Name,Ticker,Title of class,Class,Change,CUSIP,Value,Shares or principal amount,Weighting SINOVAC BIOTECH LTD,SVA,, ,P8696W104,340500000.0,2718735.0,6.321 BRISTOL-MYERS SQUIBB CO,BMY,,Buy,110122108,183761000.0,2584900.0,3.411 HUMANA INC,HUM,,Sell,444859102,169186000.0,348700.0,3.141 SPRINGWORKS THERAPEUTICS INC,SWTX,,Sell,85205L107,157655000.0,5525926.0,2.927 BOSTON SCIENTIFIC CORP,BSX,,Sell,101137107,150977000.0,3898200.0,2.803 BIOMARIN PHARMACEUTICAL INC,BMRN,,Buy,09061G101,145576000.0,1717310.0,2.702 EDGEWISE THERAPEUTICS INC,EWTX,,Buy,28036F105,143341000.0,14567176.0,2.661 UNITEDHEALTH GROUP INC,UNH,,Sell,91324P102,134947000.0,267200.0,2.505 PFIZER INC,PFE,,Sell,717081103,113732000.0,2599000.0,2.111 THIRD HARMONIC BIO INC,,,New,88427A107,109629000.0,5779071.0,2.035 VERTEX PHARMACEUTICALS INC,VRTX,,Sell,92532F100,108056000.0,373200.0,2.006 TRICIDA INC,TCDA,, ,89610F101,107744000.0,10280947.0,2.0 INTUITIVE SURGICAL INC,ISRG,,Buy,46120E602,107347000.0,572700.0,1.993 ADICET BIO INC,ACET,,Sell,007002108,105898000.0,7447140.0,1.966 SEAGEN INC,SGEN,,Buy,81181C104,104347000.0,762600.0,1.937 THERMO FISHER SCIENTIFIC INC,TMO,,Buy,883556102,102554000.0,202200.0,1.904 SAREPTA THERAPEUTICS INC,SRPT,,Buy,803607100,101531000.0,918500.0,1.885 MIRATI THERAPEUTICS INC,MRTX,,Buy,60468T105,99095000.0,1418892.0,1.84 THESEUS PHARMACEUTICALS INC,,, ,88369M101,98842000.0,17041668.0,1.835 NEUROCRINE BIOSCIENCES INC,NBIX,,Buy,64125C109,95222000.0,896545.0,1.768 ARGENX SE,ARGX,sponsored adr,Buy,04016X101,95218000.0,269700.0,1.768 STRYKER CORPORATION,SYK,,Sell,863667101,85695000.0,423100.0,1.591 ABBVIE INC,ABBV,,Sell,00287Y109,80526000.0,600000.0,1.495 EDWARDS LIFESCIENCES CORP,EW,,Sell,28176E108,79845000.0,966300.0,1.482 PMV PHARMACEUTICALS INC,PMVP,, ,69353Y103,78101000.0,6563077.0,1.45 EVOLENT HEALTH INC,EVH,cl a,Buy,30050B101,71670000.0,1994717.0,1.33 PRELUDE THERAPEUTICS INC,PRLD,, ,74065P101,66362000.0,10039691.0,1.232 NATERA INC,NTRA,,Sell,632307104,65956000.0,1505153.0,1.224 KEROS THERAPEUTICS INC,KROS,, ,492327101,63180000.0,1679417.0,1.173 CRINETICS PHARMACEUTICALS IN,CRNX,, ,22663K107,62787000.0,3196876.0,1.166 MERSANA THERAPEUTICS INC,MRSN,, ,59045L106,60917000.0,9011437.0,1.131 PRELUDE THERAPEUTICS INC,,nonvoting, ,000000000,60506000.0,12147877.0,1.123 BIOGEN INC,BIIB,,Buy,09062X103,59968000.0,224600.0,1.113 SI-BONE INC,SIBN,, ,825704109,58805000.0,3368000.0,1.092 VERONA PHARMA PLC,VRNA,sponsored ads, ,925050106,58201000.0,5694841.0,1.08 ARCUTIS BIOTHERAPEUTICS INC,ARQT,,Sell,03969K108,53508000.0,2800000.0,0.993 GUARDANT HEALTH INC,GH,,Sell,40131M109,53421000.0,992400.0,0.992 XTANT MED HLDGS INC,XTNT,,Buy,98420P308,52628000.0,73114592.0,0.977 