$5.06 Billion is the total value of Orbimed Advisors's 115 reported holdings in Q2 2024. The portfolio turnover from Q1 2024 to Q2 2024 was 26.3% .
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| SVA | SINOVAC BIOTECH LTD | $340,000,000 | 0.0% | 2,718,735 | 0.0% | 6.71% | +7.8% | |
| LLY | Sell | ELI LILLY & CO | $305,656,288 | +8.9% | 337,600 | -6.4% | 6.04% | +17.4% |
| EWTX | EDGEWISE THERAPEUTICS INC | $270,541,195 | -1.3% | 15,021,721 | 0.0% | 5.34% | +6.5% | |
| BSX | BOSTON SCIENTIFIC CORP | $252,053,730 | +12.4% | 3,273,000 | 0.0% | 4.98% | +21.2% | |
| ISRG | INTUITIVE SURGICAL INC | $219,355,535 | +11.5% | 493,100 | 0.0% | 4.33% | +20.2% | |
| BIIB | BIOGEN INC | $208,846,638 | +7.5% | 900,900 | 0.0% | 4.12% | +15.9% | |
| Sell | ENLIVEN THERAPEUTICS INC | $186,014,403 | +17.5% | 7,959,538 | -11.5% | 3.67% | +26.7% | |
| MRK | MERCK & CO INC | $162,920,800 | -6.2% | 1,316,000 | 0.0% | 3.22% | +1.2% | |
| THC | TENET HEALTHCARE CORP | $156,084,099 | +26.6% | 1,173,300 | 0.0% | 3.08% | +36.4% | |
| JANX | Sell | JANUX THERAPEUTICS INC | $124,824,995 | -22.5% | 2,979,828 | -30.3% | 2.46% | -16.4% |
| IONS | Buy | IONIS PHARMACEUTICALS INC | $113,065,391 | +29.6% | 2,372,333 | +17.8% | 2.23% | +39.7% |
| SRPT | Sell | SAREPTA THERAPEUTICS INC | $102,068,000 | +13.0% | 646,000 | -7.4% | 2.02% | +21.8% |
| SYK | STRYKER CORPORATION | $91,527,250 | -4.9% | 269,000 | 0.0% | 1.81% | +2.5% | |
| ANTM | ELEVANCE HEALTH INC | $91,086,666 | +4.5% | 168,100 | 0.0% | 1.80% | +12.7% | |
| ARGX | Buy | ARGENX SEsponsored adr | $89,921,364 | +50.7% | 209,100 | +37.9% | 1.78% | +62.5% |
| Buy | DISC MEDICINE INC | $80,475,685 | -24.1% | 1,785,571 | +4.9% | 1.59% | -18.1% | |
| SBTX | ARS PHARMACEUTICALS INC | $78,639,948 | -16.7% | 9,240,887 | 0.0% | 1.55% | -10.2% | |
| THIRD HARMONIC BIO INC | $75,127,923 | +37.7% | 5,779,071 | 0.0% | 1.48% | +48.4% | ||
| NTRA | Sell | NATERA INC | $74,449,375 | -9.5% | 687,500 | -23.6% | 1.47% | -2.5% |
| TMO | THERMO FISHER SCIENTIFIC INC | $72,996,000 | -4.9% | 132,000 | 0.0% | 1.44% | +2.6% | |
| VRTX | Buy | VERTEX PHARMACEUTICALS INC | $70,776,720 | +38.0% | 151,000 | +23.1% | 1.40% | +48.8% |
| SWTX | SPRINGWORKS THERAPEUTICS INC | $64,315,159 | -23.5% | 1,707,331 | 0.0% | 1.27% | -17.5% | |
| NBIX | Buy | NEUROCRINE BIOSCIENCES INC | $61,703,694 | +5.7% | 448,200 | +5.9% | 1.22% | +13.9% |
| ALNY | New | ALNYLAM PHARMACEUTICALS INC | $60,822,900 | – | 250,300 | +100.0% | 1.20% | – |
| PCVX | Sell | VAXCYTE INC | $60,098,409 | -17.5% | 795,900 | -25.3% | 1.19% | -11.0% |
