$25 Billion is the total value of Baker Brothers Advisors's 120 reported holdings in Q3 2020. The portfolio turnover from Q2 2020 to Q3 2020 was 19.3% .
Value | Shares | ↓ Weighting | ||||||
---|---|---|---|---|---|---|---|---|
SGEN | New | Seagen Inc. | $9,250,154,000 | – | 47,269,424 | +100.0% | 36.96% | – |
BGNE | Buy | BeiGene, Ltd.sponsored adr | $3,810,109,000 | +71.7% | 13,301,597 | +12.9% | 15.22% | +55.6% |
INCY | Buy | Incyte Corporation | $2,871,626,000 | -13.7% | 31,999,398 | +0.0% | 11.48% | -21.8% |
ACAD | ACADIA Pharmaceuticals Inc. | $1,728,564,000 | -14.9% | 41,904,586 | 0.0% | 6.91% | -22.9% | |
ALXN | Alexion Pharmaceuticals, Inc. | $1,002,498,000 | +2.0% | 8,760,794 | 0.0% | 4.01% | -7.6% | |
KOD | Buy | Kodiak Sciences Inc. | $731,372,000 | +16.8% | 12,352,175 | +6.7% | 2.92% | +5.8% |
BMRN | BioMarin Pharmaceutical Inc. | $577,393,000 | -38.3% | 7,589,294 | 0.0% | 2.31% | -44.1% | |
ASND | Buy | Ascendis Pharma A/Ssponsored adr | $546,334,000 | +9.0% | 3,540,270 | +4.4% | 2.18% | -1.3% |
NVTA | Invitae Corporation | $513,739,000 | +43.1% | 11,850,962 | 0.0% | 2.05% | +29.7% | |
MYOK | Sell | MyoKardia, Inc. | $410,264,000 | +34.2% | 3,009,344 | -4.9% | 1.64% | +21.5% |
PRLD | New | Prelude Therapeutics Incorporated | $304,875,000 | – | 10,118,636 | +100.0% | 1.22% | – |
ARGX | argenx SEsponsored adr | $267,654,000 | +16.6% | 1,019,557 | 0.0% | 1.07% | +5.6% | |
MRTX | Mirati Therapeutics, Inc. | $234,095,000 | +45.4% | 1,409,784 | 0.0% | 0.94% | +31.7% | |
IGMS | Buy | IGM Biosciences, Inc. | $232,092,000 | +1.1% | 3,144,446 | +0.0% | 0.93% | -8.4% |
EXAS | Exact Sciences Corporation | $188,214,000 | +17.3% | 1,846,139 | 0.0% | 0.75% | +6.2% | |
MDGL | Buy | Madrigal Pharmaceuticals, Inc. | $178,002,000 | +4.8% | 1,499,213 | +0.0% | 0.71% | -5.1% |
AMRN | Sell | Amarin Corporation plcsponsored adr | $134,799,000 | -43.5% | 32,018,867 | -7.2% | 0.54% | -48.8% |
HRTX | Sell | Heron Therapeutics, Inc. | $88,842,000 | +0.4% | 5,994,704 | -0.4% | 0.36% | -9.0% |
FMTX | Sell | Forma Therapeutics Holdings, Inc. | $88,292,000 | -5.0% | 1,771,509 | -11.4% | 0.35% | -13.9% |
CERS | Cerus Corporation | $85,845,000 | -5.2% | 13,713,195 | 0.0% | 0.34% | -14.0% | |
ZYME | Zymeworks Inc. | $79,581,000 | +29.1% | 1,708,472 | 0.0% | 0.32% | +16.9% | |
INSM | Sell | Insmed Incorporated | $73,045,000 | -12.3% | 2,272,712 | -24.9% | 0.29% | -20.7% |
AXSM | Sell | Axsome Therapeutics, Inc. | $68,383,000 | -17.7% | 959,757 | -5.0% | 0.27% | -25.4% |
NBIX | Sell | Neurocrine Biosciences, Inc. | $65,098,000 | -41.2% | 676,975 | -25.4% | 0.26% | -46.7% |