ALNYLAM PHARMACEUTICALS INC,ALNY,,New,02043Q107,50140000.0,250500.0,0.931 COMPASS THERAPEUTICS INC,CMPX,, ,20454B104,50071000.0,21960850.0,0.929 BELLUS HEALTH INC NEW,BLU,,Buy,07987C204,48971000.0,4634900.0,0.909 KINNATE BIOPHARMA INC,KNTE,, ,49705R105,48321000.0,4043629.0,0.897 SYNDAX PHARMACEUTICALS INC,SNDX,,Sell,87164F105,48216000.0,2006500.0,0.895 SILVERBACK THERAPEUTICS INC,SBTX,, ,82835W108,46152000.0,8740887.0,0.857 TERNS PHARMACEUTICALS INC,TERN,,Buy,880881107,44064000.0,7481204.0,0.818 ACLARIS THERAPEUTICS INC,ACRS,,Buy,00461U105,43418000.0,2758434.0,0.806 PROGYNY INC,PGNY,,Buy,74340E103,42028000.0,1134053.0,0.78 ABCELLERA BIOLOGICS INC,ABCL,, ,00288U106,41348000.0,4180768.0,0.768 XENON PHARMACEUTICALS INC,XENE,,Sell,98420N105,41057000.0,1137300.0,0.762 REPARE THERAPEUTICS INC,RPTX,, ,760273102,40302000.0,3322488.0,0.748 CHINOOK THERAPEUTICS INC,KDNY,,Buy,16961L106,39896000.0,2029300.0,0.741 VECTIVBIO HLDG AG,VECT,, ,H9060V101,38841000.0,6473561.0,0.721 JANUX THERAPEUTICS INC,JANX,, ,47103J105,38405000.0,2836386.0,0.713 IONIS PHARMACEUTICALS INC,IONS,,Buy,462222100,34008000.0,768900.0,0.631 TENET HEALTHCARE CORP,THC,,Sell,88033G407,33181000.0,643300.0,0.616 SCPHARMACEUTICALS INC,SCPH,, ,810648105,31277000.0,4797148.0,0.581 TRAVERE THERAPEUTICS INC,TVTX,,Buy,89422G107,30877000.0,1253130.0,0.573 RAPT THERAPEUTICS INC,RAPT,,Buy,75382E109,30101000.0,1251070.0,0.559 UNIQURE NV,QURE,,Buy,N90064101,29960000.0,1597000.0,0.556 ALPINE IMMUNE SCIENCES INC,ALPN,, ,02083G100,29387000.0,4081592.0,0.546 ALX ONCOLOGY HLDGS INC,ALXO,,Buy,00166B105,27475000.0,2871000.0,0.51 BIOHAVEN PHARMACTL HLDG CO L,BHVN,,Sell,G11196105,25815000.0,170769.0,0.479 TELA BIO INC,TELA,, ,872381108,25795000.0,3027542.0,0.479 GRACELL BIOTECHNOLOGIES INC,GRCL,sponsored ads, ,38406L103,25389000.0,7884870.0,0.471 89BIO INC,ETNB,, ,282559103,21185000.0,3658869.0,0.393 IOVANCE BIOTHERAPEUTICS INC,IOVA,,Sell,462260100,19231000.0,2007458.0,0.357 GH RESEARCH PLC,GHRS,ordinary shares, ,G3855L106,18848000.0,1622060.0,0.35 MEIRAGTX HLDGS PLC,MGTX,,Sell,G59665102,17729000.0,2108143.0,0.329 VAXCYTE INC,PCVX,,Sell,92243G108,17230000.0,717900.0,0.32 DECIBEL THERAPEUTICS INC,DBTX,, ,24343R106,17110000.0,4945192.0,0.318 INVIVYD INC,,,Buy,00534A102,16496000.0,5270400.0,0.306 KEZAR LIFE SCIENCES INC,KZR,,Buy,49372L100,15254000.0,1771700.0,0.283 KALVISTA PHARMACEUTICALS INC,KALV,,Buy,483497103,15119000.0,1042000.0,0.281 2SEVENTY BIO INC,,,New,901384107,15151000.0,1041300.0,0.281 NEUROPACE INC,NPCE,, ,641288105,15046000.0,4012281.0,0.279 VERASTEM INC,VSTM,,New,92337C104,14620000.0,17200000.0,0.271 RXSIGHT INC,,,Sell,78349D107,14434000.0,1202833.0,0.268 AEROVATE THERAPEUTICS