| KROS | KEROS THERAPEUTICS INC | $57,981,144 | -31.0% | 1,268,734 | 0.0% | 1.14% | -25.6% | |
| CRNX | Sell | CRINETICS PHARMACEUTICALS IN | $57,367,032 | -11.5% | 1,280,800 | -7.5% | 1.13% | -4.5% |
| UNH | Buy | UNITEDHEALTH GROUP INC | $57,037,120 | +64.7% | 112,000 | +60.0% | 1.13% | +77.6% |
| ARRIVENT BIOPHARMA INC | $56,156,934 | +3.9% | 3,027,328 | 0.0% | 1.11% | +12.0% | ||
| ICLR | ICON PLC | $54,575,127 | -6.7% | 174,100 | 0.0% | 1.08% | +0.7% | |
| TERN | TERNS PHARMACEUTICALS INC | $51,886,309 | +3.8% | 7,619,135 | 0.0% | 1.02% | +12.0% | |
| APLS | Buy | APELLIS PHARMACEUTICALS INC | $49,975,408 | -34.5% | 1,302,800 | +0.4% | 0.99% | -29.3% |
| EVH | EVOLENT HEALTH INCcl a | $49,819,359 | -41.7% | 2,605,615 | 0.0% | 0.98% | -37.1% | |
| XTNT | XTANT MED HLDGS INC | $46,062,193 | -46.2% | 73,114,592 | 0.0% | 0.91% | -41.9% | |
| CYTK | Buy | CYTOKINETICS INC | $44,043,247 | -8.0% | 812,906 | +19.1% | 0.87% | -0.8% |
| AMGN | Buy | AMGEN INC | $42,149,505 | +133.8% | 134,900 | +112.8% | 0.83% | +152.1% |
| SIBN | Buy | SI-BONE INC | $41,763,603 | -19.6% | 3,229,977 | +1.7% | 0.82% | -13.3% |
| PRLD | PRELUDE THERAPEUTICS INC | $41,564,265 | -19.6% | 10,909,256 | 0.0% | 0.82% | -13.3% | |
| VRNA | Sell | VERONA PHARMA PLCsponsored ads | $41,381,642 | -24.3% | 2,861,801 | -15.8% | 0.82% | -18.4% |
| Q32 BIO INC | $40,441,117 | +5.3% | 2,252,987 | 0.0% | 0.80% | +13.7% | ||
| ITGR | New | INTEGER HLDGS CORP | $40,436,300 | – | 349,221 | +100.0% | 0.80% | – |
| SNDX | Buy | SYNDAX PHARMACEUTICALS INC | $39,526,409 | -5.0% | 1,925,300 | +10.1% | 0.78% | +2.4% |
| GERN | Sell | GERON CORP | $37,864,268 | -11.0% | 8,930,252 | -30.7% | 0.75% | -4.0% |
| XENE | Buy | XENON PHARMACEUTICALS INC | $33,623,494 | +42.0% | 862,362 | +56.8% | 0.66% | +53.0% |
| DXCM | Buy | DEXCOM INC | $32,868,862 | +68.9% | 289,900 | +106.6% | 0.65% | +82.3% |
| PRELUDE THERAPEUTICS INCnonvoting | $32,149,678 | -10.6% | 12,048,773 | 0.0% | 0.64% | -3.6% | ||
| RYTM | RHYTHM PHARMACEUTICALS INC | $28,940,813 | -5.2% | 704,842 | 0.0% | 0.57% | +2.1% | |
| RNA | Sell | AVIDITY BIOSCIENCES INC | $28,859,504 | +13.8% | 706,475 | -28.9% | 0.57% | +22.6% |
| EXAS | Buy | EXACT SCIENCES CORP | $28,409,576 | +193.0% | 672,416 | +378.9% | 0.56% | +215.2% |
| NPCE | Sell | NEUROPACE INC | $25,751,893 | -51.3% | 3,406,335 | -14.9% | 0.51% | -47.5% |
| DYN | DYNE THERAPEUTICS INC | $24,999,436 | +24.3% | 708,400 | 0.0% | 0.49% | +34.2% | |
| VERA | VERA THERAPEUTICS INCcl a | $24,453,049 | -16.1% | 675,872 | 0.0% | 0.48% | -9.6% | |
