Name,Ticker,Title of class,Class,Change,CUSIP,Value,Shares or principal amount,Weighting Seagen Inc.,SGEN,, ,81181C104,6419005000.0,46912266.0,42.038 Incyte Corporation,INCY,,Buy,45337C102,2409341000.0,36154574.0,15.779 "BeiGene, Ltd.",BGNE,sponsored adr, ,07725L102,1573201000.0,11668897.0,10.303 ACADIA Pharmaceuticals Inc.,ACAD,, ,004225108,685868000.0,41923486.0,4.492 BioMarin Pharmaceutical Inc.,BMRN,, ,09061G101,645989000.0,7620494.0,4.231 Ascendis Pharma A/S,ASND,sponsored adr, ,04351P101,501085000.0,4852655.0,3.282 "Global Blood Therapeutics, Inc.",GBT,, ,37890U108,254183000.0,3732502.0,1.665 "BioCryst Pharmaceuticals, Inc.",BCRX,, ,09058V103,160156000.0,12710818.0,1.049 "Rhythm Pharmaceuticals, Inc.",RYTM,,Buy,76243J105,148536000.0,6062702.0,0.973 Kodiak Sciences Inc.,KOD,, ,50015M109,133983000.0,17310490.0,0.877 Immunocore Holdings plc,IMCR,ads,Buy,45258D105,118323000.0,2520731.0,0.775 AbCellera Biologics Inc.,ABCL,, ,00288U106,103352000.0,10450180.0,0.677 argenx SE,ARGX,sponsored adr,Sell,04016X101,98910000.0,280159.0,0.648 "Mirati Therapeutics, Inc.",MRTX,, ,60468T105,98459000.0,1409784.0,0.645 "Madrigal Pharmaceuticals, Inc.",MDGL,, ,558868105,97434000.0,1499213.0,0.638 "ChemoCentryx, Inc.",CCXI,, ,16383L106,92609000.0,1792657.0,0.606 "Travere Therapeutics, Inc.",TVTX,, ,89422G107,81312000.0,3300009.0,0.533 "Akero Therapeutics, Inc.",AKRO,,Buy,00973Y108,80643000.0,2368378.0,0.528 "Entrada Therapeutics, Inc.",,, ,29384C108,76685000.0,4865819.0,0.502 "IGM Biosciences, Inc.",IGMS,, ,449585108,71770000.0,3156102.0,0.47 "Replimune Group, Inc.",REPL,,Buy,76029N106,67247000.0,3893843.0,0.44 Prelude Therapeutics Inc.,PRLD,, ,74065P101,66918000.0,10123824.0,0.438 "Kymera Therapeutics, Inc.",KYMR,, ,501575104,62694000.0,2879825.0,0.411 Horizon Therapeutics Public Ltd Co,HZNP,,Sell,G46188101,60016000.0,969727.0,0.393 Cerus Corporation,CERS,, ,157085101,57843000.0,16067558.0,0.379 "Nurix Therapeutics, Inc.",NRIX,, ,67080M103,50584000.0,3882125.0,0.331 "Chinook Therapeutics, Inc.",KDNY,, ,16961L106,49820000.0,2534102.0,0.326 "Verve Therapeutics, Inc.",VERV,, ,92539P101,48658000.0,1416530.0,0.319 Immatics N.V.,IMTX,, ,N44445109,44237000.0,4423731.0,0.29 "Forma Therapeutics Holdings, Inc.",FMTX,,Sell,34633R104,37641000.0,1886760.0,0.247 Insmed Incorporated,,note 0.75% 6/1/2028, ,457669AB5,36296000.0,40000000.0,0.238 "Kiniksa Pharmaceuticals, Ltd.",KNSA,, ,G5269C101,35947000.0,2799577.0,0.235 "Heron Therapeutics, Inc.",HRTX,, ,427746102,34316000.0,8131678.0,0.225 "Aerovate Therapeutics, Inc.",AVTE,,Sell,008064107,32821000.0,1979568.0,0.215 "2seventy bio, Inc.",,, ,901384107,30013000.0,2062744.0,0.197 "Krystal Biotech, Inc.",KRYS,,Sell,501147102,29426000.0,422185.0,0.193 Xenon Pharmaceuticals Inc.,XENE,, ,98420N105,27134000.0,751639.0,0.178 "CinCor Pharma, Inc.",,,New,17240Y109,26493000.0,807212.0,0.174 DBV Technologies S.A.,DBVT,sponsored adr, ,23306J101,25867000.0,14614264.0,0.169 "IDEAYA Biosciences, Inc.",IDYA,,New,45166A102,24892000.0,1668355.0,0.163 "Design Therapeutics, Inc.",DSGN,, ,25056L103,24021000.0,1436636.0,0.157 "Verastem, Inc.",VSTM,, ,92337C104,22941000.0,26988898.0,0.15 "Altimmune, Inc.",ALT,,Sell,02155H200,22599000.0,1769681.0,0.148 "Biomea Fusion, Inc.",BMEA,, ,09077A106,20583000.0,2104559.0,0.135 Invitae Corporation,NVTA,,Sell,46185L103,20669000.0,8402035.0,0.135 Bicycle Therapeutics plc,BCYC,sponsored ads,New,088786108,19627000.0,843814.0,0.129 Ultragenyx Pharmaceutical Inc.,RARE,, ,90400D108,19503000.0,470974.0,0.128 "Instil Bio, Inc.",TIL,, ,45783C101,18846000.0,3893700.0,0.123 Veru Inc.,VERU,,New,92536C103,18542000.0,1609579.0,0.121 "Relmada Therapeutics, Inc.",RLMD,, ,75955J402,18329000.0,495113.0,0.12 Alkermes plc,ALKS,,Sell,G01767105,18199000.0,815016.0,0.119 Denali Therapeutics Inc.,DNLI,, ,24823R105,18068000.0,588738.0,0.118 Opthea Limited,OPT,sponsored ads,Sell,68386J208,16687000.0,2691391.0,0.109 "bluebird bio, Inc.",BLUE,, ,09609G100,15823000.0,2499715.0,0.104 "Crinetics Pharmaceuticals, Inc.",CRNX,,Sell,22663K107,14449000.0,735716.0,0.095 "Aadi Bioscience, Inc.",,,New,00032Q104,13988000.0,989928.0,0.092 "Tricida, Inc.",TCDA,,Sell,89610F101,13837000.0,1320290.0,0.091 Affimed N.V.,AFMD,, ,N01045108,13589000.0,6596830.0,0.089 "DICE Therapeutics, Inc.",,, ,23345J104,11929000.0,588235.0,0.078 "AnaptysBio, Inc.",ANAB,, ,032724106,10897000.0,427179.0,0.071 "FibroGen, Inc.",FGEN,, ,31572Q808,10612000.0,815718.0,0.069 Zymeworks Inc.,ZYME,, ,98985W102,10507000.0,1708472.0,0.069 Adaptimmune Therapeutics plc,ADAP,sponsored adr, ,00653A107,10568000.0,9830877.0,0.069 POINT Biopharma Global Inc.,PNT,,New,730541109,9037000.0,1169103.0,0.059 "TScan Therapeutics, Inc.",,, ,89854M101,8494000.0,2784792.0,0.056 Invitae Corporation,,note 2.0% 9/1/2024, ,46185LAB9,8148000.0,10300000.0,0.053 "CymaBay Therapeutics, Inc.",CBAY,, ,23257D103,7597000.0,2170464.0,0.05 "Vera Therapeutics, Inc.",VERA,cl a, ,92337R101,7103000.0,333333.0,0.047 "Pacific Biosciences of California, Inc.",PACB,,Sell,69404D108,6547000.0,1127782.0,0.043 "Fulgent Genetics, Inc.",FLGT,,Sell,359664109,6352000.0,166619.0,0.042 Amarin Corporation plc,AMRN,sponsored adr,Sell,023111206,5861000.0,5377113.0,0.038 Achilles Therapeutics plc,ACHL,sponsored ads, ,00449L102,5856000.0,2591366.0,0.038 Vor Biopharma Inc.,VOR,,Buy,929033108,5834000.0,1465925.0,0.038 "Reata Pharmaceuticals, Inc.",RETA,cl a, ,75615P103,5629000.0,223976.0,0.037 "Atreca, Inc.",BCEL,, ,04965G109,5546000.0,3532760.0,0.036 "Kronos Bio, Inc.",KRON,,New,50107A104,5158000.0,1539616.0,0.034 "Nkarta, Inc.",NKTX,, ,65487U108,5264000.0,400000.0,0.034 Talis Biomedical Corporation,TLIS,, ,87424L108,5197000.0,7624835.0,0.034 "Cyteir Therapeutics, Inc.",CYT,, ,23284P103,5076000.0,2643640.0,0.033 "Surrozen, Inc.",,, ,86889P109,5050000.0,2500000.0,0.033 "Edgewise Therapeutics, Inc.",EWTX,, ,28036F105,4920000.0,500000.0,0.032 "Fate Therapeutics, Inc.",FATE,,New,31189P102,4834000.0,215695.0,0.032 "Stoke Therapeutics, Inc.",STOK,,New,86150R107,4742000.0,369327.0,0.031 "Natera, Inc.",NTRA,, ,632307104,4382000.0,100000.0,0.029 "Revolution