Baker Brothers Advisors Q1 2021 13F Holdings

Baker Brothers Advisors Q1 2021 holdings
TickerName Value Shares↓ Weighting
SGEN Seagen Inc.Add  $6,564,018
-20.7%
47,270,759
0.0%
28.46%
-8.8%
BGNE BeiGene, Ltd.sponsored adr  $4,061,710
34.7%
11,668,8970.0%17.61%
55.0%
INCY Incyte CorporationAdd  $2,600,753
-6.6%
32,001,387
0.0%
11.28%
7.5%
KOD Kodiak Sciences Inc.  $1,573,848
-22.8%
13,879,9520.0%6.82%
-11.2%
ACAD ACADIA Pharmaceuticals...Add  $1,081,296
-51.7%
41,910,704
0.0%
4.69%
-44.5%
ALXN Alexion Pharmaceutical...Reduce  $610,617
-55.4%
3,993,312
-54.4%
2.65%
-48.7%
NVTA Invitae CorporationAdd  $601,776
-8.0%
15,749,182
0.6%
2.61%
5.8%
BMRN BioMarin Pharmaceutica...  $573,068
-13.9%
7,589,2940.0%2.48%
-0.9%
ASND Ascendis Pharma A/Ssponsored adr  $456,270
-22.7%
3,540,2700.0%1.98%
-11.1%
PRLD Prelude Therapeutics I...Add  $438,665
-39.4%
10,123,824
0.1%
1.90%
-30.3%
ABCL AbCellera Biologics Inc.  $354,888
-15.6%
10,450,1800.0%1.54%
-2.8%
ARGX argenx SEsponsored adrAdd  $308,315
2.8%
1,119,557
9.8%
1.34%
18.3%
IGMS IGM Biosciences, Inc.Add  $242,041
-12.8%
3,156,102
0.4%
1.05%
0.3%
MRTX Mirati Therapeutics, Inc.  $241,496
-22.0%
1,409,7840.0%1.05%
-10.3%
MDGL Madrigal Pharmaceutica...  $175,363
5.2%
1,499,2130.0%0.76%
21.0%
AMRN Amarin Corporation plcsponsored adrReduce  $164,276
20.0%
26,453,422
-5.5%
0.71%
38.0%
GBT Global Blood Therapeut...Add  $131,111
228.9%
3,217,441
249.6%
0.57%
278.7%
BCRX BioCryst Pharmaceutica...Add  $129,269
36.7%
12,710,818
0.1%
0.56%
57.3%
IMCR Immunocore Holdings plcadsNew  $107,3072,520,7300.46%
PACB Pacific Biosciences of...  $106,658
28.4%
3,201,9720.0%0.46%
47.6%
Instil Bio, Inc.New  $97,6543,893,7000.42%
TLIS Talis Biomedical Corpo...New  $97,3377,574,8350.42%
HRTX Heron Therapeutics, Inc.  $97,174
-23.4%
5,994,7040.0%0.42%
-11.9%
CERS Cerus Corporation  $82,416
-13.2%
13,713,1950.0%0.36%
-0.3%
ALLK Allakos Inc.Reduce  $80,696
-19.3%
703,050
-1.6%
0.35%
-7.2%
DBVT DBV Technologies S.A.sponsored adr  $77,894
103.4%
14,614,2640.0%0.34%
134.7%
NRIX Nurix Therapeutics, Inc.Add  $76,297
29.7%
2,454,082
37.2%
0.33%
49.1%
KYMR Kymera Therapeutics, Inc.  $76,135
-37.3%
1,959,2110.0%0.33%
-27.9%
RYTM Rhythm Pharmaceuticals...Add  $74,017
7.6%
3,479,873
50.3%
0.32%
23.9%
INSM Insmed Incorporated  $73,433
2.3%
2,156,0010.0%0.32%
17.8%
APLS Apellis Pharmaceutical...Add  $71,832
40.1%