KYMR | New | Kymera Therapeutics, Inc. | $63,302,000 | – | 1,959,211 | +100.0% | 0.25% | – |
NRIX | New | Nurix Therapeutics, Inc. | $62,451,000 | – | 1,788,921 | +100.0% | 0.25% | – |
ALLK | Sell | Allakos Inc. | $56,890,000 | +7.6% | 698,469 | -5.0% | 0.23% | -2.6% |
ADCT | ADC Therapeutics SA | $55,671,000 | -29.5% | 1,687,500 | 0.0% | 0.22% | -36.2% | |
RYTM | Sell | Rhythm Pharmaceuticals, Inc. | $53,550,000 | -11.1% | 2,471,155 | -8.5% | 0.21% | -19.5% |
HZNP | Buy | Horizon Therapeutics Public Ltd Co | $51,774,000 | +365.8% | 666,500 | +233.2% | 0.21% | +322.4% |
GBT | Buy | Global Blood Therapeutics, Inc. | $50,749,000 | +1610.4% | 920,375 | +1858.2% | 0.20% | +1461.5% |
ADAP | Sell | Adaptimmune Therapeutics plcsponsored adr | $50,516,000 | -24.4% | 6,330,354 | -5.2% | 0.20% | -31.5% |
BCEL | Atreca, Inc. | $49,353,000 | -34.4% | 3,532,760 | 0.0% | 0.20% | -40.7% | |
CCXI | Sell | ChemoCentryx, Inc. | $49,310,000 | -9.3% | 899,821 | -4.8% | 0.20% | -17.9% |
NLTX | Buy | Neoleukin Therapeutics, Inc. | $45,861,000 | -18.7% | 3,821,740 | +12.5% | 0.18% | -26.5% |
BCRX | Sell | BioCryst Pharmaceuticals, Inc. | $43,610,000 | -33.5% | 12,695,818 | -7.8% | 0.17% | -39.8% |
KNSA | Kiniksa Pharmaceuticals, Ltd. | $42,890,000 | -39.9% | 2,799,577 | 0.0% | 0.17% | -45.7% | |
Neurocrine Biosciences, Inc.note 2.25% 5/15/2024 | $42,342,000 | -17.2% | 30,770,000 | 0.0% | 0.17% | -25.2% | ||
KRYS | Sell | Krystal Biotech, Inc. | $33,372,000 | -1.5% | 775,192 | -5.2% | 0.13% | -10.7% |
PACB | New | Pacific Biosciences of California, Inc. | $32,078,000 | – | 3,250,000 | +100.0% | 0.13% | – |
PTGX | Sell | Protagonist Therapeutics, Inc. | $31,206,000 | -7.6% | 1,596,198 | -16.5% | 0.12% | -16.1% |
AGLE | Aeglea BioTherapeutics, Inc. | $31,051,000 | -23.4% | 4,379,592 | 0.0% | 0.12% | -30.7% | |
ALT | Buy | Altimmune, Inc. | $29,132,000 | +29.1% | 2,206,955 | +4.7% | 0.12% | +16.0% |
APLS | Apellis Pharmaceuticals, Inc. | $27,049,000 | -7.6% | 896,551 | 0.0% | 0.11% | -16.3% | |
ASMB | Sell | Assembly Biosciences, Inc. | $25,341,000 | -29.5% | 1,541,418 | -0.0% | 0.10% | -36.5% |
DBVT | DBV Technologies S.A.sponsored adr | $25,283,000 | -60.6% | 14,614,264 | 0.0% | 0.10% | -64.3% | |
MRUS | Merus N.V. | $24,450,000 | -25.4% | 2,037,469 | 0.0% | 0.10% | -32.4% | |
AUPH | Sell | Aurinia Pharmaceuticals Inc. | $23,834,000 | -13.8% | 1,618,029 | -4.9% | 0.10% | -22.1% |
CBAY | Buy | Cymabay Therapeutics, Inc. | $23,548,000 | +343.0% | 3,252,542 | +113.6% | 0.09% | +308.7% |
ALKS | Buy | Alkermes plc | $22,519,000 | -6.8% | 1,359,001 | +9.2% | 0.09% | -15.9% |
