Orbimed Advisors - Q3 2020 holdings

$7.96 Billion is the total value of Orbimed Advisors's 143 reported holdings in Q3 2020. The portfolio turnover from Q2 2020 to Q3 2020 was 38.5% .

 Value Shares↓ Weighting
PRLD NewPRELUDE THERAPEUTICS INC$469,874,00015,594,877
+100.0%
5.91%
SWTX  SPRINGWORKS THERAPEUTICS INC$353,059,000
+13.5%
7,406,3070.0%4.44%
+1.3%
PMVP NewPMV PHARMACEUTICALS INC$260,230,0007,330,423
+100.0%
3.27%
ALXN BuyALEXION PHARMACEUTICALS INC$249,972,000
+3.3%
2,184,500
+1.3%
3.14%
-7.8%
TPTX  TURNING POINT THERAPEUTICS I$239,832,000
+35.3%
2,745,3270.0%3.01%
+20.8%
HZNP BuyHORIZON THERAPEUTICS PUB L$233,720,000
+46.6%
3,008,755
+4.9%
2.94%
+30.9%
IOVA  IOVANCE BIOTHERAPEUTICS INC$218,757,000
+19.9%
6,645,1000.0%2.75%
+7.1%
MRTX SellMIRATI THERAPEUTICS INC$218,688,000
+44.7%
1,317,000
-0.5%
2.75%
+29.2%
MRK  MERCK & CO. INC$214,766,000
+7.3%
2,589,1000.0%2.70%
-4.3%
BMY BuyBRISTOL-MYERS SQUIBB CO$213,975,000
+26.3%
3,549,100
+23.1%
2.69%
+12.7%
BIIB  BIOGEN INC$203,087,000
+6.0%
715,9000.0%2.55%
-5.3%
BSX  BOSTON SCIENTIFIC CORP$185,215,000
+8.8%
4,847,3000.0%2.33%
-2.8%
VRTX  VERTEX PHARMACEUTICALS INC$181,259,000
-6.3%
666,1000.0%2.28%
-16.3%
AFIB NewACUTUS MED INC$163,243,0005,477,958
+100.0%
2.05%
NTRA SellNATERA INC$152,477,000
-5.6%
2,110,700
-34.9%
1.92%
-15.8%
PRVL  PREVAIL THERAPEUTICS INC$140,713,000
-31.7%
13,822,4630.0%1.77%
-39.0%
ARQT  ARCUTIS BIOTHERAPEUTICS INC$136,944,000
-3.1%
4,673,8500.0%1.72%
-13.5%
NBIX BuyNEUROCRINE BIOSCIENCES INC$125,173,000
-13.5%
1,301,715
+9.8%
1.57%
-22.8%
BNR BuyBURNING ROCK BIOTECH LTDsponsored ads$119,032,000
-7.1%
4,746,075
+0.0%
1.50%
-17.1%
HUM  HUMANA INC$116,013,000
+6.7%
280,3000.0%1.46%
-4.7%
ASND SellASCENDIS PHARMA A/Ssponsored adr$113,348,000
-51.0%
734,500
-53.0%
1.42%
-56.2%
RPTX  REPARE THERAPEUTICS INC$105,428,000
-0.8%
3,426,3250.0%1.32%
-11.4%
ETNB Sell89BIO INC$95,697,000
+19.9%
3,729,442
-6.9%
1.20%
+7.0%
DXCM  DEXCOM INC$93,329,000
+1.7%
226,4000.0%1.17%
-9.2%
TBPH BuyTHERAVANCE BIOPHARMA INC$91,950,000
+71.5%
6,219,110
+143.5%
1.16%
+53.1%
PASG  PASSAGE BIO INC$91,284,000
-52.0%
6,962,8990.0%1.15%
-57.2%
TCDA  TRICIDA INC$87,105,000
-67.0%
9,614,2800.0%1.10%
-70.6%
ISRG  INTUITIVE SURGICAL INC$80,036,000
+24.5%
112,8000.0%1.01%
+11.2%
ACET NewADICET BIO INC$79,764,0006,708,507
+100.0%