Medicines, Inc.",RVMD,, ,76155X100,4382000.0,222222.0,0.029 Allakos Inc.,ALLK,, ,01671P100,4303000.0,703050.0,0.028 "Eiger BioPharmaceuticals, Inc.",EIGR,,New,28249U105,4065000.0,539851.0,0.027 "PMV Pharmaceuticals, Inc.",PMVP,,New,69353Y103,3832000.0,322024.0,0.025 "Century Therapeutics, Inc.",IPSC,,New,15673T100,3665000.0,370587.0,0.024 HOOKIPA Pharma Inc.,HOOK,, ,43906K100,3217000.0,2400481.0,0.021 "Athira Pharma, Inc.",ATHA,, ,04746L104,3091000.0,1040834.0,0.02 "MacroGenics, Inc.",MGNX,, ,556099109,3088000.0,892579.0,0.02 "iTeos Therapeutics, Inc.",ITOS,, ,46565G104,2864000.0,150346.0,0.019 "Atara Biotherapeutics, Inc.",ATRA,, ,046513107,2813000.0,744186.0,0.018 "Tango Therapeutics, Inc.",,, ,87583X109,2715000.0,750000.0,0.018 "Syndax Pharmaceuticals, Inc.",SNDX,, ,87164F105,2661000.0,110729.0,0.017 "Otonomy, Inc.",OTIC,,Buy,68906L105,2491000.0,8443134.0,0.016 "Neoleukin Therapeutics, Inc.",NLTX,, ,64049K104,2446000.0,3821740.0,0.016 "Aligos Therapeutics, Inc.",ALGS,, ,01626L105,2284000.0,2076400.0,0.015 "Alector, Inc.",ALEC,, ,014442107,2263000.0,239228.0,0.015 "Aeglea BioTherapeutics, Inc.",AGLE,, ,00773J103,1794000.0,3410106.0,0.012 TCR2 Therapeutics Inc.,TCRR,, ,87808K106,1356000.0,753064.0,0.009 "aTyr Pharma, Inc.",LIFE,,Sell,002120202,604000.0,201361.0,0.004 "Protara Therapeutics, Inc.",TARA,, ,74365U107,591000.0,199671.0,0.004 Foghorn Therapeutics Inc.,FHTX,, ,344174107,386000.0,45027.0,0.003 "Cabaletta Bio, Inc.",CABA,, ,12674W109,430000.0,662063.0,0.003 Insmed Incorporated,INSM,,Sell,457669307,430000.0,19950.0,0.003 "Leap Therapeutics, Inc.",LPTX,, ,52187K101,493000.0,559705.0,0.003 "Kezar Life Sciences, Inc.",KZR,, ,49372L100,533000.0,61946.0,0.003 Genetron Holdings Limited,GTH,ads, ,37186H100,356000.0,455306.0,0.002 "Sera Prognostics, Inc.",,, ,81749D107,322000.0,201562.0,0.002 "Vincerx Pharma, Inc.",VINC,, ,92731L106,333000.0,241379.0,0.002 "Bellicum Pharmaceuticals, Inc.",,, ,079481404,299000.0,249123.0,0.002 "Surrozen, Inc.",,w exp 8/11/2026, ,86889P117,154000.0,833333.0,0.001 "LogicBio Therapeutics, Inc.",LOGC,,Sell,54142F102,38000.0,139105.0,0.0 "NexImmune, Inc.",NEXI,,Exit,65344D109,0.0,-20000.0,0.0 "Passage Bio, Inc.",PASG,,Exit,702712100,0.0,-117161.0,-0.002 Burning Rock Biotech Limited,BNR,sponsored ads,Exit,12233L107,0.0,-209131.0,-0.003 "Inozyme Pharma, Inc.",INZY,,Exit,45790W108,0.0,-106999.0,-0.003 "NGM Biopharmaceuticals, Inc.",NGM,,Exit,62921N105,0.0,-55294.0,-0.004 "Epizyme, Inc.",EPZM,,Exit,29428V104,0.0,-1000000.0,-0.008 "BioAtla, Inc.",BCAB,,Exit,09077B104,0.0,-825000.0,-0.013 "Evofem Biosciences, Inc.",,,Exit,30048L203,0.0,-2583616.0,-0.017 Centessa Pharmaceuticals plc,CNTA,sponsored ads,Exit,152309100,0.0,-1127273.0,-0.031 "Harmony Biosciences Holdings, Inc.",HRMY,,Exit,413197104,0.0,-123600.0,-0.034 "Karuna Therapeutics, Inc.",KRTX,,Exit,48576A100,0.0,-69966.0,-0.05 Merus N.V.,MRUS,,Exit,N5749R100,0.0,-995397.0,-0.128 "Sarepta Therapeutics, Inc.",,dbcv 1.5% 11/15/2024,Exit,803607AB6,0.0,-29174000.0,-0.208 Legend Biotech Corporation,LEGN,sponsored ads,Exit,52490G102,0.0,-856658.0,-0.267