| SCPH | SCPHARMACEUTICALS INC | $24,183,947 | -13.3% | 5,559,528 | 0.0% | 0.48% | -6.5% | |
| REGN | REGENERON PHARMACEUTICALS | $23,963,484 | +9.2% | 22,800 | 0.0% | 0.47% | +17.7% | |
| MINERALYS THERAPEUTICS INC | $23,650,661 | -9.4% | 2,021,424 | 0.0% | 0.47% | -2.3% | ||
| IMTX | Buy | IMMATICS N.V | $23,314,147 | +25.3% | 2,006,381 | +13.4% | 0.46% | +34.9% |
| HRTX | Sell | HERON THERAPEUTICS INC | $22,795,031 | -18.6% | 6,512,866 | -35.6% | 0.45% | -12.3% |
| CMPX | COMPASS THERAPEUTICS INC | $22,362,850 | -49.5% | 22,362,850 | 0.0% | 0.44% | -45.5% | |
| MORF | Buy | MORPHIC HLDG INC | $20,867,875 | +6.1% | 612,500 | +9.7% | 0.41% | +14.4% |
| VIR | Buy | VIR BIOTECHNOLOGY INC | $20,648,908 | +218.5% | 2,320,102 | +262.5% | 0.41% | +242.9% |
| CGEM | Buy | CULLINAN THERAPEUTICS INC | $20,015,103 | +126.9% | 1,147,655 | +121.7% | 0.40% | +143.8% |
| ACELYRIN INC | $17,647,546 | -34.7% | 4,001,711 | 0.0% | 0.35% | -29.7% | ||
| Sell | APOGEE THERAPEUTICS INC | $14,918,766 | -68.8% | 379,130 | -47.3% | 0.30% | -66.3% | |
| NEUMORA THERAPEUTICS INC. | $14,745,000 | -28.5% | 1,500,000 | 0.0% | 0.29% | -23.0% | ||
| ACET | ADICET BIO INC | $13,851,039 | -48.5% | 11,447,140 | 0.0% | 0.27% | -44.6% | |
| ADCT | New | ADC THERAPEUTICS SA | $13,641,164 | – | 4,316,824 | +100.0% | 0.27% | – |
| CRVS | CORVUS PHARMACEUTICALS INC | $12,637,450 | +2.2% | 6,943,654 | 0.0% | 0.25% | +10.6% | |
| ABCL | ABCELLERA BIOLOGICS INC | $12,375,073 | -34.7% | 4,180,768 | 0.0% | 0.24% | -29.7% | |
| TYRA BIOSCIENCES INC | $12,290,522 | -2.5% | 768,638 | 0.0% | 0.24% | +5.2% | ||
| TELA | Sell | TELA BIO INC | $11,550,447 | -28.2% | 2,457,542 | -13.3% | 0.23% | -22.4% |
| ALXO | Sell | ALX ONCOLOGY HLDGS INC | $11,423,606 | -62.3% | 1,894,462 | -30.3% | 0.23% | -59.3% |
| RPTX | REPARE THERAPEUTICS INC | $10,964,210 | -29.9% | 3,322,488 | 0.0% | 0.22% | -24.7% | |
| New | SOLVENTUM CORPcall | $10,576,000 | – | 200,000 | +100.0% | 0.21% | – | |
| PMVP | PMV PHARMACEUTICALS INC | $10,489,971 | -4.7% | 6,475,291 | 0.0% | 0.21% | +2.5% | |
| LXRX | Buy | LEXICON PHARMACEUTICALS INC | $9,821,448 | +15.5% | 5,846,100 | +65.1% | 0.19% | +24.4% |
| LYEL | Buy | LYELL IMMUNOPHARMA INC | $9,287,392 | +1987.6% | 6,405,098 | +3110.6% | 0.18% | +2187.5% |
| MRUS | New | MERUS N V | $9,236,437 | – | 156,100 | +100.0% | 0.18% | – |
| SRRK | Sell | SCHOLAR ROCK HLDG CORP | $8,949,602 | -85.9% | 1,074,382 | -69.9% | 0.18% | -84.8% |
| TURNSTONE BIOLOGICS CORP | $8,120,074 | 0.0% | 3,099,265 | 0.0% | 0.16% | +7.4% | ||