1,674,004
86.7%
0.31%
61.1%
NBIX Neurocrine Biosciences...  $65,836
1.5%
676,9750.0%0.28%
16.8%
KRYS Krystal Biotech, Inc.Add  $58,582
39.7%
760,412
8.8%
0.25%
60.8%
FMTX Forma Therapeutics Hol...  $56,737
-19.7%
2,024,8760.0%0.25%
-7.5%
HZNP Horizon Therapeutics P...  $55,142
25.8%
599,1100.0%0.24%
44.8%
BCEL Atreca, Inc.  $54,157
-5.1%
3,532,7600.0%0.24%
9.3%
ZYME Zymeworks Inc.  $53,954
-33.2%
1,708,4720.0%0.23%
-23.0%
ADAP Adaptimmune Therapeuti...sponsored adr  $52,202
-1.5%
9,830,8770.0%0.23%
13.0%
KNSA Kiniksa Pharmaceutical...  $51,820
4.8%
2,799,5770.0%0.22%
21.0%
RARE Ultragenyx Pharmaceuti...  $50,604
-17.7%
444,4440.0%0.22%
-5.6%
NLTX Neoleukin Therapeutics...  $47,046
-12.7%
3,821,7400.0%0.20%
0.5%
IMTX Immatics N.V.Add  $44,759
129.8%
3,992,756
121.2%
0.19%
165.8%
Achilles Therapeutics plcsponsored adsNew  $42,8872,591,3660.19%
Design Therapeutics, Inc.New  $42,9551,436,6360.19%
MRUS Merus N.V.  $42,563
19.2%
2,037,4690.0%0.18%
37.0%
VSTM Verastem, Inc.Add  $42,038
94.6%
17,019,294
67.8%
0.18%
124.7%
BCAB BioAtla, Inc.  $41,943
49.5%
825,0000.0%0.18%
71.7%
ALT Altimmune, Inc.Add  $38,978
83.4%
2,758,518
46.4%
0.17%
111.2%
FLGT Fulgent Genetics, Inc.Reduce  $38,746
50.1%
401,016
-19.1%
0.17%
73.2%
PTGX Protagonist Therapeuti...  $37,197
28.5%
1,436,1920.0%0.16%
47.7%
ALGS Aligos Therapeutics, Inc.  $36,611
-17.8%
1,610,0000.0%0.16%
-5.4%
AXSM Axsome Therapeutics, Inc.Reduce  $35,581
-43.9%
628,414
-19.3%
0.15%
-35.6%
ADCT ADC Therapeutics SA  $34,616
-23.7%
1,418,1070.0%0.15%
-12.3%
CCXI ChemoCentryx, Inc.  $33,650
-17.2%
656,7100.0%0.15%
-4.6%
OPT Opthea Limitedsponsored ads  $31,664
-14.7%
3,308,7050.0%0.14%
-2.1%
AGLE Aeglea BioTherapeutics...  $27,008
0.6%
3,410,1060.0%0.12%
15.8%
NVAX Novavax, Inc.Reduce  $26,064
37.7%
143,756
-15.3%
0.11%
59.2%
ALKS Alkermes plcReduce  $22,942
-25.1%
1,228,170
-20.0%
0.10%
-13.9%
MREO Mereo BioPharma Group plcadsAdd  $22,646
4.9%
6,719,948
11.4%
0.10%
21.0%
RETA Reata Pharmaceuticals,...cl a  $22,330
-19.4%
223,9760.0%0.10%
-6.7%
OTIC Otonomy, Inc.New  $18,4117,220,0740.08%
AUPH Aurinia Pharmaceutical...  $18,310
-6.1%
1,410,0640.0%0.08%
8.2%
Edgewise Therapeutics,...New  $16,250500,0000.07%
XNCR Xencor, Inc.  $15,905
-1.3%
369,3700.0%0.07%
13.1%
Invitae Corporationnote 2.0% 9/1/2024  $15,557
-5.4%
10,300,0000.0%0.07%
8.1%
BioMarin Pharmaceutica...note 0.599% 8/1/2024  $15,299