1.00%
CNC  CENTENE CORP DEL$77,911,000
-8.2%
1,335,7000.0%0.98%
-18.1%
AGIO BuyAGIOS PHARMACEUTICALS INC$77,256,000
-16.4%
2,207,321
+27.7%
0.97%
-25.4%
SRPT SellSAREPTA THERAPEUTICS INC$75,699,000
-15.6%
539,049
-3.7%
0.95%
-24.7%
ORIC  ORIC PHARMACEUTICALS INC$73,078,000
-25.9%
2,921,9670.0%0.92%
-33.8%
AUPH BuyAURINIA PHARMACEUTICALS INC$70,026,000
+260.2%
4,754,000
+297.4%
0.88%
+221.2%
XLRN BuyACCELERON PHARMA INC$67,638,000
+456.8%
601,066
+371.4%
0.85%
+397.1%
KROS  KEROS THERAPEUTICS INC$64,775,000
+2.8%
1,679,4170.0%0.81%
-8.2%
EXEL  EXELIXIS INC$58,780,000
+3.0%
2,404,1000.0%0.74%
-8.1%
LOGC  LOGICBIO THERAPEUTICS INC$58,718,000
+7.3%
6,466,7830.0%0.74%
-4.2%
DCPH  DECIPHERA PHARMACEUTICALS IN$57,748,000
-14.1%
1,125,7000.0%0.73%
-23.3%
GRAY NewGRAYBUG VISION INC$56,888,0004,475,847
+100.0%
0.72%
EW BuyEDWARDS LIFESCIENCES CORP$56,393,000
+53.8%
706,500
+33.2%
0.71%
+37.4%
IMRA  IMARA INC$55,323,000
-26.4%
2,719,9020.0%0.70%
-34.3%
NVUS  NOVUS THERAPEUTICS INC$54,435,000
+3631.0%
3,183,3140.0%0.68%
+3157.1%
NSTG SellNANOSTRING TECHNOLOGIES INC$52,885,000
+51.1%
1,183,100
-0.8%
0.66%
+34.9%
CRSP SellCRISPR THERAPEUTICS AGnamen akt$52,694,000
+2.8%
630,004
-9.7%
0.66%
-8.3%
EHTH  EHEALTH INC$50,446,000
-19.6%
638,5580.0%0.63%
-28.2%
TELA  TELA BIO INC$50,076,000
+27.6%
3,027,5420.0%0.63%
+13.9%
PGNY BuyPROGYNY INC$49,310,000
+460.3%
1,675,500
+391.3%
0.62%
+400.0%
MGTX  MEIRAGTX HLDGS PLC$49,171,000
+5.8%
3,713,8200.0%0.62%
-5.6%
ATRC  ATRICURE INC$49,005,000
-11.2%
1,228,1890.0%0.62%
-20.7%
SYK NewSTRYKER CORPORATION$48,967,000235,000
+100.0%
0.62%
TMO  THERMO FISHER SCIENTIFIC INC$48,700,000
+21.9%
110,3000.0%0.61%
+8.7%
ATNX SellATHENEX INC$48,133,000
-12.8%
3,977,950
-0.8%
0.60%
-22.1%
ADVM BuyADVERUM BIOTECHNOLOGIES INC$47,219,000
-31.3%
4,584,344
+39.3%
0.59%
-38.7%
CHNG NewCHANGE HEALTHCARE INC$44,890,0003,093,700
+100.0%
0.56%
CRNX  CRINETICS PHARMACEUTICALS IN$43,148,000
-10.6%
2,753,5670.0%0.54%
-20.2%
KALA BuyKALA PHARMACEUTICALS INC$40,988,000
-27.8%
5,465,030
+1.2%
0.52%
-35.5%
ABBV  ABBVIE INC$40,642,000
-10.8%
464,0000.0%0.51%
-20.3%
FUSN  FUSION PHARMACEUTICALS INC$38,762,000
-31.2%
3,224,7700.0%0.49%
-38.6%
SCPH  SCPHARMACEUTICALS INC$35,739,000
+1.2%
4,797,1480.0%0.45%
-9.7%
QURE  UNIQURE NV$35,691,000
-18.3%
969,0790.0%0.45%
-27.0%