FLGT | Sell | Fulgent Genetics, Inc. | $21,869,000 | +140.0% | 546,189 | -4.1% | 0.09% | +117.5% |
ADPT | Sell | Adaptive Biotechnologies Corporation | $21,423,000 | -4.5% | 440,539 | -5.0% | 0.09% | -13.1% |
IMMU | Sell | Immunomedics, Inc. | $20,211,000 | +72.8% | 237,694 | -28.0% | 0.08% | +55.8% |
NVAX | Sell | Novavax, Inc. | $20,302,000 | +0.9% | 187,376 | -22.4% | 0.08% | -9.0% |
ALBO | Buy | Albireo Pharma, Inc. | $18,322,000 | +87.4% | 549,047 | +48.8% | 0.07% | +69.8% |
FREQ | Buy | Frequency Therapeutics, Inc. | $18,241,000 | -17.0% | 949,555 | +0.4% | 0.07% | -24.7% |
New | Invitae Corporationnote 2.0% 9/1/2024 | $16,905,000 | – | 10,300,000 | +100.0% | 0.07% | – | |
ATHA | New | Athira Pharma, Inc. | $16,288,000 | – | 882,352 | +100.0% | 0.06% | – |
XNCR | Sell | Xencor, Inc. | $15,909,000 | +14.7% | 410,142 | -4.2% | 0.06% | +4.9% |
BioMarin Pharmaceutical Inc.note 0.599% 8/1/2024 | $15,650,000 | -14.7% | 15,000,000 | 0.0% | 0.06% | -22.2% | ||
HRMY | New | Harmony Biosciences Holdings, Inc. | $13,560,000 | – | 400,000 | +100.0% | 0.05% | – |
GWPH | Sell | GW Pharmaceuticals plcads | $13,507,000 | -40.5% | 138,745 | -25.0% | 0.05% | -46.0% |
BLUE | Sell | bluebird bio, Inc. | $13,595,000 | -16.0% | 252,000 | -4.9% | 0.05% | -23.9% |
MIRM | Sell | Mirum Pharmaceuticals, Inc. | $10,656,000 | -6.1% | 553,009 | -5.2% | 0.04% | -14.0% |
IMTX | New | Immatics N.V. | $10,625,000 | – | 1,001,414 | +100.0% | 0.04% | – |
VXRT | Sell | Vaxart, Inc. | $10,415,000 | -28.2% | 1,566,121 | -4.5% | 0.04% | -34.4% |
IDRA | Idera Pharmaceuticals, Inc. | $9,863,000 | +19.6% | 4,608,786 | 0.0% | 0.04% | +8.3% | |
UROV | Sell | Urovant Sciences Ltd. | $9,139,000 | -7.1% | 978,505 | -2.1% | 0.04% | -14.0% |
SGMO | Sell | Sangamo Therapeutics, Inc. | $8,976,000 | +0.2% | 949,823 | -5.0% | 0.04% | -10.0% |
XENE | Sell | Xenon Pharmaceuticals Inc. | $8,417,000 | -16.0% | 760,308 | -4.9% | 0.03% | -22.7% |
ISEE | Sell | IVERIC bio, Inc. | $7,930,000 | -4.9% | 1,406,037 | -14.0% | 0.03% | -13.5% |
QURE | Sell | uniQure N.V. | $7,159,000 | -31.2% | 194,383 | -15.8% | 0.03% | -37.0% |
ANAB | Sell | AnaptysBio, Inc. | $7,187,000 | -37.4% | 487,243 | -5.1% | 0.03% | -43.1% |
CABA | Cabaletta Bio, Inc. | $6,898,000 | -2.7% | 636,363 | 0.0% | 0.03% | -9.7% | |
HOOK | HOOKIPA Pharma Inc. | $6,634,000 | -18.5% | 700,481 | 0.0% | 0.03% | -25.0% | |
BNR | Sell | Burning Rock Biotech Limitedsponsored ads | $5,951,000 | -11.9% | 237,300 | -5.1% | 0.02% | -20.0% |
KRTX | Sell | Karuna Therapeutics, Inc. | $6,014,000 | -34.2% | 77,776 | -5.1% | 0.02% | -40.0% |
SYRS | Syros Pharmaceuticals, Inc. | $6,101,000 | -17.1% | 690,167 | 0.0% | 0.02% | -25.0% | |