INC,AVTE,,Buy,008064107,13181000.0,795000.0,0.245 BRIDGEBIO PHARMA INC,,note 2.250% 2/0, ,10806XAD4,12509000.0,30000000.0,0.232 BRIDGEBIO PHARMA INC,,note 2.500% 3/1, ,10806XAB8,11760000.0,20000000.0,0.218 PASSAGE BIO INC,PASG,, ,702712100,11165000.0,8931999.0,0.207 MIRUM PHARMACEUTICALS INC,MIRM,,Buy,604749101,10965000.0,521891.0,0.204 IKENA ONCOLOGY INC,IKNA,, ,45175G108,10415000.0,2933941.0,0.193 CINCOR PHARMA INC,,,New,17240Y109,10312000.0,314202.0,0.191 IMARA INC,IMRA,, ,45249V107,10001000.0,4386568.0,0.186 FUSION PHARMACEUTICALS INC,FUSN,, ,36118A100,9707000.0,3224770.0,0.18 GEMINI THERAPEUTICS INC,GMTX,,Sell,36870G105,9555000.0,5826223.0,0.177 MEREO BIOPHARMA GROUP PLC,MREO,spon ads,Buy,589492107,9132000.0,10605522.0,0.17 X4 PHARMACEUTICALS INC,XFOR,,Buy,98420X103,8596000.0,5026817.0,0.16 CULLINAN ONCOLOGY INC,CGEM,,Sell,230031106,8170000.0,637287.0,0.152 ARCUS BIOSCIENCES INC,RCUS,,New,03969F109,7926000.0,303000.0,0.147 VENTYX BIOSCIENCES INC,,,Sell,92332V107,7855000.0,225000.0,0.146 GALECTO INC,GLTO,, ,36322Q107,7732000.0,4090937.0,0.144 EYEPOINT PHARMACEUTICALS INC,EYPT,,Buy,30233G209,7680000.0,970860.0,0.143 NEXTCURE INC,NXTC,, ,65343E108,7455000.0,2711013.0,0.138 PULMONX CORP,LUNG,, ,745848101,7247000.0,435000.0,0.135 JOUNCE THERAPEUTICS INC,JNCE,, ,481116101,6854000.0,2928900.0,0.127 ORIC PHARMACEUTICALS INC,ORIC,, ,68622P109,6680000.0,2087568.0,0.124 CHEMOMAB THERAPEUTICS LTD,CMMB,sponsored ads, ,16385C104,6420000.0,2578174.0,0.119 SPDR SER TR,XBI,s&p biotech,Sell,78464A870,6060000.0,76400.0,0.112 VAXCYTE INC,PCVX,,New,92243G108,6000000.0,250000.0,0.111 SYNLOGIC INC,SYBX,, ,87166L100,5728000.0,6029995.0,0.106 CORVUS PHARMACEUTICALS INC,CRVS,, ,221015100,5683000.0,6943654.0,0.105 CYBIN INC,CLXPF,,Sell,23256X100,5082000.0,10453600.0,0.094 LILLY ELI & CO,LLY,,New,532457108,4850000.0,15000.0,0.09 HERON THERAPEUTICS INC,HRTX,,New,427746102,4739000.0,1123000.0,0.088 SCHOLAR ROCK HLDG CORP,SRRK,,Sell,80706P103,4629000.0,667943.0,0.086 GRAYBUG VISION INC,GRAY,, ,38942Q103,3915000.0,4163347.0,0.073 APPLIED THERAPEUTICS INC,APLT,, ,03828A101,3953000.0,4250000.0,0.073 VIGIL NEUROSCIENCE INC,,, ,92673K108,3742000.0,411191.0,0.069 SEAGEN INC,SGEN,,Sell,81181C104,3421000.0,25000.0,0.064 ACHILLES THERAPEUTICS PLC,ACHL,sponsored ads,Sell,00449L102,3307000.0,1463251.0,0.061 MAGENTA THERAPEUTICS INC,MGTA,, ,55910K108,3174000.0,2250953.0,0.059 AMNEAL PHARMACEUTICALS INC,AMRX,,New,03168L105,3199000.0,1583490.0,0.059 BURNING ROCK BIOTECH LTD,BNR,sponsored ads,Sell,12233L107,3066000.0,1282816.0,0.057 HARPOON THERAPEUTICS INC,HARP,,Sell,41358P106,2935000.0,3025908.0,0.054 DYNE THERAPEUTICS INC,DYN,,New,26818M108,2799000.0,220400.0,0.052 GRAPHITE BIO