VRNA BuyVERONA PHARMA PLCsponsored ads$35,536,000
+507.2%
5,694,841
+355.4%
0.45%
+445.1%
PRTA  PROTHENA CORP PLC$35,409,000
-4.5%
3,544,4750.0%0.44%
-14.8%
ACHC SellACADIA HEALTHCARE COMPANY IN$32,854,000
-5.2%
1,114,466
-19.3%
0.41%
-15.4%
SIBN SellSI BONE INC$32,461,000
+47.4%
1,368,500
-0.9%
0.41%
+31.6%
ALPN  ALPINE IMMUNE SCIENCES INC$32,268,000
-9.5%
3,670,9550.0%0.41%
-19.1%
APLT BuyAPPLIED THERAPEUTICS INC$32,109,000
-27.1%
1,546,687
+27.0%
0.40%
-34.8%
PCVX SellVAXCYTE INC$31,641,000
+17.8%
640,760
-24.6%
0.40%
+5.3%
HARP  HARPOON THERAPEUTICS INC$31,189,000
+2.3%
1,835,7040.0%0.39%
-8.6%
ALEC SellALECTOR INC$28,711,000
-80.3%
2,725,313
-54.4%
0.36%
-82.4%
AGLE  AEGLEA BIOTHERAPEUTICS INC$28,470,000
-23.4%
4,015,5240.0%0.36%
-31.5%
IMAB NewI MABsponsored ads$28,503,000606,070
+100.0%
0.36%
XENE  XENON PHARMACEUTICALS INC$27,652,000
-11.7%
2,497,9170.0%0.35%
-21.1%
PFE NewPFIZER INCcall$27,525,000750,000
+100.0%
0.35%
SVA  SINOVAC BIOTECH LTD$27,300,000
+7.1%
2,839,5000.0%0.34%
-4.5%
CRVS  CORVUS PHARMACEUTICALS INC$27,138,000
+47.4%
6,767,5840.0%0.34%
+31.7%
ARCT BuyARCTURUS THERAPEUTICS HLDGS$26,537,000
+137.4%
618,586
+158.6%
0.33%
+112.7%
FLDM BuyFLUIDIGM CORP DEL$26,404,000
+126.5%
3,553,703
+22.2%
0.33%
+102.4%
MRSN SellMERSANA THERAPEUTICS INC$24,743,000
-44.6%
1,328,852
-30.4%
0.31%
-50.6%
NXTC  NEXTCURE INC$23,857,000
-59.0%
2,711,0130.0%0.30%
-63.3%
AMGN  AMGEN INC$23,256,000
+7.8%
91,5000.0%0.29%
-3.9%
NVO  NOVO-NORDISK A Sadr$22,912,000
+6.0%
330,0000.0%0.29%
-5.3%
NMTR  9 METERS BIOPHARMA INC$20,489,000
+40.4%
25,716,7550.0%0.26%
+25.9%
CTIC  CTI BIOPHARMA CORP$20,469,000
+85.3%
9,520,6000.0%0.26%
+65.8%
ALC  ALCON AG$19,945,000
-1.1%
351,3800.0%0.25%
-11.6%
ISEE BuyIVERIC BIO INC$19,243,000
+16.1%
3,411,806
+5.0%
0.24%
+3.9%
OSH NewOAK STR HEALTH INC$17,870,000334,400
+100.0%
0.22%
BuyTRILLIUM THERAPEUTICS INC$17,799,000
+81.7%
1,252,600
+3.4%
0.22%
+62.3%
HRTX BuyHERON THERAPEUTICS INC$17,663,000
+81.8%
1,191,846
+80.5%
0.22%
+62.0%
FLXN  FLEXION THERAPEUTICS INC$17,530,000
-20.8%
1,684,0000.0%0.22%
-29.5%
TEVA  TEVA PHARMACEUTICAL INDS LTDsponsored ads$17,436,000
-26.9%
1,935,2000.0%0.22%
-34.8%
GH NewGUARDANT HEALTH INC$17,248,000154,300
+100.0%
0.22%
PAND NewPANDION THERAPEUTICS INC$16,972,0001,480,940
+100.0%
0.21%
FBRX SellFORTE BIOSCIENCES INC$16,517,000