AUTL | Sell | Autolus Therapeutics plcsponsored ads | $5,370,000 | -31.0% | 461,324 | -5.0% | 0.02% | -38.2% |
RETA | Sell | Reata Pharmaceuticals, Inc.cl a | $5,181,000 | -40.7% | 53,183 | -5.0% | 0.02% | -46.2% |
REPL | Buy | Replimune Group, Inc. | $4,756,000 | +3615.6% | 206,586 | +3918.4% | 0.02% | +1800.0% |
CRNX | Sell | Crinetics Pharmaceuticals, Inc. | $4,737,000 | -14.9% | 302,320 | -4.9% | 0.02% | -24.0% |
IFRX | Sell | Inflarx N.V. | $4,292,000 | -11.7% | 1,007,559 | -4.8% | 0.02% | -19.0% |
ITOS | New | Iteos Therapeutics, Inc. | $4,134,000 | – | 167,562 | +100.0% | 0.02% | – |
LEGN | Sell | Legend Biotech Corporationsponsored ads | $3,958,000 | -31.1% | 128,200 | -5.0% | 0.02% | -36.0% |
AKRO | New | Akero Therapeutics, Inc. | $4,058,000 | – | 131,788 | +100.0% | 0.02% | – |
DNLI | Sell | Denali Therapeutics Inc. | $3,562,000 | +40.5% | 99,400 | -5.2% | 0.01% | +27.3% |
PASG | Sell | Passage Bio, Inc. | $3,423,000 | -54.5% | 261,066 | -5.1% | 0.01% | -57.6% |
OVID | Buy | Ovid Therapeutics Inc. | $3,391,000 | +0.4% | 590,761 | +28.9% | 0.01% | -6.7% |
TARA | Protara Therapeutics, Inc. | $3,360,000 | -42.6% | 199,671 | 0.0% | 0.01% | -50.0% | |
CHMA | Sell | Chiasma, Inc. | $3,191,000 | -37.3% | 742,133 | -21.6% | 0.01% | -40.9% |
INZY | New | Inozyme Pharma, Inc. | $3,115,000 | – | 118,500 | +100.0% | 0.01% | – |
XLRN | Sell | Acceleron Pharma Inc. | $2,885,000 | +12.2% | 25,640 | -5.0% | 0.01% | +9.1% |
KZR | Sell | Kezar Life Sciences, Inc. | $2,783,000 | -10.5% | 574,958 | -4.2% | 0.01% | -21.4% |
ALEC | Sell | Alector, Inc. | $2,798,000 | -59.1% | 265,600 | -5.1% | 0.01% | -63.3% |
CNST | Constellation Pharmaceuticals, Inc. | $2,701,000 | -32.6% | 133,333 | 0.0% | 0.01% | -38.9% | |
GMDA | Sell | Gamida Cell Ltd. | $2,628,000 | -13.8% | 633,324 | -5.0% | 0.01% | -15.4% |
TCRR | New | TCR2 Therapeutics Inc. | $2,490,000 | – | 122,532 | +100.0% | 0.01% | – |
NTLA | Sell | Intellia Therapeutics, Inc. | $2,430,000 | -10.1% | 122,238 | -4.9% | 0.01% | -16.7% |
VKTX | Sell | Viking Therapeutics, Inc. | $2,352,000 | -23.2% | 404,200 | -4.9% | 0.01% | -35.7% |
NGM | Sell | NGM Biopharmaceuticals, Inc. | $1,879,000 | -23.5% | 118,100 | -5.1% | 0.01% | -27.3% |
RCUS | Sell | Arcus Biosciences, Inc. | $1,978,000 | -34.2% | 115,425 | -5.0% | 0.01% | -38.5% |
DRNA | Sell | Dicerna Pharmaceuticals, Inc. | $2,035,000 | -32.9% | 113,135 | -5.2% | 0.01% | -38.5% |
GLPG | Sell | Galapagos NVsponsored adr | $1,761,000 | -31.7% | 12,412 | -5.0% | 0.01% | -36.4% |
Bellicum Pharmaceuticals, Inc. | $1,637,000 | -11.6% | 249,123 | 0.0% | 0.01% | -12.5% | ||