-4.6%
15,000,0000.0%0.07%
10.0%
ATHA Athira Pharma, Inc.  $14,837
-46.3%
806,3670.0%0.06%
-38.5%
ALBO Albireo Pharma, Inc.  $14,539
-6.0%
412,4660.0%0.06%
8.6%
XENE Xenon Pharmaceuticals ...Add  $13,454
27.3%
751,639
9.3%
0.06%
45.0%
MIRM Mirum Pharmaceuticals,...  $12,830
13.5%
647,3130.0%0.06%
30.2%
Sarepta Therapeutics, ...dbcv 1.5% 11/15/2024New  $11,9709,174,0000.05%
KDNY Chinook Therapeutics, ...  $11,635
-2.0%
748,6930.0%0.05%
11.1%
SBTX Silverback Therapeutic...  $10,388
-5.8%
238,0950.0%0.04%
7.1%
RVMD Revolution Medicines, ...New  $10,196222,2220.04%
CBAY Cymabay Therapeutics, ...Reduce  $9,854
-40.7%
2,170,464
-25.0%
0.04%
-31.7%
GTH Genetron Holdings Limitedads  $9,771
53.3%
455,3060.0%0.04%
75.0%
HOOK HOOKIPA Pharma Inc.  $9,421
21.3%
700,4810.0%0.04%
41.4%
CRNX Crinetics Pharmaceutic...  $9,420
8.3%
616,5200.0%0.04%
24.2%
ANAB AnaptysBio, Inc.  $9,206
0.2%
427,1790.0%0.04%
14.3%
ISEE IVERIC bio, Inc.  $8,689
-10.6%
1,406,0370.0%0.04%
2.7%
NGM NGM Biopharmaceuticals...Add  $8,483
162.6%
291,801
173.7%
0.04%
208.3%
GMDA Gamida Cell Ltd.Reduce  $8,391
-35.4%
1,037,226
-33.0%
0.04%
-26.5%
KRTX Karuna Therapeutics, Inc.  $8,412
18.3%
69,9660.0%0.04%
33.3%
ASMB Assembly Biosciences, ...  $7,091
-24.0%
1,541,4180.0%0.03%
-11.4%
CABA Cabaletta Bio, Inc.  $7,064
-11.1%
636,3630.0%0.03%
3.3%
BLUE bluebird bio, Inc.  $6,844
-30.3%
226,9880.0%0.03%
-18.9%
MGNX MacroGenics, Inc.  $6,392
39.3%
200,6790.0%0.03%
64.7%
BNR Burning Rock Biotech L...sponsored ads  $5,630
16.5%
209,1310.0%0.02%
33.3%
NEXI NexImmune, Inc.New  $5,612294,1170.02%
ORTX Orchard Therapeutics plcadsAdd  $5,332
271.3%
734,431
120.9%
0.02%
360.0%
SGMO Sangamo Therapeutics, ...Reduce  $5,376
-59.8%
429,063
-50.0%
0.02%
-54.0%
SYRS Syros Pharmaceuticals,...  $5,162
-31.1%
690,1670.0%0.02%
-21.4%
ITOS Iteos Therapeutics, Inc.  $5,139
1.1%
150,3460.0%0.02%
15.8%
DNLI Denali Therapeutics Inc.  $5,067
-31.8%
88,7380.0%0.02%
-21.4%
ALEC Alector, Inc.  $4,818
33.1%
239,2280.0%0.02%
50.0%
EVFM Evofem Biosciences, Inc.Add  $4,720
376.3%
2,697,110
555.6%
0.02%
400.0%
REPL Replimune Group, Inc.  $4,684
-20.0%
153,5120.0%0.02%
-9.1%
TVTX Travere Therapeutics, ...New  $4,667186,9150.02%
SRPT Sarepta Therapeutics, ...New  $4,37558,7000.02%
PASG Passage Bio, Inc.  $4,114
-31.6%
235,3620.0%0.02%
-21.7%
HRMY Harmony Biosciences Ho...Reduce  $4,084