+19.2%
340,480
-64.2%
0.21%
+6.7%
SNDX  SYNDAX PHARMACEUTICALS INC$16,149,000
-0.4%
1,094,1000.0%0.20%
-11.0%
ZYME SellZYMEWORKS INC$15,889,000
-24.4%
341,102
-41.4%
0.20%
-32.4%
SRRA  SIERRA ONCOLOGY INC$15,763,000
-11.8%
1,477,3200.0%0.20%
-21.4%
RLAY NewRELAY THERAPEUTICS INC$14,907,000350,000
+100.0%
0.19%
PHGE  BIOMX INC$14,668,000
+14.9%
2,313,4890.0%0.18%
+2.2%
ALXN BuyALEXION PHARMACEUTICALS INCcall$14,304,000
+27.4%
125,000
+25.0%
0.18%
+13.9%
LRMR SellLARIMAR THERAPEUTICS INC$13,449,000
+12.1%
886,560
-5.1%
0.17%0.0%
OTIC NewOTONOMY INC$13,163,0003,250,000
+100.0%
0.16%
CMPS NewCOMPASS PATHWAYS PLCsponsored ads$12,215,000350,000
+100.0%
0.15%
GILD  GILEAD SCIENCES INC$12,145,000
-17.9%
192,2000.0%0.15%
-26.4%
BLU  BELLUS HEALTH INC NEW$11,728,000
-77.9%
5,137,2160.0%0.15%
-80.3%
VRCA  VERRICA PHARMACEUTICALS INC$11,453,000
-29.7%
1,479,7330.0%0.14%
-37.1%
ANNX NewANNEXON INC$11,486,000379,947
+100.0%
0.14%
ALBO NewALBIREO PHARMA INC$10,958,000328,385
+100.0%
0.14%
INZY NewINOZYME PHARMA INC$10,527,000400,400
+100.0%
0.13%
NRIX NewNURIX THERAPEUTICS INC$10,473,000300,000
+100.0%
0.13%
AVRO  AVROBIO INC$10,334,000
-25.4%
793,7120.0%0.13%
-33.3%
CLDX  CELLDEX THERAPEUTICS INC NEW$9,269,000
+14.1%
625,0000.0%0.12%
+2.6%
EPIX SellESSA PHARMA INC$8,125,000
-11.0%
1,177,483
-20.0%
0.10%
-20.3%
ARPO  AERPIO PHARMACEUTICALS INC$7,791,000
+20.0%
5,193,9460.0%0.10%
+7.7%
XTNT  XTANT MED HLDGS INC$7,618,000
-8.5%
9,248,6780.0%0.10%
-17.9%
TARA NewPROTARA THERAPEUTICS INC$7,574,000450,000
+100.0%
0.10%
SBBP NewSTRONGBRIDGE BIOPHARMA PLC$7,328,0003,489,369
+100.0%
0.09%
XFOR  X4 PHARMACEUTICALS INC$7,356,000
-27.4%
1,086,4930.0%0.09%
-35.7%
AKUS  AKOUOS INC$7,204,000
+1.6%
315,0000.0%0.09%
-9.0%
DYN NewDYNE THERAPEUTICS INC$7,067,000350,000
+100.0%
0.09%
HCAT  HEALTH CATALYST INC$6,573,000
+25.5%
179,5980.0%0.08%
+12.2%
OM NewOUTSET MED INC$6,250,000125,000
+100.0%
0.08%
RCKT SellROCKET PHARMACEUTICALS INC$5,786,000
-27.7%
253,108
-33.8%
0.07%
-35.4%
HSAQ NewHEALTH SCIENCES ACQ CORP 2$5,500,000500,000
+100.0%
0.07%
SellAPTOSE BIOSCIENCES INC$5,385,000
-10.2%
897,541
-5.6%
0.07%
-19.0%
SELB  SELECTA BIOSCIENCES INC$5,193,000
-12.7%
2,093,8690.0%0.06%
-22.6%
MYOV NewMYOVANT SCIENCES LTD$5,121,000364,500
+100.0%
0.06%
ARNA  ARENA PHARMACEUTICALS INC$4,988,000