OYST | Sell | Oyster Point Pharma, Inc. | $1,440,000 | -30.2% | 68,228 | -4.5% | 0.01% | -33.3% |
MTEM | Sell | Molecular Templates, Inc. | $1,625,000 | -25.5% | 148,817 | -5.9% | 0.01% | -40.0% |
CPRX | Sell | Catalyst Pharmaceuticals, Inc. | $1,409,000 | -39.0% | 474,400 | -5.1% | 0.01% | -40.0% |
ORTX | Sell | Orchard Therapeutics plcads | $1,411,000 | -42.0% | 343,202 | -15.4% | 0.01% | -45.5% |
GTH | New | Genetron Holdings Limitedads | $1,194,000 | – | 100,000 | +100.0% | 0.01% | – |
LPTX | Sell | Leap Therapeutics, Inc. | $1,108,000 | -45.8% | 559,705 | -42.8% | 0.00% | -55.6% |
EVFM | Sell | Evofem Biosciences, Inc. | $1,022,000 | -74.7% | 433,048 | -69.6% | 0.00% | -77.8% |
INFI | Infinity Pharmaceuticals, Inc. | $679,000 | +29.3% | 580,400 | 0.0% | 0.00% | +50.0% | |
ADMS | Sell | Adamas Pharmaceuticals, Inc. | $675,000 | +52.7% | 163,830 | -5.1% | 0.00% | +50.0% |
AFMD | Sell | Affimed N.V. | $643,000 | -30.3% | 189,800 | -5.1% | 0.00% | -25.0% |
GLMD | Sell | Galmed Pharmaceuticals Ltd. | $725,000 | -29.7% | 205,375 | -4.7% | 0.00% | -40.0% |
APLT | Sell | Applied Therapeutics, Inc. | $790,000 | -66.9% | 38,034 | -42.3% | 0.00% | -72.7% |
GNFT | Genfit SAads | $150,000 | -3.8% | 28,396 | 0.0% | 0.00% | 0.0% | |
ARAV | Sell | Aravive, Inc. | $357,000 | -87.4% | 75,854 | -68.9% | 0.00% | -92.3% |
SNSS | Sell | Sunesis Pharmaceuticals, Inc. | $66,000 | -55.1% | 53,066 | -90.5% | 0.00% | -100.0% |
MRKR | Exit | Marker Therapeutics, Inc. | $0 | – | -240,505 | -100.0% | -0.00% | – |
MTNB | Exit | Matinas BioPharma Holdings, Inc. | $0 | – | -2,096,375 | -100.0% | -0.01% | – |
ARYA | Exit | ARYA Sciences Acquisition Corp. | $0 | – | -150,000 | -100.0% | -0.01% | – |
ABEO | Exit | Abeona Therapeutics Inc. | $0 | – | -1,590,686 | -100.0% | -0.02% | – |
AIMT | Exit | Aimmune Therapeutics, Inc. | $0 | – | -673,908 | -100.0% | -0.05% | – |
TCDA | Exit | Tricida, Inc. | $0 | – | -787,582 | -100.0% | -0.10% | – |
PRNB | Exit | Principia Biopharma Inc. | $0 | – | -1,580,873 | -100.0% | -0.42% | – |
SGEN | Exit | Seattle Genetics, Inc. | $0 | – | -47,269,424 | -100.0% | -35.43% | – |
Original filings
The following EDGAR filing(s) were analyzed to create this report:
- View 13F-HR filed 2020-11-16
About Baker Brothers Advisors
Baker Brothers Advisors is a well-known investment management firm that specializes in the healthcare sector. The firm was founded in 2000 by brothers Julian and Felix Baker, who are both highly respected in the industry. Julian Baker is the CEO of the firm, while Felix Baker serves as a managing partner.
