceleron Pharma Inc.  $2,815
-7.5%
22,4300.0%0.01%
-7.7%
RLMD Relmada Therapeutics, ...New  $2,45276,6000.01%
TARA Protara Therapeutics, ...  $1,945
-38.1%
199,6710.0%0.01%
-35.7%
LOGC LogicBio Therapeutics,...  $2,005
-39.0%
451,4780.0%0.01%
-35.7%
INZY Inozyme Pharma, Inc.  $1,823
-14.0%
106,9990.0%0.01%
-11.1%
PASG Passage Bio, Inc.Reduce  $1,551
-62.3%
117,161
-50.2%
0.01%
-61.1%
AFMD Affimed N.V.  $1,399
7.5%
164,6050.0%0.01%0.0%
OYST Oyster Point Pharma, Inc.  $1,056
-6.0%
61,4240.0%0.01%0.0%
Bellicum Pharmaceutica...  $822
-12.3%
249,1230.0%0.00%0.0%
LPTX Leap Therapeutics, Inc.  $918
-13.6%
559,7050.0%0.00%
-20.0%
KZR Kezar Life Sciences, Inc.  $758
-8.9%
139,6760.0%0.00%
-25.0%
SYRS Syros Pharmaceuticals,...Reduce  $357
-93.1%
65,497
-90.5%
0.00%
-90.9%
FREQ Frequency Therapeutics...  $553
4.7%
55,5550.0%0.00%0.0%
GNFT Genfit SAadsSold out  $0-14,7200.00%
IFRX Inflarx N.V.Sold out  $0-138,040-0.00%
ADMS Adamas Pharmaceuticals...Sold out  $0-147,996-0.00%
GLMD Galmed Pharmaceuticals...Sold out  $0-184,927-0.00%
GLPG Galapagos NVsponsored adrSold out  $0-11,180-0.00%
MTEM Molecular Templates, Inc.Sold out  $0-133,833-0.01%
VKTX Viking Therapeutics, Inc.Sold out  $0-363,980-0.01%
AUTL Autolus Therapeutics plcsponsored adsSold out  $0-461,726-0.01%
IDRA Idera Pharmaceuticals,...Sold out  $0-2,047,180-0.01%
CNST Constellation Pharmace...Sold out  $0-114,735-0.01%
SRPT Sarepta Therapeutics, ...Sold out  $0-58,700-0.02%
SGMO Sangamo Therapeutics, ...Sold out  $0-429,063-0.02%
XNCR Xencor, Inc.Sold out  $0-369,370-0.07%
CCXI ChemoCentryx, Inc.Sold out  $0-656,710-0.15%
ALXN Alexion Pharmaceutical...Sold out  $0-3,993,312-2.65%
  • Baker Brothers Advisors Q2 2021 Portfolio
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  • Quarter
    Q2 2021
  • Total value
    $22.8 Billion
  • Holdings
    120
  • Turnover
    19.0%
  • EDGAR