+18.8%
66,7000.0%0.06%
+6.8%
ACAD NewACADIA PHARMACEUTICALS INC$4,414,000107,000
+100.0%
0.06%
SYBX  SYNLOGIC INC$4,101,000
-0.5%
2,029,9960.0%0.05%
-10.3%
KYMR NewKYMERA THERAPEUTICS INC$3,231,000100,000
+100.0%
0.04%
OBSV SellOBSEVA SA$3,231,000
-78.9%
1,303,000
-50.0%
0.04%
-81.0%
IFRX  INFLARX NV$2,891,000
-7.2%
678,5250.0%0.04%
-18.2%
MIST NewMILESTONE PHARMACEUTICALS IN$2,824,000385,791
+100.0%
0.04%
ANAB SellANAPTYSBIO INC$2,662,000
-68.3%
180,442
-52.0%
0.03%
-72.0%
RNA SellAVIDITY BIOSCIENCES INC$1,798,000
-68.2%
63,860
-68.1%
0.02%
-71.2%
KTOV NewKITOV PHARMA LTDsponsord ads new$1,527,000346,197
+100.0%
0.02%
SellNABRIVA THERAPEUTICS PLC$1,410,000
-55.0%
2,644,600
-43.1%
0.02%
-59.1%
CRIS  CURIS INC$1,453,000
-3.3%
1,241,4940.0%0.02%
-14.3%
BMYRT BuyBRISTOL-MYERS SQUIBB COright 99/99/9999$900,000
-28.2%
400,000
+14.3%
0.01%
-38.9%
MYOV NewMYOVANT SCIENCES LTDcall$703,00050,000
+100.0%
0.01%
CALT SellCALLIDITAS THERAPEUTICS ABsponsered ads$425,000
-91.9%
17,696
-92.1%
0.01%
-93.2%
BLRX  BIOLINERX LTDsponsored ads$114,000
-3.4%
69,2400.0%0.00%
-50.0%
ARVN ExitARVINAS INC$0-29,400
-100.0%
-0.01%
MNLO ExitMENLO THERAPEUTICS INC$0-593,883
-100.0%
-0.01%
NTLA ExitINTELLIA THERAPEUTICS INC$0-137,100
-100.0%
-0.04%
CRBP ExitCORBUS PHARMACEUTICALS HLDGSput$0-350,000
-100.0%
-0.04%
ARWR ExitARROWHEAD PHARMACEUTICALS IN$0-68,100
-100.0%
-0.04%
KTOV ExitKITOV PHARMA LTDsponsored ads$0-3,461,983
-100.0%
-0.05%
AGIO ExitAGIOS PHARMACEUTICALS INCcall$0-100,000
-100.0%
-0.08%
RCUS ExitARCUS BIOSCIENCES INC$0-220,350
-100.0%
-0.08%
IGMS ExitIGM BIOSCIENCES INC$0-80,760
-100.0%
-0.08%
TXG Exit10X GENOMICS INC$0-92,700
-100.0%
-0.12%
IMVT ExitIMMUNOVANT INC$0-354,575
-100.0%
-0.12%
ABBV ExitABBVIE INCcall$0-100,000
-100.0%
-0.14%
TORC ExitRESTORBIO INC$0-4,830,387
-100.0%
-0.15%
GNMK ExitGENMARK DIAGNOSTICS INC$0-732,000
-100.0%
-0.15%
REGN ExitREGENERON PHARMACEUTICALS$0-30,900
-100.0%
-0.27%
BFYT ExitBENEFYTT TECHNOLOGIES INC$0-962,900
-100.0%
-0.28%
IQV ExitIQVIA HLDGS INC$0-175,000
-100.0%
-0.35%
IMMU ExitIMMUNOMEDICS INC$0-757,900
-100.0%
-0.38%
INSP ExitINSPIRE MED SYS INC$0-347,000
-100.0%
-0.42%
SLQT ExitSELECTQUOTE INC$0-1,255,000
-100.0%
-0.45%
GKOS ExitGLAUKOS CORP$0-1,211,000
-100.0%
-0.66%
CI ExitCIGNA CORP NEW$0-439,700
-100.0%
-1.16%
Other managers