INC,GRPH,, ,38870X104,2689000.0,848412.0,0.05 PROTARA THERAPEUTICS INC,TARA,, ,74365U107,2459000.0,830641.0,0.046 ACUTUS MED INC,AFIB,, ,005111109,2331000.0,2648386.0,0.043 LOGICBIO THERAPEUTICS INC,LOGC,, ,54142F102,2307000.0,8466783.0,0.043 PYXIS ONCOLOGY INC,,,New,747324101,1671000.0,848252.0,0.031 ONCOCYTE CORP,OCX,,Sell,68235C107,1374000.0,1882768.0,0.026 SINGULAR GENOMICS SYSTEMS IN,OMIC,, ,82933R100,1352000.0,540697.0,0.025 ESSA PHARMA INC,EPIX,,New,29668H708,1166000.0,640645.0,0.022 BOLT BIOTHERAPEUTICS INC,BOLT,,New,097702104,1141000.0,771059.0,0.021 AEGLEA BIOTHERAPEUTICS INC,AGLE,, ,00773J103,945000.0,1797221.0,0.018 MONTE ROSA THERAPEUTICS INC,GLUE,,New,61225M102,960000.0,117455.0,0.018 BIOMX INC,PHGE,, ,09090D103,957000.0,2813489.0,0.018 VOR BIOPHARMA INC,VOR,,Sell,929033108,445000.0,111808.0,0.008 LONGBOARD PHARMACEUTICALS IN,LBPH,, ,54300N103,422000.0,113500.0,0.008 APTINYX INC,APTX,,Exit,03836N103,0.0,-538500.0,-0.005 TALARIS THERAPEUTICS INC,TALS,,Exit,87410C104,0.0,-235995.0,-0.019 SONENDO INC,,,Exit,835431107,0.0,-723478.0,-0.023 SIGHT SCIENCES INC,,,Exit,82657M105,0.0,-200000.0,-0.033 GUARDANT HEALTH INC,GH,,Exit,40131M109,0.0,-50000.0,-0.037 9 METERS BIOPHARMA INC,NMTR,,Exit,654405109,0.0,-8505729.0,-0.04 ABCELLERA BIOLOGICS INC,ABCL,,Exit,00288U106,0.0,-250000.0,-0.048 CELLDEX THERAPEUTICS INC NEW,CLDX,,Exit,15117B202,0.0,-112700.0,-0.055 CYTOMX THERAPEUTICS INC,CTMX,,Exit,23284F105,0.0,-2124975.0,-0.07 NOVAVAX INC,NVAX,,Exit,670002401,0.0,-75000.0,-0.07 NANOSTRING TECHNOLOGIES INC,,note 2.625% 3/0,Exit,63009RAD1,0.0,-6000000.0,-0.088 IMMUNOCORE HLDGS PLC,IMCR,ads,Exit,45258D105,0.0,-131100.0,-0.089 NATERA INC,NTRA,,Exit,632307104,0.0,-150000.0,-0.096 MEREO BIOPHARMA GROUP PLC,MREO,ads,Exit,589492107,0.0,-7109954.0,-0.144 ERASCA INC,,,Exit,29479A108,0.0,-1667693.0,-0.168 DANAHER CORPORATION,DHRPRB,5% conv pfd b,Exit,235851409,0.0,-8039.0,-0.193 MILESTONE PHARMACEUTICALS IN,MIST,,Exit,59935V107,0.0,-1817521.0,-0.203 VISTAGEN THERAPEUTICS INC,VTGN,,Exit,92840H202,0.0,-13421283.0,-0.214 SIGNIFY HEALTH INC,SGFY,,Exit,82671G100,0.0,-900000.0,-0.225 THERAVANCE BIOPHARMA INC,TBPH,,Exit,G8807B106,0.0,-1370250.0,-0.225 IVERIC BIO INC,ISEE,,Exit,46583P102,0.0,-1361400.0,-0.237 REGENERON PHARMACEUTICALS,REGN,,Exit,75886F107,0.0,-22200.0,-0.238 AMGEN INC,AMGN,,Exit,031162100,0.0,-57100.0,-0.252 GILEAD SCIENCES INC,GILD,,Exit,375558103,0.0,-287600.0,-0.322 GLOBAL BLOOD THERAPEUTICS IN,GBT,,Exit,37890U108,0.0,-2044000.0,-1.183 SIERRA ONCOLOGY INC,SRRA,,Exit,82640U404,0.0,-1964770.0,-1.958 TURNING POINT THERAPEUTICS I,TPTX,,Exit,90041T108,0.0,-2012250.0,-2.744 HORIZON THERAPEUTICS PUB L,HZNP,,Exit,G46188101,0.0,-2108555.0,-3.047