| PASG | PASSAGE BIO INC | $8,040,938 | -41.2% | 10,124,576 | 0.0% | 0.16% | -36.4% | |
| SRPT | New | SAREPTA THERAPEUTICS INCcall | $7,900,000 | – | 50,000 | +100.0% | 0.16% | – |
| PGNY | Buy | PROGYNY INC | $7,435,739 | +72.0% | 259,900 | +129.4% | 0.15% | +86.1% |
| CCCC | New | C4 THERAPEUTICS INC | $6,990,328 | – | 1,513,058 | +100.0% | 0.14% | – |
| PFE | New | PFIZER INCcall | $6,995,000 | – | 250,000 | +100.0% | 0.14% | – |
| IKNA | IKENA ONCOLOGY INC | $5,839,941 | +16.2% | 3,539,358 | 0.0% | 0.12% | +25.0% | |
| FOLD | AMICUS THERAPEUTICS INC | $5,657,376 | -15.8% | 570,300 | 0.0% | 0.11% | -8.9% | |
| KRYS | Sell | KRYSTAL BIOTECH INC | $5,502,956 | -16.8% | 29,966 | -19.4% | 0.11% | -9.9% |
| NSPR | INSPIREMD INC | $5,323,485 | +5.3% | 2,133,405 | 0.0% | 0.10% | +12.9% | |
| New | PERSPECTIVE THERAPEUTICS INC | $4,911,920 | – | 492,670 | +100.0% | 0.10% | – | |
| New | STRUCTURE THERAPEUTICS INCsponsored ads | $4,908,750 | – | 125,000 | +100.0% | 0.10% | – | |
| NKTX | NKARTA INC | $4,728,000 | -45.3% | 800,000 | 0.0% | 0.09% | -41.1% | |
| PHGE | Buy | BIOMX INC | $4,629,325 | +127.7% | 13,773,653 | +204.9% | 0.09% | +145.9% |
| VERASTEM INC | $4,556,763 | -74.7% | 1,529,115 | 0.0% | 0.09% | -72.7% | ||
| FATE | FATE THERAPEUTICS INC | $4,445,555 | -55.3% | 1,355,352 | 0.0% | 0.09% | -51.6% | |
| XFOR | X4 PHARMACEUTICALS INC | $4,137,439 | -58.3% | 7,133,515 | 0.0% | 0.08% | -54.9% | |
| SIBN | SI-BONE INCcall | $3,232,500 | -21.0% | 250,000 | 0.0% | 0.06% | -14.7% | |
| MRUS | New | MERUS N Vcall | $2,958,500 | – | 50,000 | +100.0% | 0.06% | – |
| Sell | INVIVYD INC | $2,668,380 | -77.7% | 2,425,800 | -9.8% | 0.05% | -75.8% | |
| MIST | MILESTONE PHARMACEUTICALS IN | $2,640,000 | -26.3% | 2,000,000 | 0.0% | 0.05% | -21.2% | |
| GERN | New | GERON CORPcall | $2,544,000 | – | 600,000 | +100.0% | 0.05% | – |
| ELEV | ELEVATION ONCOLOGY INC | $2,541,443 | -47.4% | 941,275 | 0.0% | 0.05% | -43.2% | |
| TGTX | New | TG THERAPEUTICS INC | $2,369,628 | – | 133,200 | +100.0% | 0.05% | – |
| BMRN | Sell | BIOMARIN PHARMACEUTICAL INC | $2,148,813 | -98.1% | 26,100 | -98.0% | 0.04% | -97.9% |
| CMMB | Sell | CHEMOMAB THERAPEUTICS LTDsponsored ads | $2,045,162 | +17.1% | 2,241,273 | -0.0% | 0.04% | +25.0% |
| ORIC | ORIC PHARMACEUTICALS INC | $2,029,797 | -48.6% | 287,100 | 0.0% | 0.04% | -44.4% | |
| APOLLOMICS INC | $1,806,455 | -71.9% | 8,565,456 | 0.0% | 0.04% | -69.5% | ||
| NXTC | NEXTCURE INC | $1,814,508 | -28.7% | 1,141,200 | 0.0% | 0.04% | -23.4% | |