Other managers that, in addition to the filing manager(s), that filed the EDGAR filing(s):

Original filings

The following EDGAR filing(s) were analyzed to create this report:

  • View 13F-HR filed 2020-11-16
Signatures

The EDGAR filing(s) were signed by:

About Orbimed Advisors

Orbimed Advisors is a leading healthcare-focused investment firm that manages over $16 billion in assets. The firm was founded in 1998 by Samuel Isaly, who has over 50 years of experience in the healthcare industry. Isaly is widely regarded as a pioneer in the field of healthcare investing and has been recognized for his contributions to the industry by numerous organizations.

Orbimed Advisors has a team of over 100 professionals, including investment professionals, research analysts, and operational experts. The firm has offices in New York, San Francisco, Shanghai, and Mumbai, and invests in companies across the healthcare spectrum, including biotechnology, pharmaceuticals, medical devices, and healthcare services.

The firm's investment philosophy is based on a deep understanding of the healthcare industry and a rigorous approach to due diligence. Orbimed Advisors seeks to identify companies with innovative technologies and strong management teams that have the potential to transform the healthcare landscape.

Orbimed Advisors has a strong track record of success, with numerous successful investments in companies such as Juno Therapeutics, Spark Therapeutics, and Kite Pharma. The firm's leadership team, which includes CEO Sven Borho, COO Jonathan Silverstein, and Chief Investment Officer Carl Gordon, has decades of experience in the healthcare industry and is widely respected for their expertise and insights.

Overall, Orbimed Advisors is a leading healthcare investment firm that has a proven track record of success and a deep understanding of the healthcare industry. Investors looking to gain exposure to the healthcare sector may want to consider Orbimed Advisors as a potential investment opportunity.

It's important to note that this information is for educational purposes only and has not been fact-checked. As with any investment, it's important to do your own research and consult with a financial advisor before making any investment decisions.

Top long-term holdings
NameQuarters ownedLatest quarter ownedMax weighting
BIOGEN INC42Q3 20235.0%
VERTEX PHARMACEUTICALS INC42Q3 20233.7%
THERMO FISHER SCIENTIFIC INC42Q3 20233.2%
SINOVAC BIOTECH LTD41Q3 20237.2%
NEUROCRINE BIOSCIENCES INC41Q3 20232.7%
BOSTON SCIENTIFIC CORP40Q3 20235.6%
BRISTOL-MYERS SQUIBB CO40Q2 20235.2%
AMGEN INC40Q3 20235.5%
INTUITIVE SURGICAL INC40Q3 20233.8%
GILEAD SCIENCES INC39Q3 20235.5%

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Latest significant ownerships (13-D/G)
Orbimed Advisors Q3 2020 significant holdings filed using form 13D/G when ownership exceeds 5% of a company's total stock issue.
FiledShares Percentage
Ikena Oncology, Inc.September 21, 20232,189,1115.2%
Galecto, Inc.September 18, 2023749,5572.8%
PMV Pharmaceuticals, Inc.August 23, 20236,563,07713.5%
Gracell Biotechnologies Inc.August 11, 20237,641,5318.0%
Xtant Medical Holdings, Inc.August 03, 202373,114,59256.7%
Turnstone Biologics Corp.July 24, 20233,099,26513.4%
Prelude Therapeutics IncMay 24, 202315,716,64228.6%
VectivBio Holding AGMay 24, 20235,156,5617.7%
Fusion Pharmaceuticals Inc.May 16, 20232,930,6704.6%
Verona Pharma plcMay 16, 20233,777,7784.8%

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Latest filings
TypeFiled
42024-04-18
42024-04-15
3/A2024-04-12
SC 13D/A2024-04-12
42024-04-05
SC 13D/A2024-04-04
32024-04-03
SC 13D2024-03-28
32024-03-27
SC 13D/A2024-03-22

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