Baker Brothers Advisors has a reputation for investing in innovative healthcare companies that have the potential to make a significant impact on the industry. The firm has a long-term investment approach and is known for taking large positions in companies that it believes in. Some of the firm's most successful investments include companies such as Pharmacyclics, which was acquired by AbbVie for $21 billion, and Ariad Pharmaceuticals, which was acquired by Takeda for $5.2 billion.
The firm's investment strategy is led by its Chief Investment Officer, Dr. Robert Duggan, who has a background in both medicine and finance. Dr. Duggan is known for his ability to identify promising healthcare companies and for his willingness to take risks on early-stage companies.
Overall, Baker Brothers Advisors is a highly respected investment management firm that has a proven track record of success in the healthcare sector. While the firm's investment approach may not be suitable for all investors, those who are interested in the healthcare sector may want to consider Baker Brothers Advisors as a potential investment opportunity.
It's important to note that this information is for educational purposes only and has not been fact-checked. As with any investment, it's important to do your own research and consult with a financial advisor before making any investment decisions.
Top long-term holdings
Name | Quarters owned | Latest quarter owned | Max weighting |
---|---|---|---|
Incyte Corporation | 42 | Q3 2023 | 37.6% |
ACADIA Pharmaceuticals Inc. | 42 | Q3 2023 | 10.9% |
Biomarin Pharmaceuticals Inc. | 42 | Q3 2023 | 5.9% |
BioCryst Pharmaceuticals, Inc. | 42 | Q3 2023 | 1.7% |
Cerus Corporation | 42 | Q3 2023 | 0.9% |
Insmed Incorporated | 42 | Q3 2023 | 0.4% |
Mirati Therapeutics, Inc. | 41 | Q3 2023 | 1.8% |
Bluebird Bio Inc. | 41 | Q3 2023 | 0.3% |
Heron Therapeutics, Inc. | 39 | Q3 2023 | 1.5% |
ChemoCentryx, Inc. | 37 | Q3 2022 | 0.6% |
View Baker Brothers Advisors's complete holdings history.
Latest significant ownerships (13-D/G)
Filed | Shares | Percentage | |
---|---|---|---|
Neoleukin Therapeutics, Inc. | August 17, 2023 | 9,469,838 | 20.0% |
Mereo Biopharma Group plc | August 10, 2023 | 14,604,391 | 2.2% |
Verastem, Inc. | August 10, 2023 | ? | ? |
TScan Therapeutics, Inc. | June 02, 2023 | 2,793,938 | 6.5% |
ACADIA PHARMACEUTICALS INC | May 24, 2023 | 43,084,280 | 26.5% |
INCYTE CORP | March 15, 2023 | 36,280,967 | 16.3% |
Seagen Inc. | March 13, 2023 | 46,985,656 | 25.1% |
Talis Biomedical Corp | March 10, 2023 | 37,569,140 | 66.2% |
Aeglea BioTherapeutics, Inc. | February 14, 2023 | 6,384,013 | 9.9% |
Merus N.V. | February 14, 2023 | ? | ? |
View Baker Brothers Advisors's complete significant-ownership history.
Latest filings
Type | Filed |
---|---|
3 | 2024-04-18 |
SC 13D | 2024-04-18 |
3 | 2024-04-01 |
4 | 2024-04-01 |
4 | 2024-04-01 |
4 | 2024-04-01 |
SC 13D | 2024-04-01 |
4 | 2024-03-28 |
SC 13D/A | 2024-03-28 |
4 | 2024-03-25 |
View Baker Brothers Advisors's complete filings history.
All filings
- Holdings (13F-HR)
- Significant ownership (13-D/G)
- Insider transactions (4, 5, 6)
- Events (8-K)
- Shareholder votes (proxy)
View complete filings history.