| VIGIL NEUROSCIENCE INC | $1,795,564 | +17.3% | 448,891 | 0.0% | 0.04% | +25.0% | ||
| DVAX | DYNAVAX TECHNOLOGIES CORP | $1,274,605 | -9.5% | 113,500 | 0.0% | 0.02% | -3.8% | |
| KZR | KEZAR LIFE SCIENCES INC | $1,156,200 | -33.5% | 1,927,000 | 0.0% | 0.02% | -28.1% | |
| Sell | LAKESHORE BIOPHARMA CO LTDordinary shares | $909,833 | -17.6% | 1,404,280 | -8.5% | 0.02% | -10.0% | |
| ONTX | New | TRAWS PHARMA INC | $466,918 | – | 1,045,261 | +100.0% | 0.01% | – |
| XERIS BIOPHARMA HOLDINGS INC | $180,945 | +1.8% | 80,420 | 0.0% | 0.00% | +33.3% | ||
| New | SINGULAR GENOMICS SYSTEMS IN | $152,294 | – | 18,023 | +100.0% | 0.00% | – | |
| OMIC | Exit | SINGULAR GENOMICS SYSTEMS IN | $0 | – | -540,697 | -100.0% | -0.01% | – |
| AFIB | Exit | ACUTUS MED INC | $0 | – | -2,648,386 | -100.0% | -0.01% | – |
| Exit | CALCIMEDICA INC | $0 | – | -297,380 | -100.0% | -0.02% | – | |
| BOLT | Exit | BOLT BIOTHERAPEUTICS INC | $0 | – | -1,541,000 | -100.0% | -0.04% | – |
| ISR | Exit | PERSPECTIVE THERAPEUTICS INC | $0 | – | -6,505,800 | -100.0% | -0.14% | – |
| CTMX | Exit | CYTOMX THERAPEUTICS INC | $0 | – | -3,544,578 | -100.0% | -0.14% | – |
| TXG | Exit | 10X GENOMICS INC | $0 | – | -225,200 | -100.0% | -0.16% | – |
| APLS | Exit | APELLIS PHARMACEUTICALS INCcall | $0 | – | -150,000 | -100.0% | -0.16% | – |
| Exit | VENTYX BIOSCIENCES INC | $0 | – | -1,870,456 | -100.0% | -0.19% | – | |
| AVTE | Exit | AEROVATE THERAPEUTICS INC | $0 | – | -565,374 | -100.0% | -0.31% | – |
| ARWR | Exit | ARROWHEAD PHARMACEUTICALS IN | $0 | – | -739,651 | -100.0% | -0.39% | – |
| KNTE | Exit | KINNATE BIOPHARMA INC | $0 | – | -8,009,729 | -100.0% | -0.39% | – |
| Exit | PRAXIS PRECISION MEDICINES I | $0 | – | -460,512 | -100.0% | -0.52% | – | |
| ESPR | Exit | ESPERION THERAPEUTICS INC NE | $0 | – | -13,708,731 | -100.0% | -0.67% | – |
| ALPN | Exit | ALPINE IMMUNE SCIENCES INC | $0 | – | -2,680,496 | -100.0% | -1.95% | – |
Other managers
Other managers that, in addition to the filing manager(s), that filed the EDGAR filing(s):
Original filings
The following EDGAR filing(s) were analyzed to create this report:
- View 13F-HR filed 2024-08-14
About Orbimed Advisors
Orbimed Advisors is a leading healthcare-focused investment firm that manages over $16 billion in assets. The firm was founded in 1998 by Samuel Isaly, who has over 50 years of experience in the healthcare industry. Isaly is widely regarded as a pioneer in the field of healthcare investing and has been recognized for his contributions to the industry by numerous organizations.
Orbimed Advisors has a team of over 100 professionals, including investment professionals, research analysts, and operational experts. The firm has offices in New York, San Francisco, Shanghai, and Mumbai, and invests in companies across the healthcare spectrum, including biotechnology, pharmaceuticals, medical devices, and healthcare services.
The firm's investment philosophy is based on a deep understanding of the healthcare industry and a rigorous approach to due diligence. Orbimed Advisors seeks to identify companies with innovative technologies and strong management teams that have the potential to transform the healthcare landscape.
Orbimed Advisors has a strong track record of success, with numerous successful investments in companies such as Juno Therapeutics, Spark Therapeutics, and Kite Pharma. The firm's leadership team, which includes CEO Sven Borho, COO Jonathan Silverstein, and Chief Investment Officer Carl Gordon, has decades of experience in the healthcare industry and is widely respected for their expertise and insights.
Overall, Orbimed Advisors is a leading healthcare investment firm that has a proven track record of success and a deep understanding of the healthcare industry. Investors looking to gain exposure to the healthcare sector may want to consider Orbimed Advisors as a potential investment opportunity.
It's important to note that this information is for educational purposes only and has not been fact-checked. As with any investment, it's important to do your own research and consult with a financial advisor before making any investment decisions.
Top long-term holdings
| Name | Quarters owned | Latest quarter owned | Max weighting |
|---|---|---|---|
| BIOGEN INC | 45 | Q2 2024 | 5.0% |
| VERTEX PHARMACEUTICALS INC | 45 | Q2 2024 | 3.7% |
| THERMO FISHER SCIENTIFIC INC | 45 | Q2 2024 | 3.2% |
| SINOVAC BIOTECH LTD | 44 | Q2 2024 | 7.2% |
| NEUROCRINE BIOSCIENCES INC | 44 | Q2 2024 | 2.7% |
| BOSTON SCIENTIFIC CORP | 43 | Q2 2024 | 5.6% |
| AMGEN INC | 43 | Q2 2024 | 5.5% |
| INTUITIVE SURGICAL INC | 43 | Q2 2024 | 4.3% |
| STRYKER CORPORATION | 42 | Q2 2024 | 2.2% |
| BRISTOL-MYERS SQUIBB CO | 40 | Q2 2023 | 5.2% |
View Orbimed Advisors's complete holdings history.
Latest significant ownerships (13-D/G)
| Filed | Shares | Percentage | |
|---|---|---|---|
| Disc Medicine, Inc. | June 20, 2024 | 1,785,571 | 6.0% |
| Enliven Therapeutics, Inc. | May 20, 2024 | 7,918,163 | 16.8% |
| Corvus Pharmaceuticals, Inc. | May 08, 2024 | 6,943,654 | 11.1% |
| Passage BIO, Inc. | April 12, 2024 | 8,034,000 | 13.0% |
| Q32 Bio Inc. | March 28, 2024 | 2,252,987 | 18.9% |
| Compass Therapeutics, Inc. | March 22, 2024 | 18,791,422 | 13.7% |
| Adicet Bio, Inc. | March 21, 2024 | 9,772,598 | 11.9% |
| NextCure, Inc. | March 08, 2024 | 1,268,013 | 4.5% |
| Kinnate Biopharma Inc. | February 21, 2024 | 7,559,729 | 16.1% |
| ALX ONCOLOGY HOLDINGS INC | February 14, 2024 | 2,255,000 | 4.5% |
View Orbimed Advisors's complete significant-ownership history.
Latest filings
| Type | Filed |
|---|---|
| SC 13D/A | 2024-10-01 |
| 3 | 2024-09-23 |
| 4 | 2024-09-23 |
| SC 13D | 2024-09-23 |
| SC 13D | 2024-09-23 |
| 4 | 2024-09-18 |
| 4 | 2024-09-17 |
| 144 | 2024-09-16 |
| SC 13D/A | 2024-09-16 |
| 3 | 2024-09-12 |
View Orbimed Advisors's complete filings history.
All filings
- Holdings (13F-HR)
- Significant ownership (13-D/G)
- Insider transactions (4, 5, 6)
- Events (8-K)
- Shareholder votes (proxy)
View complete filings history.