-37.2%
123,600
-31.3%
0.02%
-28.0%
TCDA Tricida, Inc.Add  $3,858
-13.0%
729,300
15.9%
0.02%0.0%
TCRR TCR2 Therapeutics Inc.Add  $3,896
13.6%
176,461
59.1%
0.02%
30.8%
AKRO Akero Therapeutics, Inc.  $3,434
12.4%
118,3780.0%0.02%
25.0%
LEGN Legend Biotech Corpora...sponsored ads  $3,355
3.0%
115,6260.0%0.02%
25.0%
LOGC LogicBio Therapeutics,...  $3,287
-4.6%
451,4780.0%0.01%
7.7%
TARA Protara Therapeutics, ...  $3,143
-35.0%
199,6710.0%0.01%
-22.2%
XLRN Acceleron Pharma Inc.  $3,042
6.0%
22,4300.0%0.01%
18.2%
CNST Constellation Pharmace...  $2,684
-18.8%
114,7350.0%0.01%0.0%
IDRA Idera Pharmaceuticals,...Reduce  $2,661
-84.3%
2,047,180
-55.6%
0.01%
-81.2%
AUTL Autolus Therapeutics plcsponsored adsReduce  $2,646
-62.2%
461,726
-41.0%
0.01%
-57.7%
VKTX Viking Therapeutics, Inc.  $2,302
12.3%
363,9800.0%0.01%
25.0%
CHMA Chiasma, Inc.  $2,323
-28.0%
742,1330.0%0.01%
-16.7%
INZY Inozyme Pharma, Inc.  $2,119
-4.0%
106,9990.0%0.01%
12.5%
MTEM Molecular Templates, Inc.  $1,689
34.4%
133,8330.0%0.01%
40.0%
Affimed N.V.  $1,302
35.9%
164,6050.0%0.01%
50.0%
LPTX Leap Therapeutics, Inc.  $1,063
-15.6%
559,7050.0%0.01%0.0%
OYST Oyster Point Pharma, Inc.  $1,123
-2.9%
61,4240.0%0.01%
25.0%
Bellicum Pharmaceutica...  $937
6.6%
249,1230.0%0.00%
33.3%
KZR Kezar Life Sciences, Inc.  $832
14.1%
139,6760.0%0.00%
33.3%
GLPG Galapagos NVsponsored adr  $862
-22.1%
11,1800.0%0.00%0.0%
ADMS Adamas Pharmaceuticals...  $710
10.8%
147,9960.0%0.00%
50.0%
GLMD Galmed Pharmaceuticals...  $634
10.3%
184,9270.0%0.00%
50.0%
FREQ Frequency Therapeutics...Reduce  $528
-98.3%
55,555
-93.5%
0.00%
-98.2%
IFRX Inflarx N.V.Reduce  $538
-87.5%
138,040
-83.9%
0.00%
-87.5%
GNFT Genfit SAads  $68
-4.2%
14,7200.0%0.00%
SNSS Sunesis Pharmaceutical...Sold out  $0-53,0660.00%
QURE uniQure N.V.Sold out  $0-6,740-0.00%
INFI Infinity Pharmaceutica...Sold out  $0-522,360-0.00%
RCUS Arcus Biosciences, Inc.Sold out  $0-72,709-0.01%
DRNA Dicerna Pharmaceutical...Sold out  $0-102,121-0.01%
OVID Ovid Therapeutics Inc.Sold out  $0-955,690-0.01%
GOSS Gossamer Bio, Inc.Sold out  $0-480,729-0.02%
NTLA Intellia Therapeutics,...Sold out  $0-111,296-0.02%
VXRT Vaxart, Inc.Sold out  $0-1,398,795-0.03%
FPRX Five Prime Therapeutic...Sold out  $0-668,000-0.04%
GWPH GW Pharmaceuticals plcadsSold out  $0-112,897-0.05%
ADPT Adaptive Biotechnologi...Sold out  $0-